{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:02:22Z","timestamp":1791198142719,"version":"4.1.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Secretar\u00eda de Investigaci\u00f3n y Posgrado"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mast cell (MC) degranulation is commonly viewed as the rapid release of preformed inflammatory mediators into the extracellular environment. In a recent study published in the Journal of Experimental Medicine, Salm et al. described a more spatially controlled form of MC communication following sterile peritoneal injury. Sensory neurons activated MCs through substance P signaling, promoting the release of extracellular granules that persisted as membraneless biomolecular condensates. These condensates, enriched in more than 200 proteins, remained associated with the surface of large peritoneal macrophages (LPMs), where they contributed to rapid macrophage aggregation through the scavenger receptor MARCO and promoted a repair-like phenotype at the injury site. Lattice light sheet microscopy further revealed F-actin-containing cytonemes that captured condensates from the MC surface and distributed them to surrounding macrophages. Importantly, disruption of this process impaired condensate dispersion, LPM recruitment, and wound healing. The study expands the conventional view of MC degranulation beyond the release of inflammatory soluble mediators by showing that released granules can remain organized and be actively positioned within injured tissue, creating a localized communication system between sensory neurons, MCs, and macrophages.<\/jats:p>","DOI":"10.1093\/jleuko\/qiag125","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:55:09Z","timestamp":1789455309000},"source":"Crossref","is-referenced-by-count":0,"title":["The light side of mast cell degranulation: delivering macrophage repair through molecular condensates"],"prefix":"10.1093","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7734-3253","authenticated-orcid":false,"given":"Alejandro","family":"Schcolnik-Cabrera","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology & Immunology, 6-020 Katz Group Centre for Pharmacy and Health Research, University of Alberta , Edmonton , AB T6G 2E1","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4500-0253","authenticated-orcid":false,"given":"Rommel","family":"Chac\u00f3n-Salinas","sequence":"additional","affiliation":[{"name":"Departamento de Inmunolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas, Instituto Polit\u00e9cnico Nacional (ENCB-IPN) , Prolongaci\u00f3n de Carpio y Plan de Ayala S\/N, Colonia Santo Tom\u00e1s, C.P. 11340, Mexico City ,","place":["Mexico"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,15]]},"reference":[{"key":"2026100506270535300_qiag125-B1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.685865","article-title":"Responses of mast cells to pathogens: beneficial and detrimental roles","volume":"12","author":"Jimenez","year":"2021","journal-title":"Front Immunol"},{"key":"2026100506270535300_qiag125-B2","doi-asserted-by":"publisher","first-page":"7294","DOI":"10.1038\/s41467-021-27614-9","article-title":"Directly recruited GATA6 + peritoneal cavity macrophages contribute to the repair of intestinal serosal injury","volume":"12","author":"Honda","year":"2021","journal-title":"Nat Commun"},{"key":"2026100506270535300_qiag125-B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.abe0595","article-title":"Primordial GATA6 macrophages function as extravascular platelets in sterile injury","volume":"371","author":"Zindel","year":"2021","journal-title":"Science"},{"key":"2026100506270535300_qiag125-B4","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.cell.2016.03.009","article-title":"A reservoir of mature cavity macrophages that can rapidly invade visceral organs to affect tissue repair","volume":"165","author":"Wang","year":"2016","journal-title":"Cell"},{"key":"2026100506270535300_qiag125-B5","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20260410","article-title":"A nerve and mast cell sentinel system releases extracellular condensates to induce macrophage repair","volume":"223","author":"Salm","year":"2026","journal-title":"J Exp Med"},{"key":"2026100506270535300_qiag125-B6","doi-asserted-by":"publisher","first-page":"1120","DOI":"10.1038\/s41589-026-02165-6","article-title":"Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine","volume":"22","author":"Xiong","year":"2026","journal-title":"Nat Chem Biol"},{"key":"2026100506270535300_qiag125-B7","doi-asserted-by":"publisher","first-page":"3981","DOI":"10.1172\/JCI85538","article-title":"Different activation signals induce distinct mast cell degranulation strategies","volume":"126","author":"Gaudenzio","year":"2016","journal-title":"J Clin Invest"},{"key":"2026100506270535300_qiag125-B8","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1038\/s41586-021-03563-7","article-title":"Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions","volume":"594","author":"Hoeffel","year":"2021","journal-title":"Nature"},{"key":"2026100506270535300_qiag125-B9","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1038\/s41586-024-07237-y","article-title":"CGRP sensory neurons promote tissue healing via neutrophils and macrophages","volume":"628","author":"Lu","year":"2024","journal-title":"Nature"},{"key":"2026100506270535300_qiag125-B10","doi-asserted-by":"publisher","first-page":"4406","DOI":"10.1038\/s41467-022-32080-y","article-title":"Gata6(+) resident peritoneal macrophages promote the growth of liver metastasis","volume":"13","author":"Hossain","year":"2022","journal-title":"Nat Commun"}],"container-title":["Journal of Leukocyte Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jleukbio\/advance-article-pdf\/doi\/10.1093\/jleuko\/qiag125\/71082920\/qiag125.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/10\/qiag125\/71082920\/qiag125.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jleukbio\/article-pdf\/118\/10\/qiag125\/71082920\/qiag125.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T10:27:12Z","timestamp":1791196032000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jleukbio\/article\/doi\/10.1093\/jleuko\/qiag125\/8795207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,15]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,5]]}},"URL":"https:\/\/doi.org\/10.1093\/jleuko\/qiag125","relation":{},"ISSN":["1938-3673"],"issn-type":[{"value":"1938-3673","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,9,15]]},"article-number":"qiag125"}}