{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:15:11Z","timestamp":1785248111636,"version":"3.55.0"},"reference-count":80,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology of China","award":["2018YFA0801004"],"award-info":[{"award-number":["2018YFA0801004"]}]},{"name":"Ministry of Science and Technology of China","award":["2018YFA0800103"],"award-info":[{"award-number":["2018YFA0800103"]}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC31530044"],"award-info":[{"award-number":["NSFC31530044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC31970780"],"award-info":[{"award-number":["NSFC31970780"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heart regeneration occurs by dedifferentiation and proliferation of pre-existing cardiomyocytes (CMs). However, the signaling mechanisms by which injury induces CM renewal remain incompletely understood. Here, we find that cardiac injury in zebrafish induces expression of the secreted Wnt inhibitors, including Dickkopf 1 (Dkk1), Dkk3, secreted Frizzled-related protein 1 (sFrp1), and sFrp2, in cardiac tissue adjacent to injury sites. Experimental blocking of Wnt activity via Dkk1 overexpression enhances CM proliferation and heart regeneration, whereas ectopic activation of Wnt8 signaling blunts injury-induced CM dedifferentiation and proliferation. Although Wnt signaling is dampened upon injury, the cytoplasmic \u03b2-catenin is unexpectedly increased at disarrayed CM sarcomeres in myocardial wound edges. Our analyses indicated that p21-activated kinase 2 (Pak2) is induced at regenerating CMs, where it phosphorylates cytoplasmic \u03b2-catenin at Ser 675 and increases its stability at disassembled sarcomeres. Myocardial-specific induction of the phospho-mimetic \u03b2-catenin (S675E) enhances CM dedifferentiation and sarcomere disassembly in response to injury. Conversely, inactivation of Pak2 kinase activity reduces the Ser 675-phosphorylated \u03b2-catenin (pS675-\u03b2-catenin) and attenuates CM sarcomere disorganization and dedifferentiation. Taken together, these findings demonstrate that coordination of Wnt signaling inhibition and Pak2\/pS675-\u03b2-catenin signaling enhances zebrafish heart regeneration by supporting CM dedifferentiation and proliferation.<\/jats:p>","DOI":"10.1093\/jmcb\/mjaa046","type":"journal-article","created":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T12:21:10Z","timestamp":1599222070000},"page":"41-58","source":"Crossref","is-referenced-by-count":31,"title":["Induction of Wnt signaling antagonists and p21-activated kinase enhances cardiomyocyte proliferation during zebrafish heart regeneration"],"prefix":"10.1093","volume":"13","author":[{"given":"Xiangwen","family":"Peng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhong Shan Hospital, Fudan University, Shanghai 200438, China"},{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai 200241, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaa Seng","family":"Lai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhong Shan Hospital, Fudan University, Shanghai 200438, China"},{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai 200241, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peilu","family":"She","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai 200241, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junsu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai 200241, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guobao","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering, School of Life Sciences, Zhong Shan Hospital, Fudan University, Shanghai 200438, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Zhou","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai 200241, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjian","family":"Sun","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai 200241, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daqing","family":"Jin","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai 200241, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN 55905, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lujian","family":"Liao","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai 200241, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiandong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Developmental and Cell Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth D","family":"Poss","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao P","family":"Zhong","sequence":"additional","affiliation":[{"name":"Shanghai Key Laboratory of Regulatory Biology, Institute of Molecular Medicine, East China Normal University School of Life Sciences, Shanghai 200241, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"2021103111470519300_mjaa046-B1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1093\/cvr\/cvr163","article-title":"Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43","volume":"92","author":"Ai","year":"2011","journal-title":"Cardiovasc. Res."},{"key":"2021103111470519300_mjaa046-B2","doi-asserted-by":"crossref","first-page":"3671","DOI":"10.1158\/0008-5472.CAN-12-4453","article-title":"Pak1 kinase links ErbB2 to \u03b2-catenin in transformation of breast epithelial cells","volume":"73","author":"Arias-Romero","year":"2013","journal-title":"Cancer Res."},{"key":"2021103111470519300_mjaa046-B3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00395-015-0481-x","article-title":"Dickkopf-3 protects against cardiac dysfunction and ventricular remodelling following myocardial infarction","volume":"110","author":"Bao","year":"2015","journal-title":"Basic Res. Cardiol."},{"key":"2021103111470519300_mjaa046-B4","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1161\/01.CIR.0000093186.22847.4C","article-title":"Reduction of infarct size and prevention of cardiac rupture in transgenic mice overexpressing FrzA","volume":"108","author":"Barandon","year":"2003","journal-title":"Circulation"},{"key":"2021103111470519300_mjaa046-B5","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"2021103111470519300_mjaa046-B6","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1126\/science.280.5363.596","article-title":"Functional interaction of an axin homolog, conductin, with \u03b2-catenin, APC, and GSK3\u03b2","volume":"280","author":"Behrens","year":"1998","journal-title":"Science"},{"key":"2021103111470519300_mjaa046-B7","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.110.223768","article-title":"WNT signaling in adult cardiac hypertrophy and remodeling: lessons learned from cardiac development","volume":"107","author":"Bergmann","year":"2010","journal-title":"Circ. Res."},{"key":"2021103111470519300_mjaa046-B8","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1146\/annurev.biochem.72.121801.161742","article-title":"Biology of the p21-activated kinases","volume":"72","author":"Bokoch","year":"2003","journal-title":"Annu. Rev. Biochem."},{"key":"2021103111470519300_mjaa046-B9","doi-asserted-by":"crossref","first-page":"13996","DOI":"10.1073\/pnas.0700947104","article-title":"pak2a mutations cause cerebral hemorrhage in redhead zebrafish","volume":"104","author":"Buchner","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B10","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1038\/nsmb.2139","article-title":"Crystal structures of the extracellular domain of LRP6 and its complex with DKK1","volume":"18","author":"Cheng","year":"2011","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2021103111470519300_mjaa046-B11","first-page":"1089","article-title":"Eph\u2013Pak2a signaling regulates branching of the pharyngeal endoderm by inhibiting late-stage epithelial dynamics","volume":"142","author":"Choe","year":"2015","journal-title":"Development"},{"key":"2021103111470519300_mjaa046-B12","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.stem.2013.10.003","article-title":"Distinct functions for Wnt\/\u03b2-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis","volume":"13","author":"Choi","year":"2013","journal-title":"Cell Stem Cell"},{"key":"2021103111470519300_mjaa046-B13","doi-asserted-by":"crossref","first-page":"7324","DOI":"10.4049\/jimmunol.172.12.7324","article-title":"A novel role for p21-activated protein kinase 2 in T cell activation","volume":"172","author":"Chu","year":"2004","journal-title":"J. Immunol."},{"key":"2021103111470519300_mjaa046-B14","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1634\/stemcells.2007-0768","article-title":"Activation of Wnt signaling in hematopoietic regeneration","volume":"26","author":"Congdon","year":"2008","journal-title":"Stem Cells"},{"key":"2021103111470519300_mjaa046-B15","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ncb3149","article-title":"ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation","volume":"17","author":"D'Uva","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"2021103111470519300_mjaa046-B16","doi-asserted-by":"crossref","first-page":"13416","DOI":"10.1073\/pnas.1309810110","article-title":"Translational profiling of cardiomyocytes identifies an early Jak1\/Stat3 injury response required for zebrafish heart regeneration","volume":"110","author":"Fang","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B17","doi-asserted-by":"crossref","first-page":"e14127","DOI":"10.1371\/journal.pone.0014127","article-title":"Independent interactions of phosphorylated \u03b2-catenin with E-cadherin at cell\u2012cell contacts and APC at cell protrusions","volume":"5","author":"Faux","year":"2010","journal-title":"PLoS One"},{"key":"2021103111470519300_mjaa046-B18","doi-asserted-by":"crossref","first-page":"e05871","DOI":"10.7554\/eLife.05871","article-title":"Nrg1 is an injury-induced cardiomyocyte mitogen for the endogenous heart regeneration program in zebrafish","volume":"4","author":"Gemberling","year":"2015","journal-title":"eLife"},{"key":"2021103111470519300_mjaa046-B19","doi-asserted-by":"crossref","first-page":"15853","DOI":"10.1073\/pnas.1120795109","article-title":"p21-activated kinase interacts with Wnt signaling to regulate tissue polarity and gene expression","volume":"109","author":"Goh","year":"2012","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B20","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cub.2013.05.028","article-title":"An injury-responsive gata4 program shapes the zebrafish cardiac ventricle","volume":"23","author":"Gupta","year":"2013","journal-title":"Curr. Biol."},{"key":"2021103111470519300_mjaa046-B21","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1073\/pnas.0835895100","article-title":"Stabilization of \u03b2-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth","volume":"100","author":"Haq","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B22","doi-asserted-by":"crossref","first-page":"4683","DOI":"10.1242\/dev.102798","article-title":"Hippo signaling impedes adult heart regeneration","volume":"140","author":"Heallen","year":"2013","journal-title":"Development"},{"key":"2021103111470519300_mjaa046-B23","doi-asserted-by":"crossref","first-page":"9063","DOI":"10.1128\/MCB.25.20.9063-9072.2005","article-title":"Phosphorylation of \u03b2-catenin by cyclic AMP-dependent protein kinase stabilizes \u03b2-catenin through inhibition of its ubiquitination","volume":"25","author":"Hino","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"2021103111470519300_mjaa046-B24","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/s00395-010-0101-8","article-title":"Stabilised \u03b2-catenin in postnatal ventricular myocardium leads to dilated cardiomyopathy and premature death","volume":"105","author":"Hirschy","year":"2010","journal-title":"Basic Res. Cardiol."},{"key":"2021103111470519300_mjaa046-B25","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/18899","article-title":"A new secreted protein that binds to Wnt proteins and inhibits their activities","volume":"398","author":"Hsieh","year":"1999","journal-title":"Nature"},{"key":"2021103111470519300_mjaa046-B26","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/dvdy.10356","article-title":"Germ-line transmission of a myocardium-specific GFP transgene reveals critical regulatory elements in the cardiac myosin light chain 2 promoter of zebrafish","volume":"228","author":"Huang","year":"2003","journal-title":"Dev. Dyn."},{"key":"2021103111470519300_mjaa046-B27","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/nature08899","article-title":"Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation","volume":"464","author":"Jopling","year":"2010","journal-title":"Nature"},{"key":"2021103111470519300_mjaa046-B28","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.devcel.2013.08.015","article-title":"Local Dkk1 crosstalk from breeding ornaments impedes regeneration of injured male zebrafish fins","volume":"27","author":"Kang","year":"2013","journal-title":"Dev. Cell"},{"key":"2021103111470519300_mjaa046-B29","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1101\/gad.1475106","article-title":"Wnt\/\u03b2-catenin signaling regulates vertebrate limb regeneration","volume":"20","author":"Kawakami","year":"2006","journal-title":"Genes Dev."},{"key":"2021103111470519300_mjaa046-B30","doi-asserted-by":"crossref","first-page":"84","DOI":"10.4161\/cl.21381","article-title":"Mouse models of PAK function","volume":"2","author":"Kelly","year":"2012","journal-title":"Cell. Logist."},{"key":"2021103111470519300_mjaa046-B31","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1007\/s00018-013-1347-8","article-title":"Role of p21-activated kinases in cardiovascular development and function","volume":"70","author":"Kelly","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"2021103111470519300_mjaa046-B32","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.devcel.2011.01.010","article-title":"Retinoic acid production by endocardium and epicardium is an injury response essential for zebrafish heart regeneration","volume":"20","author":"Kikuchi","year":"2011","journal-title":"Dev. Cell"},{"key":"2021103111470519300_mjaa046-B33","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nature08804","article-title":"Primary contribution to zebrafish heart regeneration by gata4+ cardiomyocytes","volume":"464","author":"Kikuchi","year":"2010","journal-title":"Nature"},{"key":"2021103111470519300_mjaa046-B34","doi-asserted-by":"crossref","first-page":"17206","DOI":"10.1073\/pnas.0915016107","article-title":"PDGF signaling is required for epicardial function and blood vessel formation in regenerating zebrafish hearts","volume":"107","author":"Kim","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B35","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.stem.2011.08.013","article-title":"Oncostatin M is a major mediator of cardiomyocyte dedifferentiation and remodeling","volume":"9","author":"Kubin","year":"2011","journal-title":"Cell Stem Cell"},{"key":"2021103111470519300_mjaa046-B36","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/dbio.2002.0711","article-title":"In vivo imaging of embryonic vascular development using transgenic zebrafish","volume":"248","author":"Lawson","year":"2002","journal-title":"Dev. Biol."},{"key":"2021103111470519300_mjaa046-B37","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cell.2006.08.052","article-title":"A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration","volume":"127","author":"Lepilina","year":"2006","journal-title":"Cell"},{"key":"2021103111470519300_mjaa046-B38","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0092-8674(00)81921-2","article-title":"Frzb-1 is a secreted antagonist of Wnt signaling expressed in the Spemann organizer","volume":"88","author":"Leyns","year":"1997","journal-title":"Cell"},{"key":"2021103111470519300_mjaa046-B39","doi-asserted-by":"crossref","first-page":"19883","DOI":"10.1074\/jbc.M413274200","article-title":"Sclerostin binds to LRP5\/6 and antagonizes canonical Wnt signaling","volume":"280","author":"Li","year":"2005","journal-title":"J. Biol. Chem."},{"key":"2021103111470519300_mjaa046-B40","doi-asserted-by":"crossref","first-page":"29105","DOI":"10.1074\/jbc.M113.510933","article-title":"FRAX597, a small molecule inhibitor of the p21-activated kinases, inhibits tumorigenesis of neurofibromatosis type 2 (NF2)-associated Schwannomas","volume":"288","author":"Licciulli","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2021103111470519300_mjaa046-B41","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","article-title":"Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model","volume":"115","author":"Lin","year":"2014","journal-title":"Circ. Res."},{"key":"2021103111470519300_mjaa046-B42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"2021103111470519300_mjaa046-B43","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","article-title":"The Wnt signaling pathway in development and disease","volume":"20","author":"Logan","year":"2004","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"2021103111470519300_mjaa046-B44","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/j.cub.2003.11.055","article-title":"Heart of glass regulates the concentric growth of the heart in zebrafish","volume":"13","author":"Mably","year":"2003","journal-title":"Curr. Biol."},{"key":"2021103111470519300_mjaa046-B45","doi-asserted-by":"crossref","first-page":"11237","DOI":"10.1073\/pnas.1605431113","article-title":"Fast revascularization of the injured area is essential to support zebrafish heart regeneration","volume":"113","author":"Marin-Juez","year":"2016","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B46","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.cell.2018.02.014","article-title":"Regulation of cell cycle to stimulate adult cardiomyocyte proliferation and cardiac regeneration","volume":"173","author":"Mohamed","year":"2018","journal-title":"Cell"},{"key":"2021103111470519300_mjaa046-B47","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1073\/pnas.1621346114","article-title":"Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist","volume":"114","author":"Moon","year":"2017","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B48","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ydbio.2012.03.023","article-title":"In vivo Wnt signaling tracing through a transgenic biosensor fish reveals novel activity domains","volume":"366","author":"Moro","year":"2012","journal-title":"Dev. Biol."},{"key":"2021103111470519300_mjaa046-B49","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1242\/dev.143362","article-title":"Notch signalling restricts inflammation and serpine1 expression in the dynamic endocardium of the regenerating zebrafish heart","volume":"144","author":"Munch","year":"2017","journal-title":"Development"},{"key":"2021103111470519300_mjaa046-B50","doi-asserted-by":"crossref","first-page":"19812","DOI":"10.1073\/pnas.0605768103","article-title":"Developmental stage-specific biphasic roles of Wnt\/\u03b2-catenin signaling in cardiomyogenesis and hematopoiesis","volume":"103","author":"Naito","year":"2006","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B51","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1126\/science.1094291","article-title":"Convergence of Wnt, \u03b2-catenin, and cadherin pathways","volume":"303","author":"Nelson","year":"2004","journal-title":"Science"},{"key":"2021103111470519300_mjaa046-B52","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1016\/j.chembiol.2011.09.015","article-title":"Discovering small molecules that promote cardiomyocyte generation by modulating Wnt signaling","volume":"18","author":"Ni","year":"2011","journal-title":"Chem. Biol."},{"key":"2021103111470519300_mjaa046-B53","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13619-015-0017-8","article-title":"Wnt\/\u03b2-catenin signaling in heart regeneration","volume":"4","author":"Ozhan","year":"2015","journal-title":"Cell Regen."},{"key":"2021103111470519300_mjaa046-B54","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.bbrc.2016.03.011","article-title":"Rac1\u2012PAK2 pathway is essential for zebrafish heart regeneration","volume":"472","author":"Peng","year":"2016","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021103111470519300_mjaa046-B55","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1126\/science.1200708","article-title":"Transient regenerative potential of the neonatal mouse heart","volume":"331","author":"Porrello","year":"2011","journal-title":"Science"},{"key":"2021103111470519300_mjaa046-B56","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1126\/science.1077857","article-title":"Heart regeneration in zebrafish","volume":"298","author":"Poss","year":"2002","journal-title":"Science"},{"key":"2021103111470519300_mjaa046-B57","doi-asserted-by":"crossref","first-page":"588","DOI":"10.2337\/diabetes.52.3.588","article-title":"Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo","volume":"52","author":"Ring","year":"2003","journal-title":"Diabetes"},{"key":"2021103111470519300_mjaa046-B58","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ydbio.2014.12.002","article-title":"A dual epimorphic and compensatory mode of heart regeneration in zebrafish","volume":"399","author":"Sallin","year":"2015","journal-title":"Dev. Biol."},{"key":"2021103111470519300_mjaa046-B59","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1101\/gad.1760809","article-title":"Wnt signaling pathways meet Rho GTPases","volume":"23","author":"Schlessinger","year":"2009","journal-title":"Genes Dev."},{"key":"2021103111470519300_mjaa046-B60","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature11682","article-title":"Mammalian heart renewal by pre-existing cardiomyocytes","volume":"493","author":"Senyo","year":"2013","journal-title":"Nature"},{"key":"2021103111470519300_mjaa046-B61","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1038\/s41467-018-06617-z","article-title":"A conserved HH\u2012Gli1\u2012Mycn network regulates heart regeneration from newt to human","volume":"9","author":"Singh","year":"2018","journal-title":"Nat. Commun."},{"key":"2021103111470519300_mjaa046-B62","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1242\/dev.001123","article-title":"Distinct Wnt signaling pathways have opposing roles in appendage regeneration","volume":"134","author":"Stoick-Cooper","year":"2007","journal-title":"Development"},{"key":"2021103111470519300_mjaa046-B63","doi-asserted-by":"crossref","first-page":"9971","DOI":"10.1074\/jbc.M508778200","article-title":"Phosphorylation of \u03b2-catenin by cyclic AMP-dependent protein kinase","volume":"281","author":"Taurin","year":"2006","journal-title":"J. Biol. Chem."},{"key":"2021103111470519300_mjaa046-B64","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1126\/science.aam5894","article-title":"Cardiac regeneration strategies: staying young at heart","volume":"356","author":"Tzahor","year":"2017","journal-title":"Science"},{"key":"2021103111470519300_mjaa046-B65","doi-asserted-by":"crossref","first-page":"9685","DOI":"10.1073\/pnas.0702859104","article-title":"Biphasic role for Wnt\/\u03b2-catenin signaling in cardiac specification in zebrafish and embryonic stem cells","volume":"104","author":"Ueno","year":"2007","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B66","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1038\/emboj.2012.150","article-title":"The many faces and functions of \u03b2-catenin","volume":"31","author":"Valenta","year":"2012","journal-title":"EMBO J."},{"key":"2021103111470519300_mjaa046-B67","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1002\/dvdy.22019","article-title":"Regulation of Wnt\/\u03b2-catenin signaling by protein kinases","volume":"239","author":"Verheyen","year":"2010","journal-title":"Dev. Dyn."},{"key":"2021103111470519300_mjaa046-B68","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3109\/15419061.2014.908853","article-title":"N-cadherin\/catenin complex as a master regulator of intercalated disc function","volume":"21","author":"Vite","year":"2014","journal-title":"Cell Commun. Adhes."},{"key":"2021103111470519300_mjaa046-B69","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature14325","article-title":"Epicardial regeneration is guided by cardiac outflow tract and Hedgehog signalling","volume":"522","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"2021103111470519300_mjaa046-B70","doi-asserted-by":"crossref","first-page":"3421","DOI":"10.1242\/dev.068601","article-title":"The regenerative capacity of zebrafish reverses cardiac failure caused by genetic cardiomyocyte depletion","volume":"138","author":"Wang","year":"2011","journal-title":"Development"},{"key":"2021103111470519300_mjaa046-B71","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1161\/CIRCULATIONAHA.116.024441","article-title":"Opposing roles of Wnt inhibitors IGFBP-4 and Dkk1 in cardiac ischemia by differential targeting of LRP5\/6 and \u03b2-catenin","volume":"134","author":"Wo","year":"2016","journal-title":"Circulation"},{"key":"2021103111470519300_mjaa046-B72","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.devcel.2015.12.010","article-title":"Spatially resolved genome-wide transcriptional profiling identifies BMP signaling as essential regulator of zebrafish cardiomyocyte regeneration","volume":"36","author":"Wu","year":"2016","journal-title":"Dev. Cell"},{"key":"2021103111470519300_mjaa046-B73","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/jmcb\/mjz023","article-title":"Discovering small molecules as Wnt inhibitors that promote heart regeneration and injury repair","volume":"12","author":"Xie","year":"2020","journal-title":"J. Mol. Cell Biol."},{"key":"2021103111470519300_mjaa046-B74","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nrm3619","article-title":"Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair","volume":"14","author":"Xin","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2021103111470519300_mjaa046-B75","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1042\/CS20171256","article-title":"Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction","volume":"131","author":"Yang","year":"2017","journal-title":"Clin. Sci."},{"key":"2021103111470519300_mjaa046-B76","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1096\/fj.12-207969","article-title":"\u03b1-actinin2 is required for the lateral alignment of Z discs and ventricular chamber enlargement during zebrafish cardiogenesis","volume":"26","author":"Yang","year":"2012","journal-title":"FASEB J."},{"key":"2021103111470519300_mjaa046-B77","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.celrep.2018.12.048","article-title":"Endocardial Notch signaling promotes cardiomyocyte proliferation in the regenerating zebrafish heart through Wnt pathway antagonism","volume":"26","author":"Zhao","year":"2019","journal-title":"Cell Rep."},{"key":"2021103111470519300_mjaa046-B78","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1073\/pnas.1311705111","article-title":"Notch signaling regulates cardiomyocyte proliferation during zebrafish heart regeneration","volume":"111","author":"Zhao","year":"2014","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2021103111470519300_mjaa046-B79","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/onc.2011.294","article-title":"A Rac1\/PAK1 cascade controls \u03b2-catenin activation in colon cancer cells","volume":"31","author":"Zhu","year":"2012","journal-title":"Oncogene"},{"key":"2021103111470519300_mjaa046-B80","doi-asserted-by":"crossref","first-page":"a008086","DOI":"10.1101\/cshperspect.a008086","article-title":"Targeting Wnt pathways in disease","volume":"4","author":"Zimmerman","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."}],"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjaa046\/36252856\/mjaa046.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jmcb\/article-pdf\/13\/1\/41\/40935423\/mjaa046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jmcb\/article-pdf\/13\/1\/41\/40935423\/mjaa046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,13]],"date-time":"2024-08-13T05:36:15Z","timestamp":1723527375000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/article\/13\/1\/41\/5906155"}},"subtitle":[],"editor":[{"given":"Anming","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,16]]},"references-count":80,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,9,16]]},"published-print":{"date-parts":[[2021,4,10]]}},"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mjaa046","relation":{},"ISSN":["1759-4685"],"issn-type":[{"value":"1759-4685","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,1,1]]},"published":{"date-parts":[[2020,9,16]]}}}