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While neutrophils are central to acute respiratory distress syndrome, the metabolic pathways fueling their inflammatory response remain unclear. This study identifies CD177 as a critical regulator of neutrophil glycolysis and NLRP3 inflammasome activation. Bioinformatics and animal models show that elevated CD177 correlates strongly with increased lactate and interleukin-1\u03b2 levels. In vitro experiments demonstrate that CD177 knockdown reduces glycolytic flux and suppresses interleukin-1\u03b2 release, a process reversed by lactate supplementation. Furthermore, treating acute respiratory distress syndrome mice with anti-CD177 antibodies significantly reduces pulmonary edema and tissue injury. These results establish the CD177-glycolysis-NLRP3 axis as a major driver of lung inflammation. Targeting this metabolic checkpoint provides a promising strategy for treating acute respiratory distress syndrome.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag051","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:21:31Z","timestamp":1776684091000},"source":"Crossref","is-referenced-by-count":0,"title":["CD177 promotes NLR inflammasome activation in acute respiratory distress syndrome by remodeling neutrophil glycolytic metabolism"],"prefix":"10.1093","volume":"118","author":[{"given":"Dongfeng","family":"Shen","sequence":"first","affiliation":[{"name":"The Intensive Care Unit, The Affiliated Hospital of Jiaxing University (The First Hospital of Jiaxing) , Jiaxing, Zhejiang ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuejiao","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Jiaxing University (The First Hospital of 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