{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:19:00Z","timestamp":1790824740394,"version":"4.1.0"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2022,10,22]],"date-time":"2022-10-22T00:00:00Z","timestamp":1666396800000},"content-version":"vor","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"French National Research Agency","doi-asserted-by":"publisher","award":["ANR-10-INBS-04"],"award-info":[{"award-number":["ANR-10-INBS-04"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,3,29]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Understanding how certain animals are capable of regenerating their hearts will provide much needed insights into how this process can be induced in humans in order to reverse the damage caused by myocardial infarction. Currently, it is becoming increasingly evident that cardiac interstitial cells play crucial roles during cardiac regeneration. To understand how interstitial cells behave during this process, we performed single-cell RNA sequencing of regenerating zebrafish hearts. Using a combination of immunohistochemistry, chemical inhibition, and novel transgenic animals, we were able to investigate the role of cell type-specific mechanisms during cardiac regeneration. This approach allowed us to identify a number of important regenerative processes within the interstitial cell populations. Here, we provide detailed insight into how interstitial cells behave during cardiac regeneration, which will serve to increase our understanding of how this process could eventually be induced in humans.<\/jats:p>","DOI":"10.1093\/jmcb\/mjac059","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T11:48:59Z","timestamp":1666266539000},"source":"Crossref","is-referenced-by-count":14,"title":["The regenerative response of cardiac interstitial cells"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1261-3384","authenticated-orcid":false,"given":"Laura","family":"Rolland","sequence":"first","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alenca","family":"Harrington","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ad\u00e8le","family":"Faucherre","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jourdano Mancilla","family":"Abaroa","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girisaran","family":"Gangatharan","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Gamba","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dany","family":"Severac","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"},{"name":"Montpellier GenomiX, France G\u00e9nomique , Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Pratlong","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"},{"name":"Montpellier GenomiX, France G\u00e9nomique , Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Moore-Morris","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0950-0063","authenticated-orcid":false,"given":"Chris","family":"Jopling","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics, University of Montpellier , CNRS, INSERM, LabEx ICST, Montpellier 34094 , France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,10,22]]},"reference":[{"key":"2023041908113967100_bib1","doi-asserted-by":"crossref","first-page":"e57920","DOI":"10.7554\/eLife.57920","article-title":"Macrophages promote endothelial-to-mesenchymal transition via MT1-MMP\/TGF\u03b21 after myocardial infarction","volume":"9","author":"Alonso-Herranz","year":"2020","journal-title":"eLife"},{"key":"2023041908113967100_bib2","doi-asserted-by":"crossref","first-page":"dev183954","DOI":"10.1242\/dev.183954","article-title":"MMP14 is required for delamination of chick neural crest cells independently of its catalytic activity","volume":"147","author":"Andrieu","year":"2020","journal-title":"Development"},{"key":"2023041908113967100_bib3","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1002\/j.1460-2075.1992.tb05500.x","article-title":"The SCL gene product: a positive regulator of erythroid differentiation","volume":"11","author":"Aplan","year":"1992","journal-title":"EMBO J."},{"key":"2023041908113967100_bib4","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1172\/JCI72181","article-title":"Macrophages are required for neonatal heart regeneration","volume":"124","author":"Aurora","year":"2014","journal-title":"J. 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