{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T19:49:36Z","timestamp":1793821776102,"version":"4.6.1"},"reference-count":109,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":18,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The cyclic GMP\u2012AMP synthase (cGAS)\u2012stimulator of interferon genes (STING) signaling pathway senses the presence of cytosolic DNA and, in turn, triggers downstream signaling to induce the expression of inflammatory and type I interferon genes in immune cells. Whereas the innate immune function of the cGAS\u2012STING pathway is well studied over the past years, emerging evidence suggests that this signaling pathway may have additional functions beyond innate immune surveillance. Consistent with this notion, dysregulation of the cGAS\u2012STING signaling pathway in adipocytes, hepatocytes, and renal proximal tubule epithelial cells are associated with metabolic dysfunction, impaired energy homeostasis, and kidney diseases. In this review, we summarize current understanding of the cGAS\u2012STING pathway in several metabolic diseases such as obesity, insulin resistance, alcoholic and nonalcoholic fatty liver diseases, as well as acute kidney injury and chronic kidney disease. We also review the interaction between the cGAS\u2012STING pathway and lipid metabolism. Lastly, we discuss potential mechanisms by which cGAS\u2012STING signaling regulates metabolism and point toward future avenues of research targeting the cGAS\u2012STING pathway as possible means to treat common metabolic disorders.<\/jats:p>","DOI":"10.1093\/jmcb\/mjab066","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:52:41Z","timestamp":1634345561000},"page":"728-738","source":"Crossref","is-referenced-by-count":99,"title":["cGAS\u2012STING signaling and function in metabolism and kidney diseases"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1193-8155","authenticated-orcid":false,"given":"Juli","family":"Bai","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"},{"name":"National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5098-1711","authenticated-orcid":false,"given":"Feng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Texas Health at San Antonio, San Antonio, TX 78229, USA"},{"name":"National Clinical Research Center for Metabolic Diseases, Metabolic Syndrome Research Center, Key Laboratory of Diabetes Immunology, Ministry of Education, and Department of Metabolism and Endocrinology, The Second Xiangya Hospital of Central South University, Changsha 410011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"2021123022214006100_mjab066-B1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nature12640","article-title":"Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP","volume":"503","author":"Ablasser","year":"2013","journal-title":"Nature"},{"key":"2021123022214006100_mjab066-B2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41581-019-0211-y","article-title":"STING activation by cytoplasmic mtDNA triggers renal inflammation and fibrosis","volume":"15","author":"Allison","year":"2019","journal-title":"Nat. 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Clin. Invest"},{"key":"2021123022214006100_mjab066-B43","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1038\/82219","article-title":"Statins as a newly recognized type of immunomodulator","volume":"6","author":"Kwak","year":"2000","journal-title":"Nat. Med"},{"key":"2021123022214006100_mjab066-B44","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.cell.2018.08.062","article-title":"NONO detects the nuclear HIV capsid to promote cGAS-mediated innate immune activation","volume":"175","author":"Lahaye","year":"2018","journal-title":"Cell"},{"key":"2021123022214006100_mjab066-B45","doi-asserted-by":"crossref","first-page":"G655","DOI":"10.1152\/ajpgi.00326.2017","article-title":"cGAS-mediated autophagy protects the liver from ischemia\u2012reperfusion injury independently of STING","volume":"314","author":"Lei","year":"2018","journal-title":"Am. J. Physiol. Gastrointest. 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Lipid Res"},{"key":"2021123022214006100_mjab066-B59","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.semnephrol.2019.10.007","article-title":"Pathophysiological role of organelle stress\/crosstalk in AKI-to-CKD transition","volume":"39","author":"Maekawa","year":"2019","journal-title":"Semin. Nephrol"},{"key":"2021123022214006100_mjab066-B60","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.celrep.2019.09.050","article-title":"Mitochondrial damage causes inflammation via cGAS\u2012STING signaling in acute kidney injury","volume":"29","author":"Maekawa","year":"2019","journal-title":"Cell Rep"},{"key":"2021123022214006100_mjab066-B61","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fmed.2020.00467","article-title":"Disturbances in cholesterol homeostasis and non-alcoholic fatty liver diseases","volume":"7","author":"Malhotra","year":"2020","journal-title":"Front. 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