{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T09:20:42Z","timestamp":1762161642614,"version":"3.37.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T00:00:00Z","timestamp":1614902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570768","31900841","91957205","31525012","81471016"],"award-info":[{"award-number":["81570768","31900841","91957205","31525012","81471016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology of China","award":["2016YFA0500102","2016YFC1304905"],"award-info":[{"award-number":["2016YFA0500102","2016YFC1304905"]}]},{"name":"CAS Key Laboratory of Nutrition, Metabolism and Food Safety","award":["KLNMFS2019-01"],"award-info":[{"award-number":["KLNMFS2019-01"]}]},{"name":"Chinese Academy of Sciences Interdisciplinary Innovation Team"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Muscle regeneration after damage or during myopathies requires a fine cooperation between myoblast proliferation and myogenic differentiation. A growing body of evidence suggests that microRNAs play critical roles in myocyte proliferation and differentiation transcriptionally. However, the molecular mechanisms underlying the orchestration are not fully understood. Here, we showed that miR-130b is able to repress myoblast proliferation and promote myogenic differentiation via targeting Sp1 transcription factor. Importantly, overexpression of miR-130b is capable of improving the recovery of damaged muscle in a freeze injury model. Moreover, miR-130b expression is declined in the muscle of muscular dystrophy patients. Thus, these results indicated that miR-130b may play a role in skeletal muscle regeneration and myopathy progression. Together, our findings suggest that the miR-130b\/Sp1 axis may serve as a potential therapeutic target for the treatment of patients with muscle damage or severe myopathies.<\/jats:p>","DOI":"10.1093\/jmcb\/mjab012","type":"journal-article","created":{"date-parts":[[2021,3,3]],"date-time":"2021-03-03T12:17:11Z","timestamp":1614773831000},"page":"422-432","source":"Crossref","is-referenced-by-count":10,"title":["miR-<b>130<\/b>b inhibits proliferation and promotes differentiation in myocytes via targeting Sp<b>1<\/b>"],"prefix":"10.1093","volume":"13","author":[{"given":"Yu-Cheng","family":"Wang","sequence":"first","affiliation":[{"name":"Shanghai Xuhui District Central Hospital, Zhongshan-Xuhui Hospital, Fudan University, Shanghai 200001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohan","family":"Yao","sequence":"additional","affiliation":[{"name":"CAS Key laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Disease, Children\u2019s Hospital of Fudan University, Shanghai 201102, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengnan","family":"Liu","sequence":"additional","affiliation":[{"name":"CAS Key laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Sun","sequence":"additional","affiliation":[{"name":"CAS Key laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"CAS Key laboratory of Nutrition, 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