{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:45:45Z","timestamp":1792014345997,"version":"4.4.0"},"reference-count":74,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T00:00:00Z","timestamp":1715644800000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Science and Technology of China","award":["2019YFA0802804"],"award-info":[{"award-number":["2019YFA0802804"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31871492"],"award-info":[{"award-number":["31871492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32270837"],"award-info":[{"award-number":["32270837"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003819","name":"Hubei Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023AFB784"],"award-info":[{"award-number":["2023AFB784"]}],"id":[{"id":"10.13039\/501100003819","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042022kf1146"],"award-info":[{"award-number":["2042022kf1146"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2042022dx0003"],"award-info":[{"award-number":["2042022dx0003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The mammary gland is a dynamic organ that undergoes significant changes at multiple stages of postnatal development. Although the roles of systemic hormones and microenvironmental cues in mammary homeostasis have been extensively studied, the influence of neural signals, particularly those from the sympathetic nervous system, remains poorly understood. Here, using a mouse mammary gland model, we delved into the regulatory role of sympathetic nervous signaling in the context of mammary stem cells and mammary development. Our findings revealed that depletion of sympathetic nerve signals results in defective mammary development during puberty, adulthood, and pregnancy, accompanied by a reduction in mammary stem cell numbers. Through in vitro three-dimensional culture and in vivo transplantation analyses, we demonstrated that the absence of sympathetic nerve signals hinders mammary stem cell self-renewal and regeneration, while activation of sympathetic nervous signaling promotes these capacities. Mechanistically, sympathetic nerve signals orchestrate mammary stem cell activity and mammary development through the extracellular signal-regulated kinase signaling pathway. Collectively, our study unveils the crucial roles of sympathetic nerve signals in sustaining mammary development and regulating mammary stem cell activity, offering a novel perspective on the involvement of the nervous system in modulating adult stem cell function and organ development.<\/jats:p>","DOI":"10.1093\/jmcb\/mjae020","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T01:38:14Z","timestamp":1715650694000},"source":"Crossref","is-referenced-by-count":7,"title":["Sympathetic nerve signals: orchestrators of mammary development and stem cell vitality"],"prefix":"10.1093","volume":"16","author":[{"given":"Zi","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Pulmonary Oncology, Hubei Province Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University ; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Oncology, Hubei Province Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University ; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengna","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , Hangzhou 310024 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3712-1696","authenticated-orcid":false,"given":"Cheguo","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Oncology, Hubei Province Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Zhongnan Hospital of Wuhan University ; Frontier Science Center for Immunology and Metabolism, Medical Research Institute, Wuhan University, Wuhan 430071 ,","place":["China"]},{"name":"Key Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences , Hangzhou 310024 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"2024112311062171800_bib1","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/nature09027","article-title":"Control of mammary stem cell function by steroid hormone signalling","volume":"465","author":"Asselin-Labat","year":"2010","journal-title":"Nature"},{"key":"2024112311062171800_bib2","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.3390\/cancers12061697","article-title":"Influence of fibroblasts on mammary gland development, breast cancer microenvironment remodeling, and cancer cell dissemination","volume":"12","author":"Avagliano","year":"2020","journal-title":"Cancers"},{"key":"2024112311062171800_bib3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrm3721","article-title":"Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration","volume":"15","author":"Barker","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2024112311062171800_bib4","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.celrep.2013.06.019","article-title":"Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation","volume":"4","author":"Borden","year":"2013","journal-title":"Cell Rep."},{"key":"2024112311062171800_bib5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1289\/ehp.898085","article-title":"Growth control and differentiation in mammary epithelial cells","volume":"80","author":"Borellini","year":"1989","journal-title":"Environ. Health Perspect."},{"key":"2024112311062171800_bib6","doi-asserted-by":"crossref","first-page":"e35538","DOI":"10.1371\/journal.pone.0035538","article-title":"Mouse estrous cycle identification tool and images","volume":"7","author":"Byers","year":"2012","journal-title":"PLoS One"},{"key":"2024112311062171800_bib7","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1007\/s00280-008-0689-7","article-title":"Interleukin-6 protects against paclitaxel, cisplatin and vincristine-induced neuropathies without impairing chemotherapeutic activity","volume":"62","author":"Callizot","year":"2008","journal-title":"Cancer Chemother. Pharmacol."},{"key":"2024112311062171800_bib8","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s00441-020-03355-x","article-title":"Niacin stimulates EPH4EV mammary epithelial cell proliferation and mammary gland development in pubertal mice through activation of AKT\/mTOR and ERK1\/2 signaling pathways","volume":"384","author":"Cao","year":"2021","journal-title":"Cell Tissue Res."},{"key":"2024112311062171800_bib9","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbi.2016.06.011","article-title":"\u03b22-Adrenoceptors on tumor cells play a critical role in stress-enhanced metastasis in a mouse model of breast cancer","volume":"57","author":"Chang","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"2024112311062171800_bib10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1530\/ERC-14-0236","article-title":"Adrenergic signaling promotes angiogenesis through endothelial cell\u2013tumor cell crosstalk","volume":"21","author":"Chen","year":"2014","journal-title":"Endocr. Relat. Cancer"},{"key":"2024112311062171800_bib11","doi-asserted-by":"crossref","first-page":"1248012","DOI":"10.1126\/science.1248012","article-title":"An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control","volume":"346","author":"Clevers","year":"2014","journal-title":"Science"},{"key":"2024112311062171800_bib12","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc3978","article-title":"Sympathetic nervous system regulation of the tumour microenvironment","volume":"15","author":"Cole","year":"2015","journal-title":"Nat. Rev. Cancer"},{"key":"2024112311062171800_bib13","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.devcel.2021.05.018","article-title":"Niches that regulate stem cells and hematopoiesis in adult bone marrow","volume":"56","author":"Comazzetto","year":"2021","journal-title":"Dev. Cell"},{"key":"2024112311062171800_bib14","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41413-021-00137-1","article-title":"Sympathetic activity in breast cancer and metastasis: partners in crime","volume":"9","author":"Conceicao","year":"2021","journal-title":"Bone Res"},{"key":"2024112311062171800_bib15","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/dvdy.10065","article-title":"Adipose tissue: a vital in vivo role in mammary gland development but not differentiation","volume":"223","author":"Couldrey","year":"2002","journal-title":"Dev. Dyn."},{"key":"2024112311062171800_bib16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.biocel.2019.01.004","article-title":"Sympathetic nervous system in age-related cardiovascular dysfunction: pathophysiology and therapeutic perspective","volume":"108","author":"de Lucia","year":"2019","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2024112311062171800_bib17","first-page":"595","article-title":"The sympathetic nerve\u2014an integrative interface between two supersystems: the brain and the immune system","volume":"52","author":"Elenkov","year":"2000","journal-title":"Pharmacol. Rev."},{"key":"2024112311062171800_bib18","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s10911-019-09439-x","article-title":"Redirecting normal and cancer stem cells to a mammary epithelial cell fate","volume":"24","author":"Frank-Kamenetskii","year":"2019","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"2024112311062171800_bib19","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1152\/physrev.00040.2018","article-title":"Stem cells and the differentiation hierarchy in mammary gland development","volume":"100","author":"Fu","year":"2020","journal-title":"Physiol. Rev."},{"key":"2024112311062171800_bib20","doi-asserted-by":"crossref","first-page":"e63","DOI":"10.1016\/j.clbc.2020.06.011","article-title":"The role of immune cells in breast tissue and immunotherapy for the treatment of breast cancer","volume":"21","author":"Goff","year":"2021","journal-title":"Clin. Breast Cancer"},{"key":"2024112311062171800_bib21","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.devcel.2017.10.001","article-title":"Skin and its regenerative powers: an alliance between stem cells and their niche","volume":"43","author":"Gonzales","year":"2017","journal-title":"Dev. Cell"},{"key":"2024112311062171800_bib22","first-page":"1997","article-title":"ERK\/MAPK signalling pathway and tumorigenesis","volume":"19","author":"Guo","year":"2020","journal-title":"Exp. Ther. Med."},{"key":"2024112311062171800_bib23","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.neuron.2015.01.026","article-title":"Neural regulation of hematopoiesis, inflammation, and cancer","volume":"86","author":"Hanoun","year":"2015","journal-title":"Neuron"},{"key":"2024112311062171800_bib24","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1161\/CIRCRESAHA.111.240226","article-title":"Ablation of the leptin receptor in the hypothalamic arcuate nucleus abrogates leptin-induced sympathetic activation","volume":"108","author":"Harlan","year":"2011","journal-title":"Circ. Res."},{"key":"2024112311062171800_bib25","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nm.3589","article-title":"Chronic variable stress activates hematopoietic stem cells","volume":"20","author":"Heidt","year":"2014","journal-title":"Nat. Med."},{"key":"2024112311062171800_bib26","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1186\/s13287-021-02527-y","article-title":"A systematic summary of survival and death signalling during the life of hair follicle stem cells","volume":"12","author":"Hu","year":"2021","journal-title":"Stem Cell Res. Ther."},{"key":"2024112311062171800_bib27","first-page":"983","article-title":"Mammary epithelial tubes elongate through MAPK-dependent coordination of cell migration","volume":"143","author":"Huebner","year":"2016","journal-title":"Development"},{"key":"2024112311062171800_bib28","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1242\/dev.087643","article-title":"Mammary gland development: cell fate specification, stem cells and the microenvironment","volume":"142","author":"Inman","year":"2015","journal-title":"Development"},{"key":"2024112311062171800_bib29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/j.1748-1716.1994.tb09701.x","article-title":"Haemorrhage-induced splenic vasodilation in the rat is mediated by sympathetic vasomotor nerves","volume":"150","author":"Iversen","year":"1994","journal-title":"Acta Physiol. Scand."},{"key":"2024112311062171800_bib30","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1038\/s41593-019-0430-3","article-title":"Genetic manipulation of autonomic nerve fiber innervation and activity and its effect on breast cancer progression","volume":"22","author":"Kamiya","year":"2019","journal-title":"Nat. Neurosci."},{"key":"2024112311062171800_bib31","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1088\/1361-6579\/aa6782","article-title":"An introduction into autonomic nervous function","volume":"38","author":"Karemaker","year":"2017","journal-title":"Physiol. Meas."},{"key":"2024112311062171800_bib32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.cell.2005.10.041","article-title":"Signals from the sympathetic nervous system regulate hematopoietic stem cell egress from bone marrow","volume":"124","author":"Katayama","year":"2006","journal-title":"Cell"},{"key":"2024112311062171800_bib33","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1159\/000065594","article-title":"The role of the autonomic nervous system in liver regeneration and apoptosis\u2014recent developments","volume":"66","author":"Kiba","year":"2002","journal-title":"Digestion"},{"key":"2024112311062171800_bib34","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.3390\/cells11182923","article-title":"Macrophage-secreted CSF1 transmits a calorie restriction-induced self-renewal signal to mammary epithelial stem cells","volume":"11","author":"Kosenko","year":"2022","journal-title":"Cells"},{"key":"2024112311062171800_bib35","first-page":"199","article-title":"Pharmacological actions of 6-hydroxydopamine","volume":"26","author":"Kostrzewa","year":"1974","journal-title":"Pharmacol. Rev."},{"key":"2024112311062171800_bib36","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.ydbio.2010.06.019","article-title":"Morphogenesis of the developing mammary gland: stage-dependent impact of adipocytes","volume":"344","author":"Landskroner-Eiger","year":"2010","journal-title":"Dev. Biol."},{"key":"2024112311062171800_bib37","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1091\/mbc.e12-01-0060","article-title":"The Ras-like protein R-Ras2\/TC21 is important for proper mammary gland development","volume":"23","author":"Larive","year":"2012","journal-title":"Mol. Biol. Cell"},{"key":"2024112311062171800_bib38","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.3390\/cells11152310","article-title":"Importance of the microenvironment and mechanosensing in adipose tissue biology","volume":"11","author":"Lecoutre","year":"2022","journal-title":"Cells"},{"key":"2024112311062171800_bib39","doi-asserted-by":"crossref","first-page":"110548","DOI":"10.1016\/j.celrep.2022.110548","article-title":"Procr functions as a signaling receptor and is essential for the maintenance and self-renewal of mammary stem cells","volume":"38","author":"Liu","year":"2022","journal-title":"Cell Rep."},{"key":"2024112311062171800_bib40","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0165-5728(85)90031-1","article-title":"Involvement of peripheral and central catecholamine systems in neural\u2013immune interactions","volume":"10","author":"Livnat","year":"1985","journal-title":"J. Neuroimmunol."},{"key":"2024112311062171800_bib41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1098\/rspb.1958.0071","article-title":"Hormonal synergism in mammary growth","volume":"149","author":"Lyons","year":"1958","journal-title":"Proc. R. Soc. Lond. B"},{"key":"2024112311062171800_bib43","first-page":"e4389","article-title":"Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification","author":"McLean","year":"2012","journal-title":"J. Vis. Exp."},{"key":"2024112311062171800_bib42","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.trsl.2014.01.005","article-title":"Liver regeneration","volume":"163","author":"Mao","year":"2014","journal-title":"Transl. Res."},{"key":"2024112311062171800_bib44","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1073\/pnas.0401376101","article-title":"Stromal fibroblasts influence human mammary epithelial cell morphogenesis","volume":"101","author":"Medina","year":"2004","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2024112311062171800_bib45","first-page":"1039","article-title":"Endocrine control of mammary gland development and function in the C3H\/He Crgl mouse","volume":"21","author":"Nandi","year":"1958","journal-title":"J. Natl Cancer Inst."},{"key":"2024112311062171800_bib46","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1590\/S1516-31801994000200004","article-title":"Morphological and ultrastructural aspects of the cyclical changes of human mammary gland during the menstrual cycle","volume":"112","author":"Nazario","year":"1994","journal-title":"Sao Paulo Med. J."},{"key":"2024112311062171800_bib47","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s10911-014-9324-x","article-title":"Hormonal regulation of the immune microenvironment in the mammary gland","volume":"19","author":"Need","year":"2014","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"2024112311062171800_bib48","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1476-5381.2011.01791.x","article-title":"Involvement of \u03b12- and \u03b22-adrenoceptors on breast cancer cell proliferation and tumour growth regulation","volume":"166","author":"Perez Pinero","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"2024112311062171800_bib49","doi-asserted-by":"crossref","first-page":"a003244","DOI":"10.1101\/cshperspect.a003244","article-title":"The role of the microenvironment in mammary gland development and cancer","volume":"2","author":"Polyak","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2024112311062171800_bib50","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1096\/fj.15-277798","article-title":"The \u03b22-adrenoceptor activates a positive cAMP\u2013calcium feedforward loop to drive breast cancer cell invasion","volume":"30","author":"Pon","year":"2016","journal-title":"FASEB J."},{"key":"2024112311062171800_bib51","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/ncb3025","article-title":"Mammary stem cells have myoepithelial cell properties","volume":"16","author":"Prater","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"2024112311062171800_bib52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41574-018-0126-x","article-title":"The obese adipose tissue microenvironment in cancer development and progression","volume":"15","author":"Quail","year":"2019","journal-title":"Nat. Rev. Endocrinol."},{"key":"2024112311062171800_bib53","doi-asserted-by":"crossref","first-page":"a013458","DOI":"10.1101\/cshperspect.a013458","article-title":"On the role of the microenvironment in mammary gland development and cancer","volume":"4","author":"Radisky","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"2024112311062171800_bib54","doi-asserted-by":"crossref","first-page":"5894347","DOI":"10.1155\/2016\/5894347","article-title":"Macrophages and neutrophils: regulation of the inflammatory microenvironment in autoimmunity and cancer","volume":"2016","author":"Rahat","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"2024112311062171800_bib55","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/j.devcel.2021.06.016","article-title":"Microenvironmental control of cell fate decisions in mammary gland development and cancer","volume":"56","author":"Rauner","year":"2021","journal-title":"Dev. Cell"},{"key":"2024112311062171800_bib56","first-page":"231","article-title":"A catechol derivative (4-methylcatechol) accelerates the recovery from experimental acrylamide-induced neuropathy","volume":"276","author":"Saita","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2024112311062171800_bib57","doi-asserted-by":"crossref","first-page":"14094","DOI":"10.1074\/jbc.M611370200","article-title":"Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation","volume":"282","author":"Sastry","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2024112311062171800_bib58","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/nature04372","article-title":"Generation of a functional mammary gland from a single stem cell","volume":"439","author":"Shackleton","year":"2006","journal-title":"Nature"},{"key":"2024112311062171800_bib59","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.cell.2020.06.031","article-title":"Cell types promoting goosebumps form a niche to regulate hair follicle stem cells","volume":"182","author":"Shwartz","year":"2020","journal-title":"Cell"},{"key":"2024112311062171800_bib60","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature23642","article-title":"Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis","volume":"548","author":"Sigal","year":"2017","journal-title":"Nature"},{"key":"2024112311062171800_bib61","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1432-0436.2006.00105.x","article-title":"Hormonal and local control of mammary branching morphogenesis","volume":"74","author":"Sternlicht","year":"2006","journal-title":"Differentiation"},{"key":"2024112311062171800_bib62","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nature04496","article-title":"Purification and unique properties of mammary epithelial stem cells","volume":"439","author":"Stingl","year":"2006","journal-title":"Nature"},{"key":"2024112311062171800_bib63","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0092-8674(02)01049-8","article-title":"Leptin regulates bone formation via the sympathetic nervous system","volume":"111","author":"Takeda","year":"2002","journal-title":"Cell"},{"key":"2024112311062171800_bib64","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nature10573","article-title":"Distinct stem cells contribute to mammary gland development and maintenance","volume":"479","author":"Van Keymeulen","year":"2011","journal-title":"Nature"},{"key":"2024112311062171800_bib65","doi-asserted-by":"crossref","first-page":"2563","DOI":"10.1101\/gad.1849509","article-title":"Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis","volume":"23","author":"Visvader","year":"2009","journal-title":"Genes Dev."},{"key":"2024112311062171800_bib66","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.stem.2012.02.018","article-title":"The stem cell niche in regenerative medicine","volume":"10","author":"Wagers","year":"2012","journal-title":"Cell Stem Cell"},{"key":"2024112311062171800_bib67","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nature13851","article-title":"Identification of multipotent mammary stem cells by protein C receptor expression","volume":"517","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"2024112311062171800_bib68","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/s41586-020-2527-y","article-title":"A leptin\u2013BDNF pathway regulating sympathetic innervation of adipose tissue","volume":"583","author":"Wang","year":"2020","journal-title":"Nature"},{"key":"2024112311062171800_bib69","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.3390\/ijms23031464","article-title":"MAPK\/ERK pathway as a central regulator in vertebrate organ regeneration","volume":"23","author":"Wen","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2024112311062171800_bib70","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1126\/science.1067431","article-title":"Stromal effects on mammary gland development and breast cancer","volume":"296","author":"Wiseman","year":"2002","journal-title":"Science"},{"key":"2024112311062171800_bib71","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/s41586-019-1156-9","article-title":"Innervation of thermogenic adipose tissue via a calsyntenin 3\u03b2\u2013S100b axis","volume":"569","author":"Zeng","year":"2019","journal-title":"Nature"},{"key":"2024112311062171800_bib72","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41586-020-1935-3","article-title":"Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells","volume":"577","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"2024112311062171800_bib73","doi-asserted-by":"crossref","first-page":"830","DOI":"10.4143\/crt.2019.510","article-title":"Activation of \u03b22-adrenergic receptor promotes growth and angiogenesis in breast cancer by down-regulating PPAR\u03b3","volume":"52","author":"Zhou","year":"2020","journal-title":"Cancer Res. Treat."},{"key":"2024112311062171800_bib74","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41536-023-00296-1","article-title":"Macrophages maintain mammary stem cell activity and mammary homeostasis via TNF-\u03b1\u2013PI3K\u2013Cdk1\/Cyclin B1 axis","volume":"8","author":"Zhou","year":"2023","journal-title":"NPJ Regen. Med."}],"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjae020\/57572900\/mjae020.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/article-pdf\/16\/5\/mjae020\/60795021\/mjae020.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/article-pdf\/16\/5\/mjae020\/60795021\/mjae020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T11:07:02Z","timestamp":1732360022000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/article\/doi\/10.1093\/jmcb\/mjae020\/7671141"}},"subtitle":[],"editor":[{"given":"Zhen-Ge","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":74,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10,21]]}},"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mjae020","relation":{},"ISSN":["1674-2788","1759-4685"],"issn-type":[{"value":"1674-2788","type":"print"},{"value":"1759-4685","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5]]},"published":{"date-parts":[[2024,5]]},"article-number":"mjae020"}}