{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:06:55Z","timestamp":1780301215615,"version":"3.54.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T00:00:00Z","timestamp":1778803200000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Malaria caused by Plasmodium falciparum remains a leading cause of childhood mortality in sub-Saharan Africa. The intraerythrocytic parasite can evade complement-mediated destruction through recruitment of human Factor H (FH). In vitro, Factor H\u2013related protein 1 (FHR-1) competes with FH for binding sites, suggesting a potential role in modulating complement activation during infection. Because one-third of Africans carry a CFHR3\/1 deletion, we examined the impact of FHR-1 deficiency on malaria severity. We analyzed plasma from 500 Ghanaian children presenting with different clinical manifestations. One-third of plasma samples lacked detectable FHR-1 protein, but logistic regression analysis revealed no association between FHR-1 deficiency and risk of severe malaria. In contrast, FHR-1 deficiency was overrepresented among children presenting with anemia and multiple syndromes and affected children exhibited markedly lower hemoglobin levels. These findings indicate that FHR-1 deficiency does not affect overall progression of severe falciparum malaria, but correlates with severe malarial anemia.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag063","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:44:45Z","timestamp":1778672685000},"source":"Crossref","is-referenced-by-count":0,"title":["Factor H\u2013related protein 1 deficiency and risk of severe falciparum malaria in Ghanaian children: a cohort analysis"],"prefix":"10.1093","volume":"118","author":[{"given":"Alliyah Uhmon","family":"Byrd","sequence":"first","affiliation":[{"name":"Division of Cellular and Applied Infection Biology, Institute of Biology 2, RWTH Aachen University , Worringerweg 1, 52074 Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Wahler","sequence":"additional","affiliation":[{"name":"Division of Cellular and Applied Infection Biology, Institute of Biology 2, RWTH Aachen University , Worringerweg 1, 52074 Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Thye","sequence":"additional","affiliation":[{"name":"Infectious Disease Epidemiology Department, Bernhard Nocht Institute for Tropical Medicine , Bernhard-Nocht-Strasse 74, 20359 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timo","family":"Reiss","sequence":"additional","affiliation":[{"name":"Division of Cellular and Applied Infection Biology, Institute of Biology 2, RWTH Aachen University , Worringerweg 1, 52074 Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8397-7308","authenticated-orcid":false,"given":"Anna","family":"Bachmann","sequence":"additional","affiliation":[{"name":"Unit of Computational Infection Biology, Bernhard Nocht Institute for Tropical Medicine , Bernhard-Nocht-Strasse 74, 20359 Hamburg ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2264-5558","authenticated-orcid":false,"given":"Gabriele","family":"Pradel","sequence":"additional","affiliation":[{"name":"Division of Cellular and Applied Infection Biology, Institute of Biology 2, RWTH Aachen University , Worringerweg 1, 52074 Aachen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,14]]},"reference":[{"key":"2026060103470488200_qiag063-B1","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/j.molimm.2013.06.001","article-title":"Complement factor H related proteins (CFHRs)","volume":"56","author":"Skerka","year":"2013","journal-title":"Mol Immunol"},{"key":"2026060103470488200_qiag063-B2","doi-asserted-by":"publisher","first-page":"2823","DOI":"10.1111\/bph.15290","article-title":"Factor H-related protein 1: a complement regulatory protein and 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