{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T09:48:41Z","timestamp":1782985721845,"version":"3.54.5"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T00:00:00Z","timestamp":1764633600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32160177"],"award-info":[{"award-number":["32160177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82160292"],"award-info":[{"award-number":["82160292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mitochondria are essential organelles responsible for generating adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS). Despite having their own genome, mitochondria rely on a complex interplay with nuclear-encoded proteins to maintain their function, as mutations in these proteins can lead to mitochondrial dysfunction and associated diseases. Mutations in the SLIRP gene are known to cause severe human mitochondrial diseases, and loss of stem-loop interacting RNA-binding protein (SLIRP) function can impair mitochondrial mRNA stability and translation. However, in vivo roles of the SLIRP protein remain inadequately understood. Drosophila melanogaster serves as a powerful model for studying mitochondrial function, particularly in the context of reproductive system development and gametogenesis. In this study, we focus on the role of the fly Slirp2 in oogenesis. Loss of Slirp2 impairs mitochondrial protein synthesis, leading to reduced OXPHOS efficiency, diminished ATP production, and disrupted insulin\/mTOR signaling. These defects ultimately promote reactive oxygen species-induced programmed cell death, resulting in infertility. Our findings provide novel insights into the mechanistic role of Slirp2 in mitochondrial function and reproductive biology in vivo. We demonstrate that Slirp2 exhibits species-specific regulation of mitochondrial translation, revealing its complex, context-dependent function. These results have broader implications for understanding mitochondrial diseases, suggesting that the effects of Slirp2 mutations may vary across different organisms and tissue types.<\/jats:p>","DOI":"10.1093\/jmcb\/mjaf047","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T13:03:28Z","timestamp":1764680608000},"source":"Crossref","is-referenced-by-count":0,"title":["Slirp2 modulates oogenesis via regulating mitochondrial protein translation"],"prefix":"10.1093","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2990-5691","authenticated-orcid":false,"given":"Jinguo","family":"Cao","sequence":"first","affiliation":[{"name":"Gannan Medical University Key Laboratory of Mitochondrial Medicine, Department of Basic Medicine, , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiting","family":"Zhang","sequence":"additional","affiliation":[{"name":"Gannan Medical University Key Laboratory of Mitochondrial Medicine, Department of Basic Medicine, , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Gannan Medical University Key Laboratory of Mitochondrial Medicine, Department of Basic Medicine, , Ganzhou 341000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Luan","sequence":"additional","affiliation":[{"name":"Cambridge-Suda Genomic Resource Center, Suzhou Medical College, Soochow University , Suzhou 215000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cambridge-Suda Genomic Resource Center, Suzhou Medical College, Soochow University , Suzhou 215000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Huang","sequence":"additional","affiliation":[{"name":"Cambridge-Suda Genomic Resource Center, Suzhou Medical College, Soochow University , Suzhou 215000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingling","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences, Sun Yat-sen University , Guangzhou 510000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Hu","sequence":"additional","affiliation":[{"name":"Gannan Medical University Key Laboratory of Mitochondrial Medicine, Department of Basic Medicine, , Ganzhou 341000 ,","place":["China"]},{"name":"Cambridge-Suda Genomic Resource Center, Suzhou Medical College, Soochow University , Suzhou 215000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,2]]},"reference":[{"key":"2026070205414608300_bib1","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/290457a0","article-title":"Sequence and organization of the human mitochondrial genome","volume":"290","author":"Anderson","year":"1981","journal-title":"Nature"},{"key":"2026070205414608300_bib2","doi-asserted-by":"crossref","first-page":"13920","DOI":"10.1093\/nar\/gku1132","article-title":"Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation","volume":"42","author":"Baggio","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"2026070205414608300_bib3","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/cdd.2010.157","article-title":"Autophagy in Drosophila ovaries is induced by starvation and is required for oogenesis","volume":"18","author":"Barth","year":"2011","journal-title":"Cell Death Differ."},{"key":"2026070205414608300_bib4","doi-asserted-by":"crossref","first-page":"R1082","DOI":"10.1016\/j.cub.2008.09.011","article-title":"Drosophila oogenesis","volume":"18","author":"Bastock","year":"2008","journal-title":"Curr. 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