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Here, by utilizing single-cell RNA sequencing, single-nucleus RNA sequencing, SpaTial enhanced resolution omics-sequencing, and UTUC immunofluorescence chip cohort to construct the first comprehensive microenvironmental atlas of CAFs, we investigated the roles of CAFs in UTUC progression. Through hierarchical clustering and the copy number variation scores of UTUC epithelial cells, we classified tumor epithelial cells into high-malignant, medium-malignant, and low-malignant potential categories. We found pronounced interaction signals between different CAF subclusters and all three types of epithelial cells, among which high-malignant epithelial cells exhibited the most significant communication signals with the myofibroblastic CAFs1 (myCAFs1) and myCAFs2 subclusters, and FN1 and COL1A1 generated by CAFs played critical roles in this process, suggesting that the progression of UTUC may be attributed to the activation of tumor cells by CAFs. Additionally, both myCAFs1 and myCAFs2 simultaneously affect bladder urothelial carcinoma (BUC) prognosis, with the risk model showing good consistency across cohorts. Therefore, this study constructs a multi-omics landscape of UTUC and identifies common prognostic markers shared with BUC.<\/jats:p>","DOI":"10.1093\/jmcb\/mjaf032","type":"journal-article","created":{"date-parts":[[2025,9,18]],"date-time":"2025-09-18T11:53:00Z","timestamp":1758196380000},"source":"Crossref","is-referenced-by-count":2,"title":["The tumor-associated fibroblasts regulate urothelial carcinoma progression"],"prefix":"10.1093","volume":"17","author":[{"given":"Yu","family":"Xiao","sequence":"first","affiliation":[{"name":"Kunming University of Science and Technology The Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People\u2019s Hospital of Yunnan Province\/The Affiliated Hospital Department of Urology, , Kunming 650032 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Mechanisms and Intervention Research on High Altitude Disease of Tibet Autonomous region, Key Laboratory of High-Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xizang Minzu University , Xianyang 712082 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Huang","sequence":"additional","affiliation":[{"name":"Kunming University of Science and Technology The Academy for Cell and Life Health, Faculty of Life Science and Technology and Medical School, Kunming University of Science and Technology, and The First People\u2019s Hospital of Yunnan Province\/The Affiliated Hospital Department of Urology, , Kunming 650032 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Yu","sequence":"additional","affiliation":[{"name":"Kunming University of Science and Technology The Academy for Cell and Life Health, Faculty of Life Science and Technology and 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