{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:31Z","timestamp":1792785991172,"version":"4.5.0"},"reference-count":169,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretaria de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","id":[{"id":"https:\/\/ror.org\/059ex5q34","id-type":"ROR","asserted-by":"crossref"}]},{"name":"PRONACES","award":["302962"],"award-info":[{"award-number":["302962"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Tissue-resident immune cells are specialized populations that survey peripheral tissues independently of circulating input. Their strategic positioning, persistence, and capacity for rapid local response make them key mediators of durable antitumor immunity. Although this biology has been most extensively defined in CD8\u207a tissue-resident memory T (TRM) cells, tissue residency is increasingly recognized as a broader principle of peripheral immunity, extending to CD4\u207a TRM cells, tissue-resident NK cells, and myeloid populations. This review provides an integrative framework tracing tissue-resident biology from its ontogeny to its therapeutic frontier. We propose that TRM differentiation is shaped by the interplay between priming signals and tissue niches, with priming generating residency-poised states that are resolved into stable phenotypes by local tissue cues. We encompass a framework of canonical niches across barrier and nonbarrier tissues, identify shared instructive axes, and extend this classification to noncanonical reservoirs such as bone marrow. We further examine the metabolic dimension of tissue residency: fatty acid oxidation, purinergic adaptation, and hypoxic specialization as an active and instructible program with direct manufacturing implications for cellular immunotherapy. We propose tumors as pathological noncanonical niches in which the mechanisms of tissue retention are preserved but the effector identity is lost, and address how TRM cells nonetheless emerge as critical determinants of immunosurveillance and checkpoint blockade responsiveness. We conclude that integrating tissue-residency principles into next-generation immunotherapy is not a minor refinement but a necessary shift to achieve durable responses in solid tumors.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag102","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T11:28:22Z","timestamp":1784633302000},"source":"Crossref","is-referenced-by-count":0,"title":["From sentinels to soldiers: tissue-resident cells for next-generation immunotherapy"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4519-9582","authenticated-orcid":false,"given":"Nahuel","family":"Ko","sequence":"first","affiliation":[{"name":"Posgrado en Ciencias Biom\u00e9dicas, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Av. Universidad 3000, Circuito Escolar s\/n, Ciudad Universitaria, Coyoac\u00e1n, C.P. 04510 Mexico City ,","place":["Mexico"]},{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social , Av. Cuauht\u00e9moc 330, Col. Doctores, Alcald\u00eda Cuauht\u00e9moc, C.P. 06720 Mexico City ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-9297-0998","authenticated-orcid":false,"given":"Diego","family":"Esperante","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunoqu\u00edmica, Hospital de Especialidades, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social , Av. Cuauht\u00e9moc 330, Col. Doctores, Alcald\u00eda Cuauht\u00e9moc, C.P. 06720 Mexico City ,","place":["M\u00e9xico"]},{"name":"Plan de Estudios Combinados en Medicina (PECEM), Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico (UNAM) , Av. Universidad 3000, Circuito Escolar s\/n, Ciudad Universitaria, Coyoac\u00e1n, C.P. 04510 Mexico City ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0997-1853","authenticated-orcid":false,"given":"F\u00e1tima","family":"Mendoza-Roldan","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunolog\u00eda, Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social , Av. Cuauht\u00e9moc 330, Col. Doctores, Alcald\u00eda Cuauht\u00e9moc, C.P. 06720 Mexico City ,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-6263","authenticated-orcid":false,"given":"Emilia","family":"Schneider-Revueltas","sequence":"additional","affiliation":[{"name":"Cell Biology Lab, German Rheumatology Research Center (DRFZ), a Leibniz-Institute , Charit\u00e9platz 1, 10117 Berlin ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Jimenez-Miranda","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Inmunolog\u00eda, Hospital de Pediatr\u00eda, Centro M\u00e9dico Nacional Siglo XXI, Instituto Mexicano del Seguro Social , Av. Cuauht\u00e9moc 330, Col. 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