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They detect diverse ligands in T-cell receptor\u2013dependent or independent manners, producing large quantities of pro-inflammatory cytokines. \u03b3\u03b4 T cells develop in fetal thymi in temporally controlled waves where, unlike \u03b1\u03b2 T cells, many \u03b3\u03b4 T cells adopt their effector fate, becoming either IFN-\u03b3 or IL-17A producers (\u03b3\u03b417 T cells).<\/jats:p>\n                  <jats:p>CD200R1 suppresses myeloid cell activity but has also been shown to promote innate lymphoid cell IL-17A production, enhancing psoriasis-like skin inflammation. \u03b3\u03b417 T cells are potent IL-17A producers in skin. Therefore, the effect of CD200R1 on IL-17A production by \u03b3\u03b417 T cells was investigated using CD200R1KO mice. CD200R1 was revealed to promote IL-17A production by \u03b3\u03b4 T cells in skin and lymphoid organs. Although CD200R1 is not expressed by adult \u03b3\u03b4 T cells, it is expressed by immature developing \u03b3\u03b4 T cells in fetal thymus, where it supports the development of \u03b3\u03b417 T cells, enhancing \u03b3\u03b417 T-cell and ROR\u03b3t+ \u03b3\u03b4 T-cell numbers in fetal thymic organ cultures. This identifies CD200R1 as an important novel regulator of \u03b3\u03b417 T-cell development in early life, a key process for ensuring immunity, particularly at barrier sites.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag015","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T10:13:51Z","timestamp":1769422431000},"source":"Crossref","is-referenced-by-count":0,"title":["CD200R1 promotes the development of murine \u03b3\u03b417 T cells"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4524-6891","authenticated-orcid":false,"given":"Holly","family":"Linley","sequence":"first","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester M13 9PL ,","place":["United 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Centre , Manchester M13 9PL ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6308-7831","authenticated-orcid":false,"given":"Joshua","family":"Cox","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester M13 9PL ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7805-2503","authenticated-orcid":false,"given":"Megan","family":"Priestley","sequence":"additional","affiliation":[{"name":"Lydia Becker Institute of Immunology and Inflammation, Division of Infection, Immunity and Respiratory Medicine, School of Biological Science, Faculty of Biology, Medicine and Health, University of 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Medicine and Health, University of Manchester, Manchester Academic Health Science Centre , Manchester M13 9PL ,","place":["United Kingdom"]},{"name":"Biomedical and Life Sciences, Lancaster University , Bailrigg, Lancaster LA1 4YW ,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"2026022412270281500_qiag015-B1","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.immuni.2009.08.006","article-title":"\u03b3\u03b4 T cells and the lymphoid stress-surveillance response","volume":"31","author":"Hayday","year":"2009","journal-title":"Immunity"},{"key":"2026022412270281500_qiag015-B2","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1038\/nri1030","article-title":"Immunoregulation in the tissues by \u03b3\u03b4 T cells","volume":"3","author":"Hayday","year":"2003","journal-title":"Nat Rev 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