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Neutrophils deploy microbicidal functions. However, it is unclear whether neutrophils in individuals with obesity function effectively against infections. To evaluate whether neutrophils in obesity have dysfunctional antimicrobial functions, neutrophils from individuals with normal weight and from individuals with obesity were isolated, and their phenotype and microbicidal functions were assessed. Neutrophils from individuals with obesity had higher expression of CD66b, CD11b, CD15, CD14, CD18, and CD182 on their membranes. The higher expression of these molecules correlated with higher body mass index, suggesting that obesity is associated with neutrophil activation. Accordingly, the phorbol 12-myristate 13-acetate (PMA)-induced respiratory burst in neutrophils from individuals with obesity was greater than in those from individuals without obesity, whereas phagocytosis and PMA-induced NETosis were comparable between neutrophils from individuals with or without obesity, implying that neutrophil functions are not impaired by obesity. However, neutrophil extracellular trap formation of neutrophils from individuals with obesity was selectively reduced in response to Staphylococcus aureus. Nevertheless, the actual killing of these bacteria was similar between neutrophils from individuals with or without obesity. In contrast, neutrophils from individuals with obesity exhibited impaired killing of Pseudomonas aeruginosa and of Klebsiella quasipneumoniae. Together, these findings suggest obesity induces neutrophil activation but disrupts pathogen-specific antimicrobial mechanisms of neutrophils. This deficiency in pathogen clearance could explain the increased susceptibility to infections observed in individuals with obesity.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag111","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:47:22Z","timestamp":1786016842000},"source":"Crossref","is-referenced-by-count":0,"title":["Obesity hampers bacteria killing by human neutrophils"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0808-3893","authenticated-orcid":false,"given":"Nathalia","family":"Naranjo-Pinto","sequence":"first","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Apartado Postal 70228, Ciudad de M\u00e9xico 04510 ,","place":["Mexico"]},{"name":"Posgrado en Ciencias Bioqu\u00edmicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Circuito Posgrado, Ed. 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Doctores, Ciudad de M\u00e9xico 06720 ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3502-7831","authenticated-orcid":false,"given":"Eileen","family":"Uribe-Querol","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda del Desarrollo, Divisi\u00f3n de Estudios de Posgrado e Investigaci\u00f3n, Facultad de Odontolog\u00eda, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Circuito Investigaci\u00f3n Cient\u00edfica 1853, Ciudad Universitaria, Ciudad de M\u00e9xico 04510 ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2568-5723","authenticated-orcid":false,"given":"Carlos","family":"Rosales","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Instituto de Investigaciones Biom\u00e9dicas, Universidad Nacional Aut\u00f3noma de M\u00e9xico , Apartado Postal 70228, Ciudad de M\u00e9xico 04510 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