{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:45:28Z","timestamp":1777513528512,"version":"3.51.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371479"],"award-info":[{"award-number":["31371479"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>YPEL5 is a member of the Yippee-like (YPEL) gene family that is evolutionarily conserved in eukaryotic species. To date, the physiological function of YPEL5 has not been assessed due to a paucity of genetic animal models. Here, using CRISPR\/Cas9-mediated genome editing, we generated a stable ypel5\u2212\/\u2212 mutant zebrafish line. Disruption of ypel5 expression leads to liver enlargement associated with hepatic cell proliferation. Meanwhile, hepatic metabolism and function are dysregulated in ypel5\u2212\/\u2212 mutant zebrafish, as revealed by metabolomic and transcriptomic analyses. Mechanistically, Hnf4a is identified as a crucial downstream mediator that is positively regulated by Ypel5. Zebrafish hnf4a overexpression could largely rescue ypel5 deficiency-induced hepatic defects. Furthermore, PPAR\u03b1 signaling mediates the regulation of Hnf4a by Ypel5 through directly binding to the transcriptional enhancer of the Hnf4a gene. Herein, this work demonstrates an essential role of Ypel5 in hepatocyte proliferation and function and provides the first in vivo evidence for a physiological role of the ypel5 gene in vertebrates.<\/jats:p>","DOI":"10.1093\/jmcb\/mjad019","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T01:23:09Z","timestamp":1679534589000},"source":"Crossref","is-referenced-by-count":3,"title":["Ypel5 regulates liver development and function in zebrafish"],"prefix":"10.1093","volume":"15","author":[{"given":"Yun","family":"Deng","sequence":"first","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"CNRS-LIA Hematology and Cancer, Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of 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National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"CNRS-LIA Hematology and Cancer, Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugues","family":"de The","sequence":"additional","affiliation":[{"name":"CNRS-LIA Hematology and Cancer, Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"Universit\u00e9 de Paris 7\/INSERM\/CNRS UMR 944\/7212, Equipe Labellis\u00e9e Ligue Nationale Contre le Cancer, H\u00f4pital St. Louis , Paris 75010 , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"CNRS-LIA Hematology and Cancer, Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"Universit\u00e9 de Paris 7\/INSERM\/CNRS UMR 944\/7212, Equipe Labellis\u00e9e Ligue Nationale Contre le Cancer, H\u00f4pital St. Louis , Paris 75010 , France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7976-7762","authenticated-orcid":false,"given":"Hao","family":"Yuan","sequence":"additional","affiliation":[{"name":"Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , China"},{"name":"CNRS-LIA Hematology and Cancer, Sino-French Research Center for Life Sciences and Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 , 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