{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T14:34:23Z","timestamp":1793025263821,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T00:00:00Z","timestamp":1685232000000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070913"],"award-info":[{"award-number":["82070913"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shanghai Science and Technology Development Funds","award":["20ZR1446000"],"award-info":[{"award-number":["20ZR1446000"]}]},{"name":"Shanghai Science and Technology Development Funds","award":["22410713200"],"award-info":[{"award-number":["22410713200"]}]},{"name":"Shanghai Fourth People's Hospital","award":["sykyqd01801"],"award-info":[{"award-number":["sykyqd01801"]}]},{"name":"Shanghai Key Laboratory of Diabetes Mellitus","award":["SHKLD-KF-2101"],"award-info":[{"award-number":["SHKLD-KF-2101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hyperglycaemia-induced oxidative stress may disrupt insulin secretion and \u03b2-cell survival in diabetes mellitus by overproducing reactive oxygen species. Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) exhibit antioxidant properties. However, the mechanisms by which hUC-MSCs protect \u03b2-cells from high glucose-induced oxidative stress remain underexplored. In this study, we showed that intravenously injected hUC-MSCs engrafted into the injured pancreas and promoted pancreatic \u03b2-cell function in a mouse model of type 1 diabetes mellitus. The in vitro study revealed that hUC-MSCs attenuated high glucose-induced oxidative stress and prevented \u03b2-cell impairment via the Nrf2\/HO-1 signalling pathway. Nrf2 knockdown partially blocked the anti-oxidative effect of hUC-MSCs, resulting in \u03b2-cell decompensation in a high-glucose environment. Overall, these findings provide novel insights into how hUC-MSCs protect \u03b2-cells from high glucose-induced oxidative stress.<\/jats:p>","DOI":"10.1093\/jmcb\/mjad035","type":"journal-article","created":{"date-parts":[[2023,5,28]],"date-time":"2023-05-28T04:07:25Z","timestamp":1685246845000},"source":"Crossref","is-referenced-by-count":17,"title":["Human umbilical cord-derived mesenchymal stem cells alleviate oxidative stress-induced islet impairment via the Nrf2\/HO-1 axis"],"prefix":"10.1093","volume":"15","author":[{"given":"Peng","family":"Liu","sequence":"first","affiliation":[{"name":"Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine , Shanghai 200233 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baige","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Metabolism, Shanghai Fourth People's Hospital, School of Medicine, Tongji University , Shanghai 200434 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6967-421X","authenticated-orcid":false,"given":"Yang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Translational Medical Center for Stem Cell Therapy, Shanghai East Hospital, School of Medicine, Tongji University , Shanghai 200092 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huina","family":"Zhang","sequence":"additional","affiliation":[{"name":"Stem Cell Translational Research Center, Tongji Hospital, School of Medicine, Tongji University , Shanghai 200065 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congrong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology & Metabolism, Shanghai Fourth People's Hospital, School of Medicine, Tongji University , Shanghai 200434 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,27]]},"reference":[{"key":"2024011909181191000_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrendo.2009.274","article-title":"Stem cell therapy for type 1 diabetes mellitus","volume":"6","author":"Aguayo-Mazzucato","year":"2010","journal-title":"Nat. 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