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However, the inappropriate activation of these signaling pathways is implicated in autoimmune conditions. Here, we report that indomethacin, a widely used nonsteroidal anti-inflammatory drug, inhibits nucleic acid-triggered IFN production. We found that both DNA- and RNA-stimulated IFN expression can be effectively blocked by indomethacin. Interestingly, indomethacin also prohibits the nuclear translocation of IRF3 following cytosolic nucleic acid recognition. Importantly, in cell lines and a mouse model of Aicardi\u2013Gouti\u00e8res syndrome, indomethacin administration blunts self-DNA-induced autoimmune responses. Thus, our study reveals a previously unknown function of indomethacin and provides a potential treatment for cytosolic nucleic acid-stimulated autoimmunity.<\/jats:p>","DOI":"10.1093\/jmcb\/mjae015","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T15:18:58Z","timestamp":1712243938000},"source":"Crossref","is-referenced-by-count":2,"title":["Indomethacin restrains cytoplasmic nucleic acid-stimulated immune responses by inhibiting the nuclear translocation of IRF3"],"prefix":"10.1093","volume":"16","author":[{"given":"Miao","family":"Wang","sequence":"first","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100850 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100850 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