{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:46:13Z","timestamp":1782726373724,"version":"3.54.5"},"reference-count":86,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Arizona Biomedical Research Center New Investigator Award","award":["CTR056057"],"award-info":[{"award-number":["CTR056057"]}]},{"name":"University of Arizona Health Sciences Strategic Initiatives"},{"name":"Immune-Microbe Interface in Health and Disease"},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["T32GM139779"],"award-info":[{"award-number":["T32GM139779"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["F31DE032263"],"award-info":[{"award-number":["F31DE032263"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["T32AG058503"],"award-info":[{"award-number":["T32AG058503"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012264","name":"NIH","doi-asserted-by":"publisher","award":["R01DK141491"],"award-info":[{"award-number":["R01DK141491"]}],"id":[{"id":"10.13039\/501100012264","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Arizona Cancer Center Cancer Biology Program Pilot Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic inflammation and oral dysbiosis are common features of oral squamous cell carcinoma (OSCC). The commensal bacterium Streptococcus anginosus is increased in oral diseases, including OSCC. Our previous work revealed that S. anginosus promotes inflammatory responses from macrophage cell lines; however, the molecular mechanism by which S. anginosus interacts with macrophages to instigate this response remains to be investigated. Here, we found S. anginosus activated primary bone marrow\u2013derived macrophages (BMMs), which presented increased NF-\u03baB activation and downstream inflammatory cytokines TNF-\u03b1, IL-6, and IL-1\u03b2 at 24\u2005h after infection. S. anginosus viability, TLR2, TLR4, and MyD88 were dispensable for NF-\u03baB activation, but each promoted the induction of distinct downstream inflammatory mediators, with only MyD88 being necessary for NF-\u03baB activation in response to heat-killed S. anginosus. S. anginosus replicated intracellularly within BMMs without causing cell death and induced expression of inflammasome sensors AIM2, NLRC4, and NLRP3. S. anginosus\u2013infected BMMs lacking the inflammasome adapter protein ASC (Asc\u2212\/\u2212) or caspase-1 (Caspase1\u2212\/\u2212) had significantly diminished IL-1\u03b2 production compared with wild-type (WT) BMMs, indicating that S. anginosus activated the inflammasome. S. anginosus primarily triggered the inflammasome through NLRP3: S. anginosus\u2013infected Nlrp3\u2212\/\u2212 BMMs and NLRP3 inhibitor (MCC950)-treated WT BMMs displayed diminished IL-1\u03b2 production compared with WT controls. Lastly, S. anginosus\u2013infected Asc\u2212\/\u2212, and to a lesser extent Nlrp3\u2212\/\u2212, mice displayed reduced weight loss, reduced inflammatory cytokines, and increased bacterial burden compared with C57BL\/6 mice. These findings indicate S. anginosus replicates within macrophages and promotes a proinflammatory response in part through activating the NLRP3 inflammasome.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag061","type":"journal-article","created":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:38:49Z","timestamp":1778153929000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Streptococcus anginosus<\/i>\n                    activates the NLRP3 inflammasome to promote inflammatory responses from macrophages"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8025-4153","authenticated-orcid":false,"given":"Anika M","family":"Arias","sequence":"first","affiliation":[{"name":"Cancer Biology Graduate Interdisciplinary Program, University of Arizona , Tucson, AZ 85724 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-4329","authenticated-orcid":false,"given":"Dakota M","family":"Reinartz","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona , Tucson, AZ 85724 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Sairs","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona , Tucson, AZ 85724 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1004-0773","authenticated-orcid":false,"given":"Sangeetha Senthil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Immunobiology, University of Arizona , Tucson, AZ 85724 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harrison C","family":"Byrnes","sequence":"additional","affiliation":[{"name":"Department of Molecular & Cellular Biology, University of Arizona , Tucson, AZ 85724 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-3280","authenticated-orcid":false,"given":"Justin E","family":"Wilson","sequence":"additional","affiliation":[{"name":"Cancer Biology Graduate Interdisciplinary Program, University of Arizona , Tucson, AZ 85724 ,","place":["United States"]},{"name":"Department of Immunobiology, University of Arizona , Tucson, AZ 85724 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,8]]},"reference":[{"key":"2026062905114728100_qiag061-B1","doi-asserted-by":"publisher","first-page":"c4684","DOI":"10.1136\/bmj.c4684","article-title":"Head and neck cancer\u2013part 1: epidemiology, presentation, and prevention","volume":"341","author":"Mehanna","year":"2010","journal-title":"BMJ"},{"key":"2026062905114728100_qiag061-B2","doi-asserted-by":"publisher","first-page":"2289","DOI":"10.1016\/S0140-6736(21)01550-6","article-title":"Head and neck cancer","volume":"398","author":"Mody","year":"2021","journal-title":"Lancet"},{"key":"2026062905114728100_qiag061-B3","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1002\/ijc.35278","article-title":"The GLOBOCAN 2022 cancer estimates: data sources, methods, and a snapshot of the cancer burden worldwide","volume":"156","author":"Filho","year":"2024","journal-title":"Int J Cancer"},{"key":"2026062905114728100_qiag061-B4","doi-asserted-by":"publisher","first-page":"51","DOI":"10.3322\/caac.21384","article-title":"The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012","volume":"67","author":"Shield","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"2026062905114728100_qiag061-B5","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.aodf.2007.10.014","article-title":"Tissue biomarkers for diagnosis & management of oral squamous cell carcinoma","volume":"100","author":"D'Silva","year":"2007","journal-title":"Alpha Omegan"},{"key":"2026062905114728100_qiag061-B6","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.jcms.2014.04.022","article-title":"The prevalence of human papilloma virus (HPV) infections in oral squamous cell carcinomas: a retrospective analysis of 88 patients and literature overview","volume":"42","author":"Kruger","year":"2014","journal-title":"J Craniomaxillofac Surg"},{"key":"2026062905114728100_qiag061-B7","doi-asserted-by":"publisher","first-page":"32762","DOI":"10.3402\/jom.v8.32762","article-title":"Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria","volume":"8","author":"Perera","year":"2016","journal-title":"J Oral Microbiol"},{"key":"2026062905114728100_qiag061-B8","doi-asserted-by":"publisher","first-page":"8323","DOI":"10.3390\/ijms23158323","article-title":"Microbiota and oral cancer as a complex and dynamic microenvironment: a narrative review from etiology to prognosis","volume":"23","author":"Pignatelli","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026062905114728100_qiag061-B9","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1080\/19336918.2017.1322253","article-title":"Periodontal pathogens promote epithelial-mesenchymal transition in oral squamous carcinoma cells in vitro","volume":"12","author":"Abdulkareem","year":"2018","journal-title":"Cell Adh Migr"},{"key":"2026062905114728100_qiag061-B10","doi-asserted-by":"publisher","first-page":"22613","DOI":"10.18632\/oncotarget.4209","article-title":"Periodontal pathogens Porphyromonas gingivalis and Fusobacterium nucleatum promote tumor progression in an oral-specific chemical carcinogenesis model","volume":"6","author":"Binder Gallimidi","year":"2015","journal-title":"Oncotarget"},{"key":"2026062905114728100_qiag061-B11","doi-asserted-by":"publisher","first-page":"3980","DOI":"10.1111\/cas.15538","article-title":"The oral bacterium Streptococcus mutans promotes tumor metastasis by inducing vascular inflammation","volume":"113","author":"Yu","year":"2022","journal-title":"Cancer Sci"},{"key":"2026062905114728100_qiag061-B12","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1016\/j.semcancer.2021.11.002","article-title":"The oral microbiota and its role in carcinogenesis","volume":"86","author":"Stasiewicz","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"2026062905114728100_qiag061-B13","doi-asserted-by":"publisher","first-page":"699","DOI":"10.3892\/ijmm.6.6.699","article-title":"Streptococcus anginosus in head and neck squamous cell carcinoma: implication in carcinogenesis","volume":"6","author":"Tateda","year":"2000","journal-title":"Int J Mol Med"},{"key":"2026062905114728100_qiag061-B14","doi-asserted-by":"publisher","first-page":"13720","DOI":"10.1038\/s41598-023-40981-1","article-title":"Streptolysin S induces pronounced calcium-ion influx-dependent expression of immediate early genes encoding transcription factors","volume":"13","author":"Yamada","year":"2023","journal-title":"Sci Rep"},{"key":"2026062905114728100_qiag061-B15","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1186\/s12903-021-01505-3","article-title":"Effect of Streptococcus anginosus on biological response of tongue squamous cell carcinoma cells","volume":"21","author":"Xu","year":"2021","journal-title":"BMC Oral Health"},{"key":"2026062905114728100_qiag061-B16","doi-asserted-by":"publisher","first-page":"882","DOI":"10.1016\/j.cell.2024.01.004","article-title":"Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice","volume":"187","author":"Fu","year":"2024","journal-title":"Cell"},{"key":"2026062905114728100_qiag061-B17","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1146\/annurev-immunol-032414-112240","article-title":"Innate immune pattern recognition: a cell biological perspective","volume":"33","author":"Brubaker","year":"2015","journal-title":"Annu Rev Immunol"},{"key":"2026062905114728100_qiag061-B18","doi-asserted-by":"publisher","first-page":"812774","DOI":"10.3389\/fimmu.2022.812774","article-title":"Toll-like receptor signaling and its role in cell-mediated immunity","volume":"13","author":"Duan","year":"2022","journal-title":"Front Immunol"},{"key":"2026062905114728100_qiag061-B19","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1007\/s00415-022-11491-3","article-title":"Toll-like receptors and NLRP3 inflammasome-dependent pathways in Parkinson's disease: mechanisms and therapeutic implications","volume":"270","author":"Soraci","year":"2023","journal-title":"J Neurol"},{"key":"2026062905114728100_qiag061-B20","doi-asserted-by":"publisher","first-page":"2114","DOI":"10.1038\/s41423-021-00740-6","article-title":"NLRP3 inflammasome activation and cell death","volume":"18","author":"Huang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"2026062905114728100_qiag061-B21","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1002\/eji.201848070","article-title":"Role of AIM2 inflammasome in inflammatory diseases, cancer and infection","volume":"49","author":"Sharma","year":"2019","journal-title":"Eur J Immunol"},{"key":"2026062905114728100_qiag061-B22","doi-asserted-by":"publisher","first-page":"eabj3859","DOI":"10.1126\/sciimmunol.abj3859","article-title":"NLRP3 inflammasome activation triggers gasdermin D-independent inflammation","volume":"6","author":"Wang","year":"2021","journal-title":"Sci Immunol"},{"key":"2026062905114728100_qiag061-B23","doi-asserted-by":"publisher","first-page":"679","DOI":"10.4049\/immunohorizons.2400019","article-title":"Gasdermin D and gasdermin E are dispensable for silica-mediated IL-1\u03b2 secretion from mouse macrophages","volume":"8","author":"Leung","year":"2024","journal-title":"Immunohorizons"},{"key":"2026062905114728100_qiag061-B24","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1016\/j.celrep.2014.06.028","article-title":"The neutrophil NLRC4 inflammasome selectively promotes IL-1\u03b2 maturation without pyroptosis during acute Salmonella challenge","volume":"8","author":"Chen","year":"2014","journal-title":"Cell Rep"},{"key":"2026062905114728100_qiag061-B25","doi-asserted-by":"publisher","first-page":"1412","DOI":"10.1016\/j.immuni.2019.04.005","article-title":"Cell survival and cytokine release after inflammasome activation is regulated by the Toll-IL-1R protein SARM","volume":"50","author":"Carty","year":"2019","journal-title":"Immunity"},{"key":"2026062905114728100_qiag061-B26","doi-asserted-by":"publisher","first-page":"214","DOI":"10.22038\/IJBMS.2023.72584.15791","article-title":"Role of cell surface proteins and Toll-like receptors in the pathogenesis of Streptococcus pneumoniae","volume":"27","author":"Zaipul Anuar","year":"2024","journal-title":"Iran J Basic Med Sci"},{"key":"2026062905114728100_qiag061-B27","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1111\/imcb.12523","article-title":"Pilus proteins from Streptococcus pyogenes stimulate innate immune responses through Toll-like receptor 2","volume":"100","author":"Takahashi","year":"2022","journal-title":"Immunol Cell Biol"},{"key":"2026062905114728100_qiag061-B28","doi-asserted-by":"publisher","first-page":"614801","DOI":"10.3389\/fimmu.2020.614801","article-title":"The role of NLRP3 inflammasome in pneumococcal infections","volume":"11","author":"Surabhi","year":"2020","journal-title":"Front Immunol"},{"key":"2026062905114728100_qiag061-B29","doi-asserted-by":"publisher","first-page":"3876","DOI":"10.3390\/ijms22083876","article-title":"The critical role of NLRP6 inflammasome in Streptococcus pneumoniae infection in vitro and in vivo","volume":"22","author":"Xu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026062905114728100_qiag061-B30","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1093\/jleuko\/qiad089","article-title":"Inflammatory macrophages exploited by oral Streptococcus increase IL-1B release via NLRP6 inflammasome","volume":"114","author":"Metcalfe","year":"2023","journal-title":"J Leukoc Biol"},{"key":"2026062905114728100_qiag061-B31","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1016\/j.cell.2018.09.047","article-title":"The NLRP6 inflammasome recognizes lipoteichoic acid and regulates gram-positive pathogen infection","volume":"175","author":"Hara","year":"2018","journal-title":"Cell"},{"key":"2026062905114728100_qiag061-B32","doi-asserted-by":"publisher","first-page":"4890","DOI":"10.4049\/jimmunol.1100381","article-title":"Critical roles of ASC inflammasomes in caspase-1 activation and host innate resistance to Streptococcus pneumoniae infection","volume":"187","author":"Fang","year":"2011","journal-title":"J Immunol"},{"key":"2026062905114728100_qiag061-B33","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1084\/jem.20150237","article-title":"NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes","volume":"214","author":"Freeman","year":"2017","journal-title":"J Exp Med"},{"key":"2026062905114728100_qiag061-B34","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.1084\/jem.20100257","article-title":"Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella","volume":"207","author":"Broz","year":"2010","journal-title":"J Exp Med"},{"key":"2026062905114728100_qiag061-B35","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1038\/s41385-018-0088-2","article-title":"NLRC4 suppresses IL-17A-mediated neutrophil-dependent host defense through upregulation of IL-18 and induction of necroptosis during gram-positive pneumonia","volume":"12","author":"Paudel","year":"2019","journal-title":"Mucosal Immunol"},{"key":"2026062905114728100_qiag061-B36","doi-asserted-by":"publisher","first-page":"e0053623","DOI":"10.1128\/iai.00536-23","article-title":"Oral streptococci S. anginosus and S. mitis induce distinct morphological, inflammatory, and metabolic signatures in macrophages","volume":"92","author":"Senthil Kumar","year":"2024","journal-title":"Infect Immun"},{"key":"2026062905114728100_qiag061-B37","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.mimet.2015.06.010","article-title":"Codon-optimized fluorescent mTFP and mCherry for microscopic visualization and genetic counterselection of streptococci and enterococci","volume":"116","author":"Vickerman","year":"2015","journal-title":"J Microbiol Methods"},{"key":"2026062905114728100_qiag061-B38","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and IPAF","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"2026062905114728100_qiag061-B39","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1038\/nm.3908","article-title":"Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt","volume":"21","author":"Wilson","year":"2015","journal-title":"Nat Med"},{"key":"2026062905114728100_qiag061-B40","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/978-1-4939-3566-6_13","volume-title":"NLR Proteins: Methods and Protocols","author":"Guey","year":"2016"},{"key":"2026062905114728100_qiag061-B41","doi-asserted-by":"publisher","first-page":"97","DOI":"10.12703\/P6-97","article-title":"Myd88: a central player in innate immune signaling","volume":"6","author":"Deguine","year":"2014","journal-title":"F1000Prime Rep"},{"key":"2026062905114728100_qiag061-B42","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.3390\/ijms19082155","article-title":"Interleukin-1 \u03b2\u2013a friend or foe in malignancies?","volume":"19","author":"Bent","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2026062905114728100_qiag061-B43","doi-asserted-by":"publisher","first-page":"1075834","DOI":"10.3389\/fimmu.2023.1075834","article-title":"Inflammasome activation by gram-positive bacteria: mechanisms of activation and regulation","volume":"14","author":"Keestra-Gounder","year":"2023","journal-title":"Front Immunol"},{"key":"2026062905114728100_qiag061-B44","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/s41568-019-0123-y","article-title":"Diverging inflammasome signals in tumorigenesis and potential targeting","volume":"19","author":"Karki","year":"2019","journal-title":"Nat Rev Cancer"},{"key":"2026062905114728100_qiag061-B45","doi-asserted-by":"publisher","first-page":"5823","DOI":"10.4049\/jimmunol.0900444","article-title":"Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-\u03baB activation but proceeds independently of TLR signaling and P2X7 receptor","volume":"183","author":"Harder","year":"2009","journal-title":"J Immunol"},{"key":"2026062905114728100_qiag061-B46","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1111\/j.1601-0825.2005.01051.x","article-title":"Streptococcus anginosus infection in oral cancer and its infection route","volume":"11","author":"Sasaki","year":"2005","journal-title":"Oral Dis"},{"key":"2026062905114728100_qiag061-B47","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00203-020-02011-w","article-title":"Dysbiosis of salivary microbiome and cytokines influence oral squamous cell carcinoma through inflammation","volume":"203","author":"Rai","year":"2021","journal-title":"Arch Microbiol"},{"key":"2026062905114728100_qiag061-B48","doi-asserted-by":"publisher","first-page":"3132","DOI":"10.4049\/jimmunol.172.5.3132","article-title":"Toll-like receptor 2 plays a role in the early inflammatory response to murine pneumococcal pneumonia but does not contribute to antibacterial defense","volume":"172","author":"Knapp","year":"2004","journal-title":"J Immunol"},{"key":"2026062905114728100_qiag061-B49","doi-asserted-by":"publisher","first-page":"1966","DOI":"10.1073\/pnas.0435928100","article-title":"Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection","volume":"100","author":"Malley","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026062905114728100_qiag061-B50","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.cellimm.2007.04.003","article-title":"TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae","volume":"245","author":"Lee","year":"2007","journal-title":"Cell Immunol"},{"key":"2026062905114728100_qiag061-B51","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1016\/j.immuni.2024.03.005","article-title":"Myeloid C-type lectin receptors in innate immune recognition","volume":"57","author":"Reis e Sousa","year":"2024","journal-title":"Immunity"},{"key":"2026062905114728100_qiag061-B52","doi-asserted-by":"publisher","first-page":"E10662","DOI":"10.1073\/pnas.1809100115","article-title":"Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection","volume":"115","author":"Imai","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026062905114728100_qiag061-B53","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1073\/pnas.0307124101","article-title":"The C-type lectin SIGN-R1 mediates uptake of the capsular polysaccharide of Streptococcus pneumoniae in the marginal zone of mouse spleen","volume":"101","author":"Kang","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026062905114728100_qiag061-B54","doi-asserted-by":"publisher","first-page":"564","DOI":"10.3390\/pathogens13070564","article-title":"Annexin A2: a double-edged sword in pathogen infection","volume":"13","author":"Wang","year":"2024","journal-title":"Pathogens"},{"key":"2026062905114728100_qiag061-B55","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1189\/jlb.0307154","article-title":"Annexin A2 is a soluble mediator of macrophage activation","volume":"82","author":"Swisher","year":"2007","journal-title":"J Leukoc Biol"},{"key":"2026062905114728100_qiag061-B56","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1111\/j.1699-0463.1994.tb05218.x","article-title":"Identification of a soluble Fc gamma-binding molecule (annexin II) in human serum using a competitive ELISA","volume":"102","author":"Ulvestad","year":"1994","journal-title":"APMIS"},{"key":"2026062905114728100_qiag061-B57","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1111\/cmi.12527","article-title":"Intracellular replication of Staphylococcus aureus in mature phagolysosomes in macrophages precedes host cell death, and bacterial escape and dissemination","volume":"18","author":"Flannagan","year":"2016","journal-title":"Cell Microbiol"},{"key":"2026062905114728100_qiag061-B58","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/s41467-021-21186-4","article-title":"Salmonella typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence","volume":"12","author":"Jiang","year":"2021","journal-title":"Nat Commun"},{"key":"2026062905114728100_qiag061-B59","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.4049\/jimmunol.1401624","article-title":"Neutrophil IL-1\u03b2 processing induced by pneumolysin is mediated by the NLRP3\/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux","volume":"194","author":"Karmakar","year":"2015","journal-title":"J Immunol"},{"key":"2026062905114728100_qiag061-B60","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.cell.2016.05.076","article-title":"Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan","volume":"166","author":"Wolf","year":"2016","journal-title":"Cell"},{"key":"2026062905114728100_qiag061-B61","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","article-title":"The NLRP3 inflammasome: activation and regulation","volume":"48","author":"Xu","year":"2023","journal-title":"Trends Biochem Sci"},{"key":"2026062905114728100_qiag061-B62","doi-asserted-by":"publisher","first-page":"100869","DOI":"10.1016\/j.mam.2020.100869","article-title":"Immunobiology and structural biology of AIM2 inflammasome","volume":"76","author":"Wang","year":"2020","journal-title":"Mol Aspects Med"},{"key":"2026062905114728100_qiag061-B63","doi-asserted-by":"publisher","first-page":"eabi4493","DOI":"10.1126\/sciimmunol.abi4493","article-title":"DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs","volume":"6","author":"Wang","year":"2021","journal-title":"Sci Immunol"},{"key":"2026062905114728100_qiag061-B64","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.molimm.2023.03.016","article-title":"ALK-JNK signaling promotes NLRP3 inflammasome activation and pyroptosis via NEK7 during Streptococcus pneumoniae infection","volume":"157","author":"Wang","year":"2023","journal-title":"Mol Immunol"},{"key":"2026062905114728100_qiag061-B65","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s13567-024-01376-w","article-title":"RACK1 and NEK7 mediate GSDMD-dependent macrophage pyroptosis upon Streptococcus suis infection","volume":"55","author":"Shen","year":"2024","journal-title":"Vet Res"},{"key":"2026062905114728100_qiag061-B66","doi-asserted-by":"publisher","first-page":"2258057","DOI":"10.1080\/21505594.2023.2258057","article-title":"The pseudokinase MLKL contributes to host defense against Streptococcus pluranimalium infection by mediating NLRP3 inflammasome activation and extracellular trap formation","volume":"14","author":"Lei","year":"2023","journal-title":"Virulence"},{"key":"2026062905114728100_qiag061-B67","doi-asserted-by":"publisher","first-page":"3881","DOI":"10.4049\/jimmunol.1301974","article-title":"Inflammasome priming by lipopolysaccharide is dependent upon ERK signaling and proteasome function","volume":"192","author":"Ghonime","year":"2014","journal-title":"J Immunol"},{"key":"2026062905114728100_qiag061-B68","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41368-018-0024-z","article-title":"Streptococcus mutans activates the AIM2, NLRP3 and NLRC4 inflammasomes in human THP-1 macrophages","volume":"10","author":"Song","year":"2018","journal-title":"Int J Oral Sci"},{"key":"2026062905114728100_qiag061-B69","doi-asserted-by":"publisher","first-page":"6881","DOI":"10.1128\/IAI.69.11.6881-6886.2001","article-title":"Effect of deficiency of tumor necrosis factor alpha or both of its receptors on Streptococcus pneumoniae central nervous system infection and peritonitis","volume":"69","author":"Wellmer","year":"2001","journal-title":"Infect Immun"},{"key":"2026062905114728100_qiag061-B70","doi-asserted-by":"publisher","first-page":"3204","DOI":"10.1128\/IAI.00224-15","article-title":"Sensing of interleukin-1 cytokines during Streptococcus pneumoniae colonization contributes to macrophage recruitment and bacterial clearance","volume":"83","author":"Lemon","year":"2015","journal-title":"Infect Immun"},{"key":"2026062905114728100_qiag061-B71","doi-asserted-by":"publisher","first-page":"3694","DOI":"10.1111\/febs.15715","article-title":"More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization","volume":"288","author":"Kieler","year":"2021","journal-title":"FEBS J"},{"key":"2026062905114728100_qiag061-B72","doi-asserted-by":"publisher","first-page":"4148","DOI":"10.1128\/IAI.00181-07","article-title":"Transcriptome analysis of murine macrophages in response to infection with Streptococcus pyogenes reveals an unusual activation program","volume":"75","author":"Goldmann","year":"2007","journal-title":"Infect Immun"},{"key":"2026062905114728100_qiag061-B73","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1089\/dna.2009.0868","article-title":"Bacterial and host interactions of oral streptococci","volume":"28","author":"Kreth","year":"2009","journal-title":"DNA Cell Biol"},{"key":"2026062905114728100_qiag061-B74","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1128\/MMBR.00024-07","article-title":"Interspecies interactions within oral microbial communities","volume":"71","author":"Kuramitsu","year":"2007","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026062905114728100_qiag061-B75","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/omi.12162","article-title":"Acid-adaptive mechanisms of Streptococcus mutans\u2013the more we know, the more we don't","volume":"32","author":"Baker","year":"2017","journal-title":"Mol Oral Microbiol"},{"key":"2026062905114728100_qiag061-B76","doi-asserted-by":"publisher","first-page":"e0009523","DOI":"10.1128\/mmbr.00095-23","article-title":"Insights into the enigma of oral streptococci in carcinogenesis","volume":"88","author":"Senthil Kumar","year":"2024","journal-title":"Microbiol Mol Biol Rev"},{"key":"2026062905114728100_qiag061-B77","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1111\/j.1349-7006.2004.tb02488.x","article-title":"Frequent and preferential infection of Treponema denticola, Streptococcus mitis, and Streptococcus anginosus in esophageal cancers","volume":"95","author":"Narikiyo","year":"2004","journal-title":"Cancer Sci"},{"key":"2026062905114728100_qiag061-B78","doi-asserted-by":"publisher","first-page":"e53","DOI":"10.1371\/journal.pmed.0030053","article-title":"Viable group A streptococci in macrophages during acute soft tissue infection","volume":"3","author":"Thulin","year":"2006","journal-title":"PLoS Med"},{"key":"2026062905114728100_qiag061-B79","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nri1703","article-title":"NF-\u03baB: linking inflammation and immunity to cancer development and progression","volume":"5","author":"Karin","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"2026062905114728100_qiag061-B80","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1038\/nrc2628","article-title":"Tumour necrosis factor and cancer","volume":"9","author":"Balkwill","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"2026062905114728100_qiag061-B81","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s12943-018-0900-3","article-title":"Role of the NLRP3 inflammasome in cancer","volume":"17","author":"Moossavi","year":"2018","journal-title":"Mol Cancer"},{"key":"2026062905114728100_qiag061-B82","doi-asserted-by":"publisher","first-page":"13657","DOI":"10.3390\/ijms241713657","article-title":"Salivary chemical barrier proteins in oral squamous cell carcinoma-alterations in the defense mechanism of the oral cavity","volume":"24","author":"Kallo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026062905114728100_qiag061-B83","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.3390\/cancers15051510","article-title":"Salivary interleukin levels in oral squamous cell carcinoma and oral epithelial dysplasia: findings from a Sri Lankan study","volume":"15","author":"Piyarathne","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2026062905114728100_qiag061-B84","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.canlet.2014.08.015","article-title":"A novel \u03b2-catenin signaling pathway activated by IL-1\u03b2 leads to the onset of epithelial-mesenchymal transition in breast cancer cells","volume":"354","author":"Perez-Yepez","year":"2014","journal-title":"Cancer Lett"},{"key":"2026062905114728100_qiag061-B85","doi-asserted-by":"publisher","first-page":"563","DOI":"10.3389\/fimmu.2018.00563","article-title":"Immunological approaches towards cancer and inflammation: a cross talk","volume":"9","author":"Qu","year":"2018","journal-title":"Front Immunol"},{"key":"2026062905114728100_qiag061-B86","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1186\/s12885-018-4403-9","article-title":"NLRP3 promotes tumor growth and metastasis in human oral squamous cell carcinoma","volume":"18","author":"Wang","year":"2018","journal-title":"BMC Cancer"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiag061\/68248558\/qiag061.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/6\/qiag061\/68248558\/qiag061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/6\/qiag061\/68248558\/qiag061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:11:53Z","timestamp":1782724313000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/doi\/10.1093\/jleuko\/qiag061\/8672779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,8]]},"references-count":86,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6,8]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiag061","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.03.12.642696","asserted-by":"object"}]},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,5,8]]},"article-number":"qiag061"}}