{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T18:07:11Z","timestamp":1771956431415,"version":"3.50.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100019346","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21CA280224"],"award-info":[{"award-number":["R21CA280224"]}],"id":[{"id":"10.13039\/100019346","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mucosal-associated invariant T (MAIT) cells are part of a T cell subset ie activated upon presentation of B2 vitamin (riboflavin) metabolites by the major histocompatibility complex, class I related (MR1) protein. Though there is a clear relationship between microbial production of riboflavin and MAIT cell development and persistence, little is known about the cells that primarily communicate with MAIT cells and other MR1-restricted T cells. Elegant work by Deng et al. demonstrates that it is macrophages from the lung and peritoneum that express the highest amount of MR1 and are the most efficient at presenting vitamin B antigens to MAIT cells. This landmark study not only definitively identifies and maps the key antigen presenting cell populations involved in MAIT cell activation but it also reveals a bidirectional relationship between MR1 expression and the host microbiome. While further work on how these findings translate to human MAIT cell biology is needed, this study has provided us with unprecedented insights into the mechanistic interplay and microbial ecology of MR1 presentation of riboflavin metabolites.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag014","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:13:54Z","timestamp":1769422434000},"source":"Crossref","is-referenced-by-count":0,"title":["Tracing MR1 expression across tissues to find the perfect MAIT"],"prefix":"10.1093","volume":"118","author":[{"given":"Christy H","family":"Clutter","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Disease, University of Utah , 30 North Mario Capecchi Dr, Salt Lake City, UT 84112 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8401-0801","authenticated-orcid":false,"given":"Daniel T","family":"Leung","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Disease, University of Utah , 30 North Mario Capecchi Dr, Salt Lake City, UT 84112 ,","place":["United States"]},{"name":"Department of Pathology, Division of Microbiology and Immunology, University of Utah , 15 North Medical Drive East, Ste 1100, Salt Lake City, UT 84112 ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"2026022412255169500_qiag014-B1","doi-asserted-by":"publisher","first-page":"e20231487","DOI":"10.1084\/jem.20231487","article-title":"A conserved transcriptional program for MAIT cells across mammalian evolution","volume":"221","author":"Bugaut","year":"2024","journal-title":"J Exp Med."},{"key":"2026022412255169500_qiag014-B2","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1038\/ni.1890","article-title":"Antimicrobial 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