{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T10:37:50Z","timestamp":1781260670780,"version":"3.54.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM124911"],"award-info":[{"award-number":["GM124911"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Despite advances in engineered adaptive immune cell therapies, current options for innate immune cell therapies are sparse. In this work, we demonstrate the utility of a neutrophil progenitor (NP)\u2013based cell therapy. Murine conditionally immortalized NPs overcome some of the hurdles of alternative cell therapies, such as granulocyte transfusion, by engrafting in the unconditioned host and undergoing substantial expansion in vivo. Here, we demonstrate the therapeutic value of NPs using a murine model of the primary immunodeficiency chronic granulomatous disease (CGD). Those with CGD are highly susceptible to infection with Staphylococcus aureus because of genetic mutations that impair neutrophil antimicrobial function. We find that the prophylactic treatment of CGD mice with transfused NPs rescues them from an otherwise lethal S. aureus pulmonary infection. In investigating the mechanisms behind the improved clearance of S. aureus and survival of CGD mice, our data suggest that the antimicrobial function of host CGD neutrophils is rescued by the presence of donor-derived wild-type neutrophils. We also observe that survival is improved to &amp;gt;50% in the CGD model when mice receive NPs postinfection. This work highlights the application of NPs to improving outcomes to acute bacterial infection in CGD, demonstrating the translational potential of conditionally immortalized myeloid progenitors as a cellular therapy.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag020","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:33:48Z","timestamp":1770122028000},"source":"Crossref","is-referenced-by-count":1,"title":["Neutrophil progenitor cell therapy rescues host defense against\n                    <i>Staphylococcus aureus<\/i>\n                    in murine chronic granulomatous disease"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7344-0766","authenticated-orcid":false,"given":"Kristina D","family":"Hinman","sequence":"first","affiliation":[{"name":"Division of Surgical Research, Department of Surgery, Rhode Island Hospital , 593 Eddy Street, Providence, RI 02903 ,","place":["United States"]},{"name":"Department of Surgery, Warren Alpert Medical School of Brown University , 222 Richmond Street, Providence, RI 02903 ,","place":["United States"]},{"name":"Graduate Program in Pathobiology, Brown University , Box G-B495, Providence, RI 02912 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2048-4914","authenticated-orcid":false,"given":"Jason T","family":"Machan","sequence":"additional","affiliation":[{"name":"Biostatistics Core, Rhode Island Hospital , 593 Eddy Street, Providence, RI 02903 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3100-877X","authenticated-orcid":false,"given":"Craig T","family":"Lefort","sequence":"additional","affiliation":[{"name":"Division of Surgical Research, Department of Surgery, Rhode Island Hospital , 593 Eddy Street, Providence, RI 02903 ,","place":["United States"]},{"name":"Department of Surgery, Warren Alpert Medical School of Brown University , 222 Richmond Street, Providence, RI 02903 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"2026031813365182000_qiag020-B1","doi-asserted-by":"publisher","first-page":"eaat4579","DOI":"10.1126\/sciimmunol.aat4579","article-title":"Neutrophils: new insights and open questions","volume":"3","author":"Ley","year":"2018","journal-title":"Sci Immunol"},{"key":"2026031813365182000_qiag020-B2","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1182\/asheducation-2016.1.43","article-title":"Primary immune deficiencies with defects in neutrophil function","volume":"2016","author":"Dinauer","year":"2016","journal-title":"Hematol Am Soc Hematol Educ Program"},{"key":"2026031813365182000_qiag020-B3","doi-asserted-by":"publisher","first-page":"2543","DOI":"10.1007\/s12325-017-0636-2","article-title":"A review of chronic granulomatous 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