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It represents a potential candidate gene linked to the susceptibility of type 2 diabetes, and decreased RBM38 expression can enhance the proliferation of pancreatic cancer cells in humans. However, its role in pancreatic development remains elusive. In this study, we explored the function of Rbm38 using zebrafish as a model. Pancreatic expression of Rbm38 is present at larval stages and is controlled by several transcription factors acting on specific rbm38 promoter regions. The loss of Rbm38 leads to abnormal pancreatic enlargement. Mechanistically, Rbm38 is involved in several aspects of post-transcriptional regulation of pancreatic gene expression. It destabilizes pdx1 transcripts by binding to the 3\u2032-untranslated region and regulates alternative splicing of key pancreatic transcription factor genes, including isl1a, smad2, and nkx2.2a. These findings elucidate the role of Rbm38 in pancreatic development and highlight its significance in maintaining pancreatic homeostasis.<\/jats:p>","DOI":"10.1093\/jmcb\/mjaf025","type":"journal-article","created":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T11:37:08Z","timestamp":1754998628000},"source":"Crossref","is-referenced-by-count":1,"title":["RNA-binding protein Rbm38 as a multifaceted post-transcriptional regulator in zebrafish pancreatic development"],"prefix":"10.1093","volume":"17","author":[{"given":"Xiangmin","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Marine Life Sciences, Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China , Qingdao 266003 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianpeng","family":"Li","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences, Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China , Qingdao 266003 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences, Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China , Qingdao 266003 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences, Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China , Qingdao 266003 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunchao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences, Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China , Qingdao 266003 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences, Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China , Qingdao 266003 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuaiqi","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences, Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China , Qingdao 266003 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Marine Life Sciences, Key Laboratory of Evolution & Marine Biodiversity (Ministry of Education) and Institute of Evolution & Marine Biodiversity, Ocean University of China , Qingdao 266003 ,","place":["China"]},{"name":"Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center , Qingdao 266003 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,8,12]]},"reference":[{"key":"2026020310565391600_bib1","doi-asserted-by":"crossref","first-page":"4595","DOI":"10.1038\/ncomms5595","article-title":"Backbone-independent nucleic acid binding by splicing factor SUP-12 reveals key aspects of molecular recognition","volume":"5","author":"Amrane","year":"2014","journal-title":"Nat. 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