{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:13:56Z","timestamp":1792872836529,"version":"4.5.0"},"reference-count":115,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:00Z","timestamp":1785456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1DP2CA280622-01"],"award-info":[{"award-number":["1DP2CA280622-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Emerging evidence has highlighted the influence of cellular metabolism on both cancer and T cell growth and survival, including in the context of adoptive cell immunotherapy. It is known that T cells heavily rely on glycolysis for cell proliferation and mediating effector functions. However, less is known about the role of the pentose phosphate pathway (PPP), a parallel metabolic pathway that produces antioxidant and biosynthetic precursors, toward regulating antitumor T cell function. In this review, we summarize the PPP's role as a time-dependent regulator of T cell activation and redox balance, and its association with improved functional capacity in exhausted T cells. We further highlight the contrasting role of the PPP for CD8+ and CD4+ T cell differentiation in guiding antitumor responses, as well as a unique connection in the glycogen-PPP axis to CD8+ memory T cells. Finally, we summarize global metabolic regulators that drive expression of PPP enzymes and discuss future avenues for immunotherapy that could take advantage of our current understanding of the PPP's role in T cell metabolism.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag106","type":"journal-article","created":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T12:05:13Z","timestamp":1785585913000},"source":"Crossref","is-referenced-by-count":1,"title":["The pentose phosphate pathway in immunotherapy"],"prefix":"10.1093","volume":"118","author":[{"given":"Rachel D","family":"Loo","sequence":"first","affiliation":[{"name":"School of Chemical and Biomolecular Engineering, Georgia Institute of Technology , 311 Ferst Drive NW, Atlanta, GA 30332 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-2938","authenticated-orcid":false,"given":"John","family":"Blazeck","sequence":"additional","affiliation":[{"name":"School of Chemical and Biomolecular Engineering, Georgia Institute of Technology , 311 Ferst Drive NW, Atlanta, GA 30332 ,","place":["United States"]},{"name":"Parker H. Petit Institute of Bioengineering and Bioscience, Georgia Institute of Technology , 315 Ferst Drive NW, Atlanta, GA 30332 ,","place":["United States"]},{"name":"Cancer Technology Innovation Center, Georgia Institute of Technology , 225 North Avenue NW, Atlanta, GA 30332 ,","place":["United States"]},{"name":"Georgia Immunoengineering Consortium, Emory University and Georgia Institute of Technology , 950 Atlantic Drive, Atlanta, GA 30332 ,","place":["United States"]},{"name":"Winship Cancer Institute, Emory University , 1365 Clifton Road NE, Building C, Atlanta, GA 30332 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,3]]},"reference":[{"key":"2026082511561375700_qiag106-B1","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1038\/s41571-025-00992-5","article-title":"Outcome correlates of approved CD19-targeted CAR T cells for large B cell 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