{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T13:40:23Z","timestamp":1767966023942,"version":"3.49.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32022018"],"award-info":[{"award-number":["32022018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32370780"],"award-info":[{"award-number":["32370780"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1101001"],"award-info":[{"award-number":["2021YFA1101001"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P40 OD010440"],"award-info":[{"award-number":["P40 OD010440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cohesin is a ring complex closed with structural maintenance of chromosome 1 (SMC-1), SMC-3, and a kleisin subunit, mediating sister chromatid cohesion in mitosis and meiosis. Kleisin N- and C-terminal domains interact with SMC-3 and SMC-1, forming two distinct cohesin gates. Whether these gates are specialized for mitosis and meiosis remains elusive. Here, we create Caenorhabditis elegans mutants that express chimeric proteins swapping N- and C-terminal domains between different kleisins to investigate how these gates are specialized for different cell division programs. Replacing the meiotic REC-8\u00a0N-terminus with that of a cell division-unrelated kleisin COH-1 or the mitotic kleisin sister chromatid cohesion protein 1 (SCC-1) disrupts inter-sister chromatid cohesion and causes severe meiotic defects. Swapping the REC-8 C-terminus with that of COH-1 or SCC-1 largely retains the meiotic functions of REC-8 but causes age-related chromosome abnormalities. A specialized C-terminus is also required for the functions of SCC-1. Furthermore, point mutations in the REC-8 C-terminus cause severe meiotic defects without impairing the SMC-1\u2013kleisin interaction, suggesting an integrated SMC-1\u2013kleisin gate. These findings suggest the requirements for specialized cohesin gates in different biological processes.<\/jats:p>","DOI":"10.1093\/jmcb\/mjae047","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T02:49:41Z","timestamp":1728960581000},"source":"Crossref","is-referenced-by-count":3,"title":["Cohesin ring gates are specialized for meiotic cell division"],"prefix":"10.1093","volume":"16","author":[{"given":"Yuanyuan","family":"Liu","sequence":"first","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohan","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruirui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zixuan","family":"Zhu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University Department of Genetics and Cell Biology, , Tianjin 300071 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijie","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinghao","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feifei","family":"Qi","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruoxi","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Zhao","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3131-7804","authenticated-orcid":false,"given":"Jun","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]},{"name":"State Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University Department of Genetics and Cell Biology, , Tianjin 300071 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5894-6515","authenticated-orcid":false,"given":"Jinmin","family":"Gao","sequence":"additional","affiliation":[{"name":"Center for Cell Structure and Function, College of Life Sciences, Key Laboratory of Animal Resistance Biology of Shandong Province, Shandong Normal University , Jinan 250014 ,","place":["China"]},{"name":"State Key Laboratory of Medicinal Chemical Biology, Haihe Laboratory of Cell Ecosystem, College of Life Sciences, Nankai University Department of Genetics and Cell Biology, , Tianjin 300071 ,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"2025052712054513400_bib1","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.cub.2003.10.036","article-title":"ATP hydrolysis is required for cohesin's association with chromosomes","volume":"13","author":"Arumugam","year":"2003","journal-title":"Curr. Biol."},{"key":"2025052712054513400_bib2","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.cub.2006.09.002","article-title":"Cohesin's ATPase activity is stimulated by the C-terminal Winged-Helix domain of its kleisin subunit","volume":"16","author":"Arumugam","year":"2006","journal-title":"Curr. Biol."},{"key":"2025052712054513400_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cub.2017.12.020","article-title":"SMC1\u03b1 substitutes for many meiotic functions of SMC1\u03b2 but cannot protect telomeres from damage","volume":"28","author":"Biswas","year":"2018","journal-title":"Curr. Biol."},{"key":"2025052712054513400_bib4","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.celrep.2016.09.059","article-title":"Cohesin removal along the chromosome arms during the first meiotic division depends on a NEK1\u2013PP1\u03b3\u2013WAPL axis in the mouse","volume":"17","author":"Brieno-Enriquez","year":"2016","journal-title":"Cell Rep."},{"key":"2025052712054513400_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(00)00131-8","article-title":"Disjunction of homologous chromosomes in meiosis I depends on proteolytic cleavage of the meiotic cohesin Rec8 by separin","volume":"103","author":"Buonomo","year":"2000","journal-title":"Cell"},{"key":"2025052712054513400_bib6","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.cub.2015.12.073","article-title":"Chromosome cohesion established by Rec8\u2013cohesin in fetal oocytes is maintained without detectable turnover in oocytes arrested for months in mice","volume":"26","author":"Burkhardt","year":"2016","journal-title":"Curr. Biol."},{"key":"2025052712054513400_bib7","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1534\/genetics.119.302625","article-title":"Synaptonemal complex central region proteins promote localization of pro-crossover factors to recombination events during Caenorhabditis elegans meiosis","volume":"213","author":"Cahoon","year":"2019","journal-title":"Genetics"},{"key":"2025052712054513400_bib8","doi-asserted-by":"crossref","first-page":"9732","DOI":"10.1073\/pnas.1807213115","article-title":"Intermediate step of cohesin's ATPase cycle allows cohesin to entrap DNA","volume":"115","author":"\u00c7amdere","year":"2018","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025052712054513400_bib9","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1093\/nar\/gkw034","article-title":"Rad61\/Wpl1 (Wapl), a cohesin regulator, controls chromosome compaction during meiosis","volume":"44","author":"Challa","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"2025052712054513400_bib10","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.cub.2010.06.069","article-title":"Evidence that weakened centromere cohesion is a leading cause of age-related aneuploidy in oocytes","volume":"20","author":"Chiang","year":"2010","journal-title":"Curr. Biol."},{"key":"2025052712054513400_bib11","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1091\/mbc.e12-11-0841","article-title":"akirin is required for diakinesis bivalent structure and synaptonemal complex disassembly at meiotic prophase I","volume":"24","author":"Clemons","year":"2013","journal-title":"Mol. Biol. Cell"},{"key":"2025052712054513400_bib12","doi-asserted-by":"crossref","first-page":"e10851","DOI":"10.7554\/eLife.10851","article-title":"Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes","volume":"5","author":"Crawley","year":"2016","journal-title":"eLife"},{"key":"2025052712054513400_bib13","doi-asserted-by":"crossref","first-page":"e1004497","DOI":"10.1371\/journal.pgen.1004497","article-title":"Arabidopsis thaliana WAPL is essential for the prophase removal of cohesin during meiosis","volume":"10","author":"De","year":"2014","journal-title":"PLoS Genet."},{"key":"2025052712054513400_bib14","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1111\/j.1474-9726.2012.00866.x","article-title":"Chromosome cohesion decreases in human eggs with advanced maternal age","volume":"11","author":"Duncan","year":"2012","journal-title":"Aging Cell"},{"key":"2025052712054513400_bib15","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.molcel.2016.01.025","article-title":"Cohesin releases DNA through asymmetric ATPase-driven ring opening","volume":"61","author":"Elbatsh","year":"2016","journal-title":"Mol. Cell"},{"key":"2025052712054513400_bib17","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1256917","article-title":"Closing the cohesin ring: structure and function of its Smc3\u2013kleisin interface","volume":"346","author":"Gligoris","year":"2014","journal-title":"Science"},{"key":"2025052712054513400_bib18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.devcel.2007.11.016","article-title":"HTP-3 links DSB formation with homolog pairing and crossing over during C. elegans meiosis","volume":"14","author":"Goodyer","year":"2008","journal-title":"Dev. Cell"},{"key":"2025052712054513400_bib19","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.cub.2016.05.006","article-title":"Dynamic and stable cohesins regulate synaptonemal complex assembly and chromosome segregation","volume":"26","author":"Gyuricza","year":"2016","journal-title":"Curr. Biol."},{"key":"2025052712054513400_bib20","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.devcel.2014.09.010","article-title":"Cohesin and its regulation: on the logic of X-shaped chromosomes","volume":"31","author":"Haarhuis","year":"2014","journal-title":"Dev. Cell"},{"key":"2025052712054513400_bib21","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.molcel.2004.08.030","article-title":"Structure and stability of cohesin's Smc1\u2013kleisin interaction","volume":"15","author":"Haering","year":"2004","journal-title":"Mol. Cell"},{"key":"2025052712054513400_bib22","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1016\/j.molcel.2020.07.013","article-title":"A structure-based mechanism for DNA entry into the cohesin ring","volume":"79","author":"Higashi","year":"2020","journal-title":"Mol. Cell"},{"key":"2025052712054513400_bib23","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/ng1672","article-title":"SMC1\u03b2-deficient female mice provide evidence that cohesins are a missing link in age-related nondisjunction","volume":"37","author":"Hodges","year":"2005","journal-title":"Nat. Genet."},{"key":"2025052712054513400_bib24","doi-asserted-by":"crossref","first-page":"e3000635","DOI":"10.1371\/journal.pbio.3000635","article-title":"Evolutionary repair: changes in multiple functional modules allow meiotic cohesin to support mitosis","volume":"18","author":"Hsieh","year":"2020","journal-title":"PLoS Biol."},{"key":"2025052712054513400_bib25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/gtc.12652","article-title":"The cohesin complex in mammalian meiosis","volume":"24","author":"Ishiguro","year":"2019","journal-title":"Genes Cells"},{"key":"2025052712054513400_bib26","doi-asserted-by":"crossref","first-page":"e38356","DOI":"10.7554\/eLife.38356","article-title":"Structural basis for Scc3-dependent cohesin recruitment to chromatin","volume":"7","author":"Li","year":"2018","journal-title":"eLife"},{"key":"2025052712054513400_bib27","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.cub.2010.08.023","article-title":"Age-related meiotic segregation errors in mammalian oocytes are preceded by depletion of cohesin and Sgo2","volume":"20","author":"Lister","year":"2010","journal-title":"Curr. Biol."},{"key":"2025052712054513400_bib28","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ncb2637","article-title":"Phosphorylation-enabled binding of SGO1\u2013PP2A to cohesin protects sororin and centromeric cohesion during mitosis","volume":"15","author":"Liu","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"2025052712054513400_bib29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jgg.2022.07.002","article-title":"Reproductive aging: biological pathways and potential interventive strategies","volume":"50","author":"Liu","year":"2023","journal-title":"J. Genet. Genomics"},{"key":"2025052712054513400_bib30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41592-022-01488-1","article-title":"ColabFold: making protein folding accessible to all","volume":"19","author":"Mirdita","year":"2022","journal-title":"Nat. Methods"},{"key":"2025052712054513400_bib31","doi-asserted-by":"crossref","first-page":"2399","DOI":"10.1091\/mbc.e02-09-0603","article-title":"Distinct developmental function of two Caenorhabditis elegans homologs of the cohesin subunit Scc1\/Rad21","volume":"14","author":"Mito","year":"2003","journal-title":"Mol. Biol. Cell"},{"key":"2025052712054513400_bib32","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41594-020-0379-7","article-title":"The structure of the cohesin ATPase elucidates the mechanism of SMC\u2013kleisin ring opening","volume":"27","author":"Muir","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"2025052712054513400_bib33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature12867","article-title":"Biochemical reconstitution of topological DNA binding by the cohesin ring","volume":"505","author":"Murayama","year":"2014","journal-title":"Nature"},{"key":"2025052712054513400_bib34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.cell.2010.10.031","article-title":"Sororin mediates sister chromatid cohesion by antagonizing Wapl","volume":"143","author":"Nishiyama","year":"2010","journal-title":"Cell"},{"key":"2025052712054513400_bib35","doi-asserted-by":"crossref","first-page":"13404","DOI":"10.1073\/pnas.1305020110","article-title":"Aurora B and Cdk1 mediate wapl activation and release of acetylated cohesin from chromosomes by phosphorylating sororin","volume":"110","author":"Nishiyama","year":"2013","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2025052712054513400_bib36","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1101\/gad.192701","article-title":"A Caenorhabditis elegans cohesion protein with functions in meiotic chromosome pairing and disjunction","volume":"15","author":"Pasierbek","year":"2001","journal-title":"Genes Dev."},{"key":"2025052712054513400_bib37","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.1111\/febs.13301","article-title":"Complex elaboration: making sense of meiotic cohesin dynamics","volume":"282","author":"Rankin","year":"2015","journal-title":"FEBS J."},{"key":"2025052712054513400_bib38","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1038\/ncb1135","article-title":"Cohesin SMC1\u03b2 is required for meiotic chromosome dynamics, sister chromatid cohesion and DNA recombination","volume":"6","author":"Revenkova","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"2025052712054513400_bib39","doi-asserted-by":"crossref","first-page":"7550","DOI":"10.1038\/ncomms8550","article-title":"Bivalent separation into univalents precedes age-related meiosis I errors in oocytes","volume":"6","author":"Sakakibara","year":"2015","journal-title":"Nat. Commun."},{"key":"2025052712054513400_bib40","doi-asserted-by":"crossref","first-page":"e03467","DOI":"10.7554\/eLife.03467","article-title":"Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes","volume":"3","author":"Severson","year":"2014","journal-title":"eLife"},{"key":"2025052712054513400_bib41","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1126\/science.abb0981","article-title":"Cryo-EM structure of the human cohesin\u2013NIPBL\u2013DNA complex","volume":"368","author":"Shi","year":"2020","journal-title":"Science"},{"key":"2025052712054513400_bib42","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1101\/gad.1844309","article-title":"Releasing cohesin from chromosome arms in early mitosis: opposing actions of Wapl\u2013Pds5 and Sgo1","volume":"23","author":"Shintomi","year":"2009","journal-title":"Genes Dev."},{"key":"2025052712054513400_bib43","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1101\/gad.605910","article-title":"Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes","volume":"24","author":"Tachibana-Konwalski","year":"2010","journal-title":"Genes Dev."},{"key":"2025052712054513400_bib44","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0092-8674(00)00217-8","article-title":"Functional genomics identifies monopolin: a kinetochore protein required for segregation of homologs during meiosis I","volume":"103","author":"Toth","year":"2000","journal-title":"Cell"},{"key":"2025052712054513400_bib45","doi-asserted-by":"crossref","first-page":"e202212035","DOI":"10.1083\/jcb.202212035","article-title":"The dynamic recruitment of LAB proteins senses meiotic chromosome axis differentiation in C. elegans","volume":"223","author":"Wang","year":"2024","journal-title":"J. Cell Biol."},{"key":"2025052712054513400_bib46","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.molcel.2018.07.006","article-title":"In vivo evidence for ATPase-dependent DNA translocation by the Bacillus subtilis SMC condensin complex","volume":"71","author":"Wang","year":"2018","journal-title":"Mol. Cell"},{"key":"2025052712054513400_bib47","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tcb.2016.09.002","article-title":"Mechanisms of aneuploidy in human eggs","volume":"27","author":"Webster","year":"2017","journal-title":"Trends Cell Biol."},{"key":"2025052712054513400_bib48","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1016\/j.cub.2003.10.030","article-title":"A model for ATP hydrolysis-dependent binding of cohesin to DNA","volume":"13","author":"Weitzer","year":"2003","journal-title":"Curr. Biol."},{"key":"2025052712054513400_bib49","doi-asserted-by":"crossref","first-page":"e3000817","DOI":"10.1371\/journal.pbio.3000817","article-title":"Quantitative cytogenetics reveals molecular stoichiometry and longitudinal organization of meiotic chromosome axes and loops","volume":"18","author":"Woglar","year":"2020","journal-title":"PLoS Biol."},{"key":"2025052712054513400_bib50","doi-asserted-by":"crossref","first-page":"e201910086","DOI":"10.1083\/jcb.201910086","article-title":"Multivalent weak interactions between assembly units drive synaptonemal complex formation","volume":"219","author":"Zhang","year":"2020","journal-title":"J. Cell Biol."},{"key":"2025052712054513400_bib51","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1016\/j.cub.2019.09.006","article-title":"Meiotic kinetochores fragment into multiple lobes upon cohesin loss in aging eggs","volume":"29","author":"Zielinska","year":"2019","journal-title":"Curr. Biol."},{"key":"2025052712054513400_bib52","doi-asserted-by":"crossref","first-page":"e11389","DOI":"10.7554\/eLife.11389","article-title":"Sister kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect","volume":"4","author":"Zielinska","year":"2015","journal-title":"eLife"}],"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjae047\/59751491\/mjae047.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/article-pdf\/16\/10\/mjae047\/59751491\/mjae047.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/article-pdf\/16\/10\/mjae047\/59751491\/mjae047.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T16:06:00Z","timestamp":1748361960000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/article\/doi\/10.1093\/jmcb\/mjae047\/7821670"}},"subtitle":[],"editor":[{"given":"Xuebiao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":51,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,5,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mjae047","relation":{},"ISSN":["1674-2788","1759-4685"],"issn-type":[{"value":"1674-2788","type":"print"},{"value":"1759-4685","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,10]]},"article-number":"mjae047"}}