{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T14:14:36Z","timestamp":1783433676966,"version":"3.54.6"},"reference-count":57,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Limosilactobacillus reuteri (formerly Lactobacillus reuteri) is a well-studied commensal bacterium known for various health benefits. Our recent findings reveal that the human-derived strain L. reuteri CF48-3A enhances endogenous neonatal immunoglobulin A (IgA) production in mice. In a comparative analysis between the human isolates CF48-3A and PTA-6475, we observed that only CF48-3A induces splenocyte IgA production in vitro, highlighting strain-specific functional diversity within L. reuteri. Further study revealed that the 2 strains modulate B cell IgA production through distinct mechanisms, largely due to differences in surface proteins and activation of Toll-like receptor 2 (TLR2). While CF48-3A promotes IgA+ plasmablast differentiation and proliferation, PTA-6475 fails to promote antibody-secreting cell (ASC) populations and does not induce IgA. This latter phenotype was traced to differences in the cell surface architecture. A derivative of PTA-6475 in which 8 genes encoding cell surface proteins were inactivated (L. reuteri VPL4366) gained the function to promote plasmablast differentiation and IgA induction. Additionally, IgA induction by CF48-3A and L. reuteri VPL4366 appears to occur, at least partially, via TLR2 signaling, and is not associated with B lymphocyte stimulator (BLyS) or TGF-\u03b2 signaling. These in vitro findings emphasize that the strain-specific cell wall architecture plausibly impacts L. reuteri on IgA induction and suggests unique mechanisms by which L. reuteri strains influence B cell differentiation.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag088","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:56:04Z","timestamp":1782302164000},"source":"Crossref","is-referenced-by-count":0,"title":["Differences in the cell wall architecture drive strain-specific IgA induction by\n                    <i>Limosilactobacillus reuteri<\/i>"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5015-8170","authenticated-orcid":false,"given":"Ran","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Biomedical Science and Pathobiology, Virginia-Maryland College of Veterinary Medicine , Virginia Tech, 295 Duck Pond Drive, Blacksburg, VA 24061 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brianna K","family":"Swartwout","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Pathobiology, Virginia-Maryland College of Veterinary Medicine , Virginia Tech, 295 Duck Pond Drive, Blacksburg, VA 24061 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9033-8539","authenticated-orcid":false,"given":"Jee-Hwan","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Food Science, University of Wisconsin-Madison , 1605 Linden Dr, Madison, WI 53706 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahitya Ranjan","family":"Biswas","sequence":"additional","affiliation":[{"name":"School of Neuroscience at the College of Science, Virginia Tech , 210 Drillfield Dr, Blacksburg, VA 24061 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan-Peter","family":"van Pijkeren","sequence":"additional","affiliation":[{"name":"Department of Food Science, University of Wisconsin-Madison , 1605 Linden Dr, Madison, WI 53706 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin M","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Science and Pathobiology, Virginia-Maryland College of Veterinary Medicine , Virginia Tech, 295 Duck Pond Drive, Blacksburg, VA 24061 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"2026070709113324100_qiag088-B1","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3389\/fmicb.2018.00757","article-title":"Role of Lactobacillus reuteri in human health and diseases","volume":"9","author":"Mu","year":"2018","journal-title":"Front Microbiol"},{"key":"2026070709113324100_qiag088-B2","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1038\/ismej.2009.123","article-title":"Diversification of the gut symbiont Lactobacillus reuteri as a result of host-driven evolution","volume":"4","author":"Oh","year":"2010","journal-title":"ISME J"},{"key":"2026070709113324100_qiag088-B3","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1007\/s00535-021-01774-3","article-title":"Lactobacillus stress protein GroEL prevents colonic inflammation","volume":"56","author":"Dias","year":"2021","journal-title":"J Gastroenterol."},{"key":"2026070709113324100_qiag088-B4","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1186\/1471-2180-9-35","article-title":"Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors","volume":"9","author":"Jones","year":"2009","journal-title":"BMC Microbiol"},{"key":"2026070709113324100_qiag088-B5","doi-asserted-by":"publisher","first-page":"1228754","DOI":"10.3389\/fimmu.2023.1228754","article-title":"Limosilactobacillus reuteri in immunomodulation: molecular mechanisms and potential applications","volume":"14","author":"Luo","year":"2023","journal-title":"Front Immunol."},{"key":"2026070709113324100_qiag088-B6","doi-asserted-by":"publisher","first-page":"e0299792","DOI":"10.1371\/journal.pone.0299792","article-title":"Anti-inflammatory potential via the MAPK signaling pathway of Lactobacillus spp. Isolated from canine feces","volume":"19","author":"Park","year":"2024","journal-title":"PLoS One"},{"key":"2026070709113324100_qiag088-B7","doi-asserted-by":"publisher","first-page":"e31951","DOI":"10.1371\/journal.pone.0031951","article-title":"Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling","volume":"7","author":"Thomas","year":"2012","journal-title":"PLoS One"},{"key":"2026070709113324100_qiag088-B8","doi-asserted-by":"publisher","first-page":"115321","DOI":"10.1016\/j.celrep.2025.115321","article-title":"A secondary metabolite of Limosilactobacillus reuteri R2lc drives strain-specific pathology in a spontaneous mouse model of multiple sclerosis","volume":"44","author":"Archer","year":"2025","journal-title":"Cell Rep"},{"key":"2026070709113324100_qiag088-B9","doi-asserted-by":"publisher","first-page":"4645","DOI":"10.1073\/pnas.1000099107","article-title":"Host-microbial symbiosis in the vertebrate gastrointestinal tract and the Lactobacillus reuteri paradigm","volume":"108 Suppl 1","author":"Walter","year":"2011","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026070709113324100_qiag088-B10","doi-asserted-by":"publisher","first-page":"e1001314","DOI":"10.1371\/journal.pgen.1001314","article-title":"The evolution of host specialization in the vertebrate gut symbiont Lactobacillus reuteri","volume":"7","author":"Frese","year":"2011","journal-title":"PLoS Genet"},{"key":"2026070709113324100_qiag088-B11","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1038\/ismej.2010.201","article-title":"Structure and functions of exopolysaccharide produced by gut commensal Lactobacillus reuteri 100-23","volume":"5","author":"Sims","year":"2011","journal-title":"ISME J"},{"key":"2026070709113324100_qiag088-B12","doi-asserted-by":"publisher","first-page":"32444","DOI":"10.1074\/jbc.M109.040907","article-title":"Crystal structure of a mucus-binding protein repeat reveals an unexpected functional immunoglobulin binding activity","volume":"284","author":"MacKenzie","year":"2009","journal-title":"J Biol Chem."},{"key":"2026070709113324100_qiag088-B13","doi-asserted-by":"publisher","first-page":"3368","DOI":"10.1099\/mic.0.043265-0","article-title":"Strain-specific diversity of mucus-binding proteins in the adhesion and aggregation properties of Lactobacillus reuteri","volume":"156","author":"MacKenzie","year":"2010","journal-title":"Microbiology (Reading)"},{"key":"2026070709113324100_qiag088-B14","doi-asserted-by":"publisher","first-page":"3074","DOI":"10.1073\/pnas.1315792111","article-title":"Secretory antibodies in breast milk promote long-term intestinal homeostasis by regulating the gut microbiota and host gene expression","volume":"111","author":"Rogier","year":"2014","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026070709113324100_qiag088-B15","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1084\/jem.20052093","article-title":"Innate secretory antibodies protect against natural Salmonella typhimurium infection","volume":"203","author":"Wijburg","year":"2006","journal-title":"J Exp Med."},{"key":"2026070709113324100_qiag088-B16","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/mi.2007.6","article-title":"The immune geography of IgA induction and function","volume":"1","author":"Macpherson","year":"2008","journal-title":"Mucosal Immunol"},{"key":"2026070709113324100_qiag088-B17","doi-asserted-by":"publisher","first-page":"e105370","DOI":"10.1371\/journal.pone.0105370","article-title":"Lactobacillus gasseri SBT2055 induces TGF-beta expression in dendritic cells and activates TLR2 signal to produce IgA in the small intestine","volume":"9","author":"Sakai","year":"2014","journal-title":"PLoS One"},{"key":"2026070709113324100_qiag088-B18","doi-asserted-by":"publisher","first-page":"e25542","DOI":"10.1371\/journal.pone.0025542","article-title":"Toll-like receptor agonists synergize with CD40L to induce either proliferation or plasma cell differentiation of mouse B cells","volume":"6","author":"Boeglin","year":"2011","journal-title":"PLoS One"},{"key":"2026070709113324100_qiag088-B19","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1016\/j.clim.2006.04.571","article-title":"Toll-like receptor 2-mediated human B cell differentiation","volume":"120","author":"Ganley-Leal","year":"2006","journal-title":"Clin. Immunol"},{"key":"2026070709113324100_qiag088-B20","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.clim.2010.09.003","article-title":"Toll-like receptor 2 induces mucosal homing receptor expression and IgA production by human B cells","volume":"138","author":"Liang","year":"2011","journal-title":"Clin. Immunol"},{"key":"2026070709113324100_qiag088-B21","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3389\/fmicb.2013.00073","article-title":"Relevance and application of sortase and sortase-dependent proteins in lactic acid bacteria","volume":"4","author":"Call","year":"2013","journal-title":"Front Microbiol"},{"key":"2026070709113324100_qiag088-B22","doi-asserted-by":"publisher","first-page":"7591","DOI":"10.1021\/bi200844h","article-title":"Staphylococcus aureus sortase A contributes to the Trojan horse mechanism of immune defense evasion with its intrinsic resistance to Cys184 oxidation","volume":"50","author":"Melvin","year":"2011","journal-title":"Biochemistry"},{"key":"2026070709113324100_qiag088-B23","doi-asserted-by":"publisher","first-page":"4143","DOI":"10.1128\/AEM.03023-05","article-title":"Comparative and functional analysis of sortase-dependent proteins in the predicted secretome of Lactobacillus salivarius UCC118","volume":"72","author":"van Pijkeren","year":"2006","journal-title":"Appl Environ Microbiol."},{"key":"2026070709113324100_qiag088-B24","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.3389\/fmicb.2019.02770","article-title":"Role of sortase A in Lactobacillus gasseri Kx110A1 adhesion to gastric epithelial cells and competitive exclusion of Helicobacter pylori","volume":"10","author":"Zuo","year":"2019","journal-title":"Front Microbiol"},{"key":"2026070709113324100_qiag088-B25","doi-asserted-by":"publisher","first-page":"8344","DOI":"10.1128\/AEM.71.12.8344-8351.2005","article-title":"Functional analysis of putative adhesion factors in Lactobacillus acidophilus NCFM","volume":"71","author":"Buck","year":"2005","journal-title":"Appl Environ Microbiol."},{"key":"2026070709113324100_qiag088-B26","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1099\/mic.0.073551-0","article-title":"Role of Lactobacillus reuteri cell and mucus-binding protein A (CmbA) in adhesion to intestinal epithelial cells and mucus in vitro","volume":"160","author":"Jensen","year":"2014","journal-title":"Microbiology (Reading)"},{"key":"2026070709113324100_qiag088-B27","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1128\/JB.01321-12","article-title":"Impact of Lactobacillus plantarum sortase on target protein sorting, gastrointestinal persistence, and host immune response modulation","volume":"195","author":"Remus","year":"2013","journal-title":"J Bacteriol."},{"key":"2026070709113324100_qiag088-B28","doi-asserted-by":"publisher","DOI":"10.3791\/59074","article-title":"Probiotic studies in neonatal mice using gavage","author":"Francis","year":"2019","journal-title":"J Vis Exp"},{"key":"2026070709113324100_qiag088-B29","doi-asserted-by":"publisher","first-page":"e0031224","DOI":"10.1128\/aem.00312-24","article-title":"Development of a Limosilactobacillus reuteri therapeutic delivery platform with reduced colonization potential","volume":"90","author":"Alexander","year":"2024","journal-title":"Appl Environ Microbiol."},{"key":"2026070709113324100_qiag088-B30","doi-asserted-by":"publisher","first-page":"e2015691118","DOI":"10.1073\/pnas.2015691118","article-title":"Regulation of neonatal IgA production by the maternal microbiota","volume":"118","author":"Mu","year":"2021","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026070709113324100_qiag088-B31","volume-title":"Identification and evaluation of Limosilactobacillus reuteri as an inducer of neonatal IgA and autoimmunity","author":"Swartwout","year":"2021"},{"key":"2026070709113324100_qiag088-B32","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.coi.2008.03.014","article-title":"Peripheral B cell subsets","volume":"20","author":"Allman","year":"2008","journal-title":"Curr Opin Immunol."},{"key":"2026070709113324100_qiag088-B33","doi-asserted-by":"publisher","first-page":"839","DOI":"10.4049\/jimmunol.1700461","article-title":"Here, there, and anywhere? Arguments for and against the physical plasma cell survival niche","volume":"199","author":"Wilmore","year":"2017","journal-title":"J. Immunol"},{"key":"2026070709113324100_qiag088-B34","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S1074-7613(00)00044-3","article-title":"TGF-beta receptor controls B cell responsiveness and induction of IgA in vivo","volume":"13","author":"Cazac","year":"2000","journal-title":"Immunity"},{"key":"2026070709113324100_qiag088-B35","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1084\/jem.185.11.1909","article-title":"Human dendritic cells skew isotype switching of CD40-activated naive B cells towards IgA1 and IgA2","volume":"185","author":"Fayette","year":"1997","journal-title":"J Exp Med."},{"key":"2026070709113324100_qiag088-B36","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1084\/jem.170.4.1415","article-title":"Transforming growth factor beta induces IgA production and acts additively with interleukin 5 for IgA production","volume":"170","author":"Sonoda","year":"1989","journal-title":"J Exp Med."},{"key":"2026070709113324100_qiag088-B37","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/ni829","article-title":"DCs induce CD40-independent immunoglobulin class switching through BLyS and APRIL","volume":"3","author":"Litinskiy","year":"2002","journal-title":"Nat Immunol."},{"key":"2026070709113324100_qiag088-B38","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1038\/s41385-019-0192-y","article-title":"The antibody\/microbiota interface in health and disease","volume":"13","author":"Sterlin","year":"2020","journal-title":"Mucosal Immunol"},{"key":"2026070709113324100_qiag088-B39","doi-asserted-by":"publisher","first-page":"3597","DOI":"10.1111\/febs.17089","article-title":"Recent advances in the molecular understanding of immunoglobulin A","volume":"291","author":"Wang","year":"2024","journal-title":"FEBS J"},{"key":"2026070709113324100_qiag088-B40","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/mi.2011.41","article-title":"Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut","volume":"4","author":"Mantis","year":"2011","journal-title":"Mucosal Immunol"},{"key":"2026070709113324100_qiag088-B41","doi-asserted-by":"publisher","first-page":"e0019022","DOI":"10.1128\/aem.00190-22","article-title":"Role of lipoteichoic acid from the genus apilactobacillus in inducing a strong IgA response","volume":"88","author":"Matsuzaki","year":"2022","journal-title":"Appl Environ Microbiol."},{"key":"2026070709113324100_qiag088-B42","doi-asserted-by":"publisher","first-page":"23","DOI":"10.12938\/bmfh.18-015","article-title":"IgA-enhancing effects of membrane vesicles derived from Lactobacillus sakei subsp. sakei NBRC15893","volume":"38","author":"Yamasaki-Yashiki","year":"2019","journal-title":"Biosci Microbiota Food Health"},{"key":"2026070709113324100_qiag088-B43","doi-asserted-by":"publisher","first-page":"3863","DOI":"10.3168\/jds.2020-19437","article-title":"Sex-dependent modulation of immune development in mice by secretory IgA-coated Lactobacillus reuteri isolated from breast milk","volume":"104","author":"Qi","year":"2021","journal-title":"J Dairy Sci."},{"key":"2026070709113324100_qiag088-B44","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1111\/aji.12445","article-title":"Immunomodulation of Lactobacillus reuteri CRL1324 on group B Streptococcus vaginal colonization in a murine experimental model","volume":"75","author":"De Gregorio","year":"2016","journal-title":"Am. J. Reprod. Immunol"},{"key":"2026070709113324100_qiag088-B45","doi-asserted-by":"publisher","first-page":"15587","DOI":"10.1074\/jbc.M212829200","article-title":"Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved","volume":"278","author":"Schroder","year":"2003","journal-title":"J Biol Chem."},{"key":"2026070709113324100_qiag088-B46","doi-asserted-by":"publisher","first-page":"147","DOI":"10.12938\/bmfh.2016-006","article-title":"Structural diversity and biological significance of lipoteichoic acid in gram-positive bacteria: focusing on beneficial probiotic lactic acid bacteria","volume":"35","author":"Shiraishi","year":"2016","journal-title":"Biosci Microbiota Food Health"},{"key":"2026070709113324100_qiag088-B47","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1271\/bbb.110919","article-title":"Enhanced immunomodulatory activity and stability in simulated digestive juices of Lactobacillus plantarum L-137 by heat treatment","volume":"76","author":"Fujiki","year":"2012","journal-title":"Biosci Biotechnol Biochem."},{"key":"2026070709113324100_qiag088-B48","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1111\/j.1348-0421.2009.00189.x","article-title":"Lipoteichoic acids on Lactobacillus plantarum cell surfaces correlate with induction of interleukin-12p40 production","volume":"54","author":"Hirose","year":"2010","journal-title":"Microbiol Immunol."},{"key":"2026070709113324100_qiag088-B49","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/1475-2859-11-161","article-title":"Lipoteichoic acid is an important microbe-associated molecular pattern of Lactobacillus rhamnosus GG","volume":"11","author":"Claes","year":"2012","journal-title":"Microb Cell Fact"},{"key":"2026070709113324100_qiag088-B50","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.intimp.2015.02.011","article-title":"Scavenger receptor for lipoteichoic acid is involved in the potent ability of Lactobacillus plantarum strain L-137 to stimulate production of interleukin-12p40","volume":"25","author":"Hatano","year":"2015","journal-title":"Int Immunopharmacol."},{"key":"2026070709113324100_qiag088-B51","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.4049\/jimmunol.181.3.1767","article-title":"IL-21-induced isotype switching to IgG and IgA by human naive B cells is differentially regulated by IL-4","volume":"181","author":"Avery","year":"2008","journal-title":"J. Immunol"},{"key":"2026070709113324100_qiag088-B52","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.immuni.2008.11.008","article-title":"A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts","volume":"30","author":"Dullaers","year":"2009","journal-title":"Immunity"},{"key":"2026070709113324100_qiag088-B53","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1111\/j.1749-6632.2011.06266.x","article-title":"Regulation of mucosal IgA responses: lessons from primary immunodeficiencies","volume":"1238","author":"Cerutti","year":"2011","journal-title":"Ann N Y Acad Sci."},{"key":"2026070709113324100_qiag088-B54","doi-asserted-by":"publisher","first-page":"1346769","DOI":"10.3389\/fneph.2023.1346769","article-title":"The role of BAFF and APRIL in IgA nephropathy: pathogenic mechanisms and targeted therapies","volume":"3","author":"Cheung","year":"2023","journal-title":"Front Nephrol"},{"key":"2026070709113324100_qiag088-B55","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1159\/000058712","article-title":"T cell and cytokine regulation of the IgA response","volume":"71","author":"Lycke","year":"1998","journal-title":"Chem Immunol."},{"key":"2026070709113324100_qiag088-B56","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1126\/science.1091334","article-title":"Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria","volume":"303","author":"Macpherson","year":"2004","journal-title":"Science"},{"key":"2026070709113324100_qiag088-B57","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1038\/s41586-024-07047-2","article-title":"Bone marrow plasma cells require P2RX4 to sense extracellular ATP","volume":"626","author":"Ishikawa","year":"2024","journal-title":"Nature"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiag088\/68612354\/qiag088.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/7\/qiag088\/68612354\/qiag088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/7\/qiag088\/68612354\/qiag088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:25:18Z","timestamp":1783430718000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/doi\/10.1093\/jleuko\/qiag088\/8716238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,25]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiag088","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,6,25]]},"article-number":"qiag088"}}