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While the roles of Fc\u03b3RIIa and Fc\u03b3RIIIb have been extensively studied in that context, that of Fc\u03b3RI remains elusive. Recently, aggregated IgGs have been shown to induce rapid Fc\u03b3RI up-regulation and reactive oxygen species (ROS) generation, but the biological relevance of this process is still unclear. In this study, incubation of blood samples from healthy volunteers with heat-aggregated IgGs, used as a model of immune complexes, rapidly up-regulated the surface expression of Fc\u03b3RI, predominantly on neutrophils, as measured by flow cytometry. Stimulation of isolated neutrophils with aggregated IgGs resulted in the production of ROS in an Fc\u03b3RI-dependent fashion, as monitored with a luminol-based chemiluminescence assay. Cytochalasin B potentiated Fc\u03b3RI expression and ROS production. In resting blood, positive correlations between neutrophil Fc\u03b3RI and ROS production were observed, both in healthy volunteers and patients with lupus. This study unveils a potentially central regulatory role for neutrophil Fc\u03b3RI in ROS production, both in healthy individuals and patients with lupus, and identifies neutrophil Fc\u03b3RI as a promising target to modulate oxidative response.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag048","type":"journal-article","created":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T11:43:06Z","timestamp":1775907786000},"source":"Crossref","is-referenced-by-count":1,"title":["Neutrophil Fc\u03b3RI expression as a determinant of oxidative responses in human blood"],"prefix":"10.1093","volume":"118","author":[{"given":"Sandrine","family":"Huot","sequence":"first","affiliation":[{"name":"D\u00e9partement de microbiologie-infectiologie et immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval , 1050 avenue de la M\u00e9decine, local 4889, Qu\u00e9bec, QC , G1V0A6","place":["Canada"]},{"name":"Centre de Recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval , site CHUL, 2705 boulevard Laurier, local T1-01, Qu\u00e9bec, QC , G1V 4G2","place":["Canada"]},{"name":"Facult\u00e9 de M\u00e9decine de l'Universit\u00e9 Laval, Centre de recherche ARThrite , 1050 avenue de la M\u00e9decine, local 4889, Qu\u00e9bec, QC , G1V 0A6","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7278-2596","authenticated-orcid":false,"given":"Paul R","family":"Fortin","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval , site CHUL, 2705 boulevard Laurier, local T1-01, Qu\u00e9bec, QC , G1V 4G2","place":["Canada"]},{"name":"Facult\u00e9 de M\u00e9decine de l'Universit\u00e9 Laval, Centre de recherche ARThrite , 1050 avenue de la M\u00e9decine, local 4889, Qu\u00e9bec, QC , G1V 0A6","place":["Canada"]},{"name":"Division de rhumatologie, D\u00e9partement de m\u00e9decine, CHU de Qu\u00e9bec-Universit\u00e9 Laval , 2705 boulevard Laurier, Qu\u00e9bec, QC , G1V 4G2","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia","family":"Laflamme","sequence":"additional","affiliation":[{"name":"Centre de Recherche du CHU de Qu\u00e9bec-Universit\u00e9 Laval , site CHUL, 2705 boulevard Laurier, local T1-01, Qu\u00e9bec, QC , G1V 4G2","place":["Canada"]},{"name":"Facult\u00e9 de M\u00e9decine de l'Universit\u00e9 Laval, Centre de recherche ARThrite , 1050 avenue de la M\u00e9decine, local 4889, Qu\u00e9bec, QC , G1V 0A6","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2466-5424","authenticated-orcid":false,"given":"Marc","family":"Pouliot","sequence":"additional","affiliation":[{"name":"D\u00e9partement de microbiologie-infectiologie et immunologie, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval , 1050 avenue de la M\u00e9decine, local 4889, Qu\u00e9bec, QC , G1V0A6","place":["Canada"]},{"name":"Centre de Recherche du CHU de 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