{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T15:37:50Z","timestamp":1786549070772,"version":"build-2736575974"},"reference-count":105,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T00:00:00Z","timestamp":1767312000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Shanghai Sailing Program","award":["23YF1403900"],"award-info":[{"award-number":["23YF1403900"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82400866"],"award-info":[{"award-number":["82400866"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730017"],"award-info":[{"award-number":["81730017"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["W2411077"],"award-info":[{"award-number":["W2411077"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The parathyroid gland, a pivotal organ regulating calcium and phosphorus homeostasis, harbors two primary cell types: chief cells and the enigmatic oxyphil cells. While scarce in healthy individuals, oxyphil cells undergo pronounced proliferation in uremic secondary hyperparathyroidism (SHPT), and their abundance is strongly associated with resistance to first-line therapies like calcitriol and calcimimetics. This correlation underscores a critical clinical challenge, yet the origin, functional role, and mechanisms driving oxyphil cell proliferation have remained poorly understood. Integrated multi-omics studies have decisively illuminated the underlying mechanisms, revealing uremic milieu-driven transdifferentiation from chief cells to oxyphil cells and the pivotal role of mitochondrial biogenesis activation in this process. This paradigm shift redefines oxyphil cells from passive entities to metabolically hyperactive, autonomous units capable of heightening parathyroid hormone synthesis and secretion. The core mechanism of therapy resistance is explained by the profound downregulation of key regulatory receptors, rendering them insensitive to conventional drugs. This review synthesizes current knowledge and, more importantly, highlights how integrated multi-omics approaches are illuminating the pathobiology of oxyphil cells, providing groundbreaking insights into their function, origin, and proliferation mechanisms. We conclude that these advances are pivotal for developing novel therapeutic strategies to overcome treatment resistance in uremic SHPT.<\/jats:p>","DOI":"10.1093\/jmcb\/mjaf061","type":"journal-article","created":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T12:48:13Z","timestamp":1767271693000},"source":"Crossref","is-referenced-by-count":1,"title":["Unraveling the mystery of parathyroid oxyphil cells in uremic SHPT: ongoing challenges and multi-omics advances"],"prefix":"10.1093","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9371-6192","authenticated-orcid":false,"given":"Jianping","family":"Mao","sequence":"first","affiliation":[{"name":"Division of Nephrology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]},{"name":"National Clinical Research Center for Aging and Medicine, Huashan Hospital, Fudan University , Shanghai 200040 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,1,2]]},"reference":[{"key":"2026081210362131300_bib1","doi-asserted-by":"crossref","first-page":"e13959","DOI":"10.1111\/apha.13959","article-title":"Effects of parathyroid hormone on renal tubular calcium and phosphate handling","volume":"238","author":"Alexander","year":"2023","journal-title":"Acta Physiol."},{"key":"2026081210362131300_bib2","first-page":"421","article-title":"The oxyphil cell in abnormal parathyroid glands. A study of 114 cases","volume":"105","author":"Allen","year":"1981","journal-title":"Arch. Pathol. Lab. Med."},{"key":"2026081210362131300_bib3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/ar.1090830106","article-title":"A study of the parathyroid glands of the normal and hypophysectomized monkey (Macaca mulatta)","volume":"83","author":"Baker","year":"1942","journal-title":"Anat. Rec."},{"key":"2026081210362131300_bib4","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.kint.2017.06.024","article-title":"The function of the parathyroid oxyphil cells in uremia: still a mystery?","volume":"92","author":"Basile","year":"2017","journal-title":"Kidney Int."},{"key":"2026081210362131300_bib5","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1056\/NEJMoa031633","article-title":"Cinacalcet for secondary hyperparathyroidism in patients receiving hemodialysis","volume":"350","author":"Block","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"2026081210362131300_bib6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/BF00218492","article-title":"Occurrence of oxyphil cells in suppressed parathyroid glands","volume":"163","author":"Boquist","year":"1975","journal-title":"Cell Tissue Res."},{"key":"2026081210362131300_bib7","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1053\/j.jrn.2016.07.005","article-title":"Protein-bound uremic toxins from gut microbiota and inflammatory markers in chronic kidney disease","volume":"26","author":"Borges","year":"2016","journal-title":"J. Ren. Nutr."},{"key":"2026081210362131300_bib8","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/joneph\/16.1.116","article-title":"BB genotype of the vitamin D receptor gene polymorphism postpones parathyroidectomy in hemodialysis patients","volume":"16","author":"Borr\u00e0s","year":"2003","journal-title":"J. Nephrol."},{"key":"2026081210362131300_bib9","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1293\/tox.31.1S","article-title":"Nonproliferative and proliferative lesions of the rat and mouse endocrine system","volume":"31","author":"Br\u00e4ndli-Baiocco","year":"2018","journal-title":"J. Toxicol. Pathol."},{"key":"2026081210362131300_bib10","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1681\/ASN.V11101865","article-title":"The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis","volume":"11","author":"Canalejo","year":"2000","journal-title":"J. Am. Soc. Nephrol."},{"key":"2026081210362131300_bib11","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/nature07813","article-title":"AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity","volume":"458","author":"Cant\u00f3","year":"2009","journal-title":"Nature"},{"key":"2026081210362131300_bib12","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1079\/PNS2004335","article-title":"The role of calcium and calcium\/calmodulin-dependent kinases in skeletal muscle plasticity and mitochondrial biogenesis","volume":"63","author":"Chin","year":"2004","journal-title":"Proc. Nutr. Soc."},{"key":"2026081210362131300_bib13","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1136\/jcp.20.4.591","article-title":"The parathyroid oxyphil cells","volume":"20","author":"Christie","year":"1967","journal-title":"J. Clin. Pathol."},{"key":"2026081210362131300_bib14","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/jemt.1070320210","article-title":"Ultrastructure of human parathyroid cells in health and disease","volume":"32","author":"Cinti","year":"1995","journal-title":"Microsc. Res. Tech."},{"key":"2026081210362131300_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1472-6823-7-8","article-title":"Mitochondrial DNA mutations in oxyphilic and chief cell parathyroid adenomas","volume":"7","author":"Costa-Guda","year":"2007","journal-title":"BMC Endocr. Disord."},{"key":"2026081210362131300_bib16","doi-asserted-by":"crossref","first-page":"913","DOI":"10.2215\/CJN.06040710","article-title":"Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options","volume":"6","author":"Cunningham","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2026081210362131300_bib17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s42000-021-00305-2","article-title":"Oxyphil cells in primary hyperparathyroidism: a clinicopathological study","volume":"20","author":"De la Hoz Rodr\u00edguez","year":"2021","journal-title":"Hormones"},{"key":"2026081210362131300_bib18","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1038\/modpathol.2010.132","article-title":"Parathyroid tumors and related disorders","volume":"24","author":"DeLellis","year":"2011","journal-title":"Mod. Pathol."},{"key":"2026081210362131300_bib19","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1007\/s00268-019-04929-9","article-title":"Autofluorescence in parathyroidectomy: signal intensity correlates with serum calcium and parathyroid hormone but routine clinical use is not justified","volume":"43","author":"DiMarco","year":"2019","journal-title":"World J. Surg."},{"key":"2026081210362131300_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s11255-019-02330-y","article-title":"Relationship between parathyroid oxyphil cell proportion and clinical characteristics of patients with chronic kidney disease","volume":"52","author":"Ding","year":"2020","journal-title":"Int. Urol. Nephrol."},{"key":"2026081210362131300_bib21","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0046-8177(82)80293-1","article-title":"The normal parathyroid revisited: percentage of stromal fat","volume":"13","author":"Dufour","year":"1982","journal-title":"Hum. Pathol."},{"key":"2026081210362131300_bib22","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.amjsurg.2007.01.040","article-title":"The positive effect of adenoma weight and oxyphil cell content on preoperative localization with 99mTc-sestamibi scanning for primary hyperparathyroidism","volume":"195","author":"Erbil","year":"2008","journal-title":"Am. J. Surg."},{"key":"2026081210362131300_bib23","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1002\/jcb.25676","article-title":"Cortisol induces reactive oxygen species through a membrane glucocorticoid receptor in rainbow trout myotubes","volume":"118","author":"Espinoza","year":"2017","journal-title":"J. Cell. Biochem."},{"key":"2026081210362131300_bib24","doi-asserted-by":"crossref","first-page":"455","DOI":"10.18410\/jebmh\/2014\/72","article-title":"Age-wise histological changes in adult human parathyroid glands","volume":"1","author":"Fating","year":"2014","journal-title":"J. Evid. Based Med. Healthc."},{"key":"2026081210362131300_bib25","doi-asserted-by":"crossref","first-page":"9757201","DOI":"10.1155\/2019\/9757201","article-title":"Mitochondrial dynamics: biogenesis, fission, fusion, and mitophagy in the regulation of stem cell behaviors","volume":"2019","author":"Fu","year":"2019","journal-title":"Stem Cells Int."},{"key":"2026081210362131300_bib26","doi-asserted-by":"crossref","first-page":"e1001393","DOI":"10.1371\/journal.pgen.1001393","article-title":"Comparative analysis of proteome and transcriptome variation in mouse","volume":"7","author":"Ghazalpour","year":"2011","journal-title":"PLoS Genet."},{"key":"2026081210362131300_bib27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/path.1700480119","article-title":"The normal histology of the parathyroid glands","volume":"48","author":"Gilmour","year":"1939","journal-title":"J. Pathol."},{"key":"2026081210362131300_bib28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.semcdb.2010.01.022","article-title":"The pharyngeal pouches and clefts: development, evolution, structure and derivatives","volume":"21","author":"Grevellec","year":"2010","journal-title":"Semin. Cell Dev. Biol."},{"key":"2026081210362131300_bib29","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1749-6632.2011.06221.x","article-title":"Transcription factors in parathyroid development: lessons from hypoparathyroid disorders","volume":"1237","author":"Grigorieva","year":"2011","journal-title":"Ann. NY Acad. Sci."},{"key":"2026081210362131300_bib30","first-page":"1","article-title":"Anatomy and histopathology of human parathyroid glands","volume":"16","author":"Grimelius","year":"1981","journal-title":"Pathol. Annu."},{"key":"2026081210362131300_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nature14966","article-title":"Single-cell messenger RNA sequencing reveals rare intestinal cell types","volume":"525","author":"Gr\u00fcn","year":"2015","journal-title":"Nature"},{"key":"2026081210362131300_bib32","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.cell.2015.10.039","article-title":"Design and analysis of single-cell sequencing experiments","volume":"163","author":"Gr\u00fcn","year":"2015","journal-title":"Cell"},{"key":"2026081210362131300_bib33","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF03347464","article-title":"Oncocytic mania: a review of oncocytic lesions throughout the body","volume":"34","author":"Guaraldi","year":"2011","journal-title":"J. Endocrinol. Invest."},{"key":"2026081210362131300_bib34","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nmeth.3971","article-title":"Diffusion pseudotime robustly reconstructs lineage branching","volume":"13","author":"Haghverdi","year":"2016","journal-title":"Nat. Methods"},{"key":"2026081210362131300_bib35","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1067\/msy.2001.118371","article-title":"In vitro accumulation of technetium-99m-sestamibi in human parathyroid mitochondria","volume":"130","author":"Hetrakul","year":"2001","journal-title":"Surgery"},{"key":"2026081210362131300_bib36","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1007\/s12022-015-9378-3","article-title":"Oxyphil cell parathyroid adenomas causing primary hyperparathyroidism: a clinico-pathological correlation","volume":"26","author":"Howson","year":"2015","journal-title":"Endocr. Pathol."},{"key":"2026081210362131300_bib37","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.1039\/C3MB70188C","article-title":"Complementary iTRAQ proteomics and RNA-seq transcriptomics reveal multiple levels of regulation in response to nitrogen starvation in Synechocystis sp. PCC 6803","volume":"9","author":"Huang","year":"2013","journal-title":"Mol. Biosyst."},{"key":"2026081210362131300_bib38","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bse0470069","article-title":"Regulation of mitochondrial biogenesis","volume":"47","author":"Jornayvaz","year":"2010","journal-title":"Essays Biochem."},{"key":"2026081210362131300_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12882-017-0457-1","article-title":"Indoxyl sulfate\u2014the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease","volume":"18","author":"Kami\u0144ski","year":"2017","journal-title":"BMC Nephrol."},{"key":"2026081210362131300_bib40","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s40620-018-0530-2","article-title":"NF-\u03baB activation contributes to parathyroid cell proliferation in chronic kidney disease","volume":"31","author":"Kan","year":"2018","journal-title":"J. Nephrol."},{"key":"2026081210362131300_bib41","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/00000478-198106000-00008","article-title":"Surgical pathology of hyperparathyroidism. Usefulness of fat stain and problems in interpretation","volume":"5","author":"Kasdon","year":"1981","journal-title":"Am. J. Surg. Pathol."},{"key":"2026081210362131300_bib42","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1111\/j.1523-1755.2005.00178.x","article-title":"Pretreatment serum FGF-23 levels predict the efficacy of calcitriol therapy in dialysis patients","volume":"67","author":"Kazama","year":"2005","journal-title":"Kidney Int."},{"key":"2026081210362131300_bib43","first-page":"179","article-title":"Expression of parathyroid hormone-related protein (PTHrP) in parathyroid tissue under normal and pathological conditions","volume":"17","author":"Kitazawa","year":"2002","journal-title":"Histol. Histopathol."},{"key":"2026081210362131300_bib44","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.molcel.2015.04.005","article-title":"The technology and biology of single-cell RNA sequencing","volume":"58","author":"Kolodziejczyk","year":"2015","journal-title":"Mol. Cell"},{"key":"2026081210362131300_bib45","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.kisu.2021.11.003","article-title":"Epidemiology of chronic kidney disease: an update 2022","volume":"12","author":"Kovesdy","year":"2022","journal-title":"Kidney Int. Suppl."},{"key":"2026081210362131300_bib46","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jprot.2018.02.029","article-title":"Comparative proteomic analysis of chief and oxyphil cell nodules in refractory uremic hyperparathyroidism by iTRAQ coupled LC\u2013MS\/MS","volume":"179","author":"Li","year":"2018","journal-title":"J. Proteomics"},{"key":"2026081210362131300_bib47","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1681\/ASN.2004060512","article-title":"Cinacalcet HCl, an oral calcimimetic agent for the treatment of secondary hyperparathyroidism in hemodialysis and peritoneal dialysis: a randomized, double-blind, multicenter study","volume":"16","author":"Lindberg","year":"2005","journal-title":"J. Am. Soc. Nephrol."},{"key":"2026081210362131300_bib48","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1093\/joneph\/16.5.716","article-title":"Calcitriol pulse therapy and histology of parathyroid glands in hemodialysis patients","volume":"16","author":"Lomonte","year":"2003","journal-title":"J. Nephrol."},{"key":"2026081210362131300_bib49","doi-asserted-by":"crossref","first-page":"794","DOI":"10.2215\/CJN.04150907","article-title":"Does vitamin D receptor and calcium receptor activation therapy play a role in the histopathologic alterations of parathyroid glands in refractory uremic hyperparathyroidism?","volume":"3","author":"Lomonte","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2026081210362131300_bib50","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.mce.2017.10.001","article-title":"Molecular profiles of oxyphilic and chief cell parathyroid adenoma","volume":"470","author":"Lu","year":"2018","journal-title":"Mol. Cell. Endocrinol."},{"key":"2026081210362131300_bib51","doi-asserted-by":"crossref","first-page":"1165890","DOI":"10.3389\/fendo.2023.1165890","article-title":"Single-cell RNA sequencing reveals the role of cell heterogeneity in the sex difference in primary hyperparathyroidism","volume":"14","author":"Lu","year":"2023","journal-title":"Front. Endocrinol."},{"key":"2026081210362131300_bib52","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3389\/fcell.2020.00467","article-title":"Mitophagy, mitochondrial homeostasis, and cell fate","volume":"8","author":"Ma","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"2026081210362131300_bib53","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1080\/13543784.2024.2369307","article-title":"Secondary hyperparathyroidism in chronic kidney disease: pathophysiology, current treatments and investigational drugs","volume":"33","author":"Magagnoli","year":"2024","journal-title":"Expert Opin. Investig. Drugs"},{"key":"2026081210362131300_bib54","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1681\/ASN.V1261242","article-title":"Parathyroidectomy in patients on renal replacement therapy: an epidemiologic study","volume":"12","author":"Malberti","year":"2001","journal-title":"J. Am. Soc. Nephrol."},{"key":"2026081210362131300_bib55","doi-asserted-by":"crossref","first-page":"bqab084","DOI":"10.1210\/endocr\/bqab084","article-title":"Local NF-\u03baB activation promotes parathyroid hormone synthesis and secretion in uremic patients","volume":"162","author":"Mao","year":"2021","journal-title":"Endocrinology"},{"key":"2026081210362131300_bib56","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00726-022-03126-8","article-title":"Integrated transcriptomic and proteomic analyses for the characterization of parathyroid oxyphil cells in uremic patients","volume":"54","author":"Mao","year":"2022","journal-title":"Amino Acids"},{"key":"2026081210362131300_bib57","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.kint.2023.11.027","article-title":"Single-cell RNA sequencing reveals transdifferentiation of parathyroid chief cells into oxyphil cells in patients with uremic secondary hyperparathyroidism","volume":"105","author":"Mao","year":"2024","journal-title":"Kidney Int."},{"key":"2026081210362131300_bib58","doi-asserted-by":"crossref","first-page":"44799","DOI":"10.1038\/srep44799","article-title":"Upregulation of skeletal muscle PGC-1\u03b1 through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance","volume":"7","author":"Matsukawa","year":"2017","journal-title":"Sci. Rep."},{"key":"2026081210362131300_bib59","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.celrep.2018.08.036","article-title":"Sarcolipin signaling promotes mitochondrial biogenesis and oxidative metabolism in skeletal muscle","volume":"24","author":"Maurya","year":"2018","journal-title":"Cell Rep."},{"key":"2026081210362131300_bib60","doi-asserted-by":"crossref","first-page":"i15","DOI":"10.1093\/ckj\/sfae423","article-title":"Pathophysiology and therapies of CKD-associated secondary hyperparathyroidism","volume":"18","author":"Mazzaferro","year":"2025","journal-title":"Clin. Kidney J."},{"key":"2026081210362131300_bib61","first-page":"691","article-title":"Functioning oxyphil adenoma of parathyroid gland. An ultrastructural and biochemical study","volume":"92","author":"McGregor","year":"1978","journal-title":"Am. J. Pathol."},{"key":"2026081210362131300_bib62","doi-asserted-by":"crossref","first-page":"36","DOI":"10.2215\/CJN.03591006","article-title":"The OPTIMA study: assessing a new cinacalcet (Sensipar\/Mimpara) treatment algorithm for secondary hyperparathyroidism","volume":"3","author":"Messa","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2026081210362131300_bib63","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11883-022-01078-8","article-title":"From 'omics to multi-omics technologies: the discovery of novel causal mediators","volume":"25","author":"Mohammadi-Shemirani","year":"2023","journal-title":"Curr. Atheroscler. Rep."},{"key":"2026081210362131300_bib64","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4161\/15384101.2014.991572","article-title":"mTOR coordinates protein synthesis, mitochondrial activity and proliferation","volume":"14","author":"Morita","year":"2015","journal-title":"Cell Cycle"},{"key":"2026081210362131300_bib65","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/S0046-8177(96)90158-6","article-title":"Defects of the respiratory chain in oxyphil and chief cells of the normal parathyroid and in hyperfunction","volume":"27","author":"M\u00fcller-H\u00f6cker","year":"1996","journal-title":"Hum. Pathol."},{"key":"2026081210362131300_bib66","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s004280050285","article-title":"Immunohistochemical detection of human mtDNA polymerase gamma and of human mitochondrial transcription factor A in cytochrome-c-oxidase-deficient oxyphil cells of hyperfunctional parathyroids","volume":"433","author":"M\u00fcller-H\u00f6cker","year":"1998","journal-title":"Virchows Arch."},{"key":"2026081210362131300_bib67","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1016\/j.ajpath.2014.07.015","article-title":"Oxyphil cell metaplasia in the parathyroids is characterized by somatic mitochondrial DNA mutations in NADH dehydrogenase genes and cytochrome c oxidase activity-impairing genes","volume":"184","author":"M\u00fcller-H\u00f6cker","year":"2014","journal-title":"Am. J. Pathol."},{"key":"2026081210362131300_bib68","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1124\/jpet.103.057273","article-title":"Pharmacodynamics of the type II calcimimetic compound cinacalcet HCl","volume":"308","author":"Nemeth","year":"2004","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2026081210362131300_bib69","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1097\/PAS.0b013e31820371e4","article-title":"Study of parathyroid transcription factor Gcm2 expression in parathyroid lesions","volume":"35","author":"Nonaka","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"2026081210362131300_bib70","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3164\/jcbn.11-005FR","article-title":"Lipoic acid: energy metabolism and redox regulation of transcription and cell signaling","volume":"48","author":"Packer","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"key":"2026081210362131300_bib71","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.bbagen.2012.01.003","article-title":"Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes","volume":"1820","author":"Piantadosi","year":"2012","journal-title":"Bioch. Biophys. Acta"},{"key":"2026081210362131300_bib71a","doi-asserted-by":"publisher","DOI":"10.20944\/preprints202503.1661.v1","article-title":"Unlocking the mystery of oxyphil cells: their origin, function, and clinical relevance in parathyroid physiology","author":"Pozzi","year":"2025"},{"key":"2026081210362131300_bib72","doi-asserted-by":"crossref","first-page":"7299","DOI":"10.18632\/aging.103078","article-title":"Melatonin improves mitochondrial biogenesis through the AMPK\/PGC1\u03b1 pathway to attenuate ischemia\/reperfusion-induced myocardial damage","volume":"12","author":"Qi","year":"2020","journal-title":"Aging"},{"key":"2026081210362131300_bib73","doi-asserted-by":"crossref","first-page":"836","DOI":"10.2215\/CJN.02910707","article-title":"Contribution of bone and mineral abnormalities to cardiovascular disease in patients with chronic kidney disease","volume":"3","author":"Raggi","year":"2008","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"2026081210362131300_bib74","first-page":"437","article-title":"The role of hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1) in the progression of ovarian cancer:","volume":"14","author":"Rahman","year":"2025","journal-title":"perspectives on female infertility"},{"key":"2026081210362131300_bib75","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/s41598-018-19930-w","article-title":"Mitochondrial biogenesis and metabolic hyperactivation limits the application of MTT assay in the estimation of radiation induced growth inhibition","volume":"8","author":"Rai","year":"2018","journal-title":"Sci. Rep."},{"key":"2026081210362131300_bib76","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.kint.2017.05.003","article-title":"Paricalcitol and cinacalcet have disparate actions on parathyroid oxyphil cell content in patients with chronic kidney disease","volume":"92","author":"Ritter","year":"2017","journal-title":"Kidney Int."},{"key":"2026081210362131300_bib77","doi-asserted-by":"crossref","first-page":"E1499","DOI":"10.1210\/jc.2011-3366","article-title":"Differential gene expression by oxyphil and chief cells of human parathyroid glands","volume":"97","author":"Ritter","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2026081210362131300_bib78","doi-asserted-by":"crossref","first-page":"S155","DOI":"10.1046\/j.1523-1755.61.s80.26.x","article-title":"Pathogenesis of refractory secondary hyperparathyroidism","volume":"61","author":"Rodriguez","year":"2002","journal-title":"Kidney Int."},{"key":"2026081210362131300_bib79","doi-asserted-by":"crossref","first-page":"490","DOI":"10.5603\/ep.95820","article-title":"Secondary hyperparathyroidism in chronic kidney disease: pathomechanism and current treatment possibilities","volume":"74","author":"Rodzo\u0144-Norwicz","year":"2023","journal-title":"Endokrynol. Pol."},{"key":"2026081210362131300_bib80","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.arcmed.2014.04.002","article-title":"Protein-bound uremic toxins, inflammation and oxidative stress: a cross-sectional study in stage 3\u20134 chronic kidney disease","volume":"45","author":"Rossi","year":"2014","journal-title":"Arch. Med. Res."},{"key":"2026081210362131300_bib81","first-page":"933","article-title":"The eosinophilic cells of the parathyroid (oxyphil cells), salivary (oncocytes), and thyroid (Huerthle cells) glands. Light and electron microscopic observations","volume":"11","author":"Roth","year":"1962","journal-title":"Lab. Invest."},{"key":"2026081210362131300_bib82","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/ckj\/sfy062","article-title":"Are oxyphil cells responsible for the ineffectiveness of cinacalcet hydrochloride in haemodialysis patients?","volume":"12","author":"Rottembourg","year":"2019","journal-title":"Clin. Kidney J."},{"key":"2026081210362131300_bib83","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1365-2559.1984.tb02353.x","article-title":"The normal parathyroid and the borderline with early hyperplasia: a light microscopic study","volume":"8","author":"Saffos","year":"1984","journal-title":"Histopathology"},{"key":"2026081210362131300_bib84","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1073\/pnas.1319742111","article-title":"Functional and genetic studies of isolated cells from parathyroid tumors reveal the complex pathogenesis of parathyroid neoplasia","volume":"111","author":"Shi","year":"2014","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2026081210362131300_bib85","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.molmed.2023.09.004","article-title":"Multiomics tools for improved atherosclerotic cardiovascular disease management","volume":"29","author":"Sopic","year":"2023","journal-title":"Trends Mol. Med."},{"key":"2026081210362131300_bib86","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1136\/jclinpath-2011-200100","article-title":"Histopathological alterations of the parathyroid glands in haemodialysis patients with secondary hyperparathyroidism refractory to cinacalcet hydrochloride","volume":"64","author":"Sumida","year":"2011","journal-title":"J. Clin. Pathol."},{"key":"2026081210362131300_bib87","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/bs.adgen.2015.11.004","article-title":"Integrative analysis of multi-omics data for discovery and functional studies of complex human diseases","volume":"93","author":"Sun","year":"2016","journal-title":"Adv. Genet."},{"key":"2026081210362131300_bib88","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s004280050209","article-title":"Oncocytic tumours","volume":"433","author":"Tallini","year":"1998","journal-title":"Virchows Arch."},{"key":"2026081210362131300_bib89","first-page":"580","article-title":"Oxyphil cell function in secondary parathyroid hyperplasia","volume":"73","author":"Tanaka","year":"1996","journal-title":"Nephron"},{"key":"2026081210362131300_bib90","doi-asserted-by":"crossref","first-page":"e13247","DOI":"10.14814\/phy2.13247","article-title":"Cycling our way to fit fat","volume":"5","author":"Townsend","year":"2017","journal-title":"Physiol. Rep."},{"key":"2026081210362131300_bib91","doi-asserted-by":"crossref","first-page":"100238","DOI":"10.1016\/j.clinme.2024.100238","article-title":"Secondary hyperparathyroidism in chronic kidney disease: a narrative review focus on therapeutic strategy","volume":"24","author":"Tsai","year":"2024","journal-title":"Clin. Med."},{"key":"2026081210362131300_bib92","doi-asserted-by":"crossref","first-page":"pgad073","DOI":"10.1093\/pnasnexus\/pgad073","article-title":"Digital spatial profiling of human parathyroid tumors reveals cellular and molecular alterations linked to vitamin D deficiency","volume":"2","author":"Tu","year":"2023","journal-title":"PNAS Nexus"},{"key":"2026081210362131300_bib93","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1046\/j.1492-7535.2003.00034.x","article-title":"An overview of uremic toxicity","volume":"7","author":"Vanholder","year":"2003","journal-title":"Hemodial. Int."},{"key":"2026081210362131300_bib94","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1101\/gr.278215.123","article-title":"Single-cell analysis reveals transcriptional dynamics in healthy primary parathyroid tissue","volume":"34","author":"Venkat","year":"2024","journal-title":"Genome Res."},{"key":"2026081210362131300_bib95","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/1744-9987.12604","article-title":"Parathyroid nodular hyperplasia and responsiveness to drug therapy in renal secondary hyperparathyroidism: an open question","volume":"22","author":"Vulpio","year":"2018","journal-title":"Ther. Apher. Dial."},{"key":"2026081210362131300_bib96","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1542-4758.2010.00514.x","article-title":"Switch from calcitriol to paricalcitol in secondary hyperparathyroidism of hemodialysis patients: responsiveness is related to parathyroid gland size","volume":"15","author":"Vulpio","year":"2011","journal-title":"Hemodial. Int."},{"key":"2026081210362131300_bib97","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jprot.2013.12.023","article-title":"Root proteome of rice studied by iTRAQ provides integrated insight into aluminum stress tolerance mechanisms in plants","volume":"98","author":"Wang","year":"2014","journal-title":"J. Proteomics"},{"key":"2026081210362131300_bib98","doi-asserted-by":"crossref","first-page":"eaaw3381","DOI":"10.1126\/science.aaw3381","article-title":"Lineage tracing on transcriptional landscapes links state to fate during differentiation","volume":"367","author":"Weinreb","year":"2020","journal-title":"Science"},{"key":"2026081210362131300_bib99","first-page":"380","article-title":"Concerning the parathyroid glands: a critical, anatomical, and experimental study","volume":"32","author":"Welsh","year":"1898","journal-title":"J. Anat. Physiol."},{"key":"2026081210362131300_bib100","doi-asserted-by":"crossref","first-page":"18793","DOI":"10.1074\/jbc.M611252200","article-title":"Calcium induces increases in peroxisome proliferator-activated receptor gamma coactivator-1\u03b1 and mitochondrial biogenesis by a pathway leading to p38 mitogen-activated protein kinase activation","volume":"282","author":"Wright","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2026081210362131300_bib101","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s13046-024-03094-9","article-title":"Tumor promoting effect of PDLIM2 downregulation involves mitochondrial ROS, oncometabolite accumulations and HIF-1\u03b1 activation","volume":"43","author":"Yang","year":"2024","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"2026081210362131300_bib102","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1093\/ndt\/gfy194","article-title":"Prostaglandin E2 receptor EP2 mediates the effect of cyclooxygenase 2 on secondary parathyroid hyperplasia in end-stage renal disease","volume":"34","author":"Zhang","year":"2019","journal-title":"Nephrol. Dial. Transplant."},{"key":"2026081210362131300_bib103","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1681\/ASN.2010060594","article-title":"Cyclooxygenase 2 promotes parathyroid hyperplasia in ESRD","volume":"22","author":"Zhang","year":"2011","journal-title":"J. Am. Soc. Nephrol."},{"key":"2026081210362131300_bib104","doi-asserted-by":"crossref","first-page":"1603955","DOI":"10.3389\/fendo.2025.1603955","article-title":"Single cell sequencing revealed parathyroid oxyphil cells are involved in osteoporosis under primary hyperparathyroidism","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Endocrinol."}],"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjaf061\/66209482\/mjaf061.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/article-pdf\/doi\/10.1093\/jmcb\/mjaf061\/66209482\/mjaf061.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/article-pdf\/doi\/10.1093\/jmcb\/mjaf061\/66209482\/mjaf061.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T14:36:41Z","timestamp":1786545401000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/article\/doi\/10.1093\/jmcb\/mjaf061\/8408464"}},"subtitle":[],"editor":[{"given":"Wei-Ping","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":105,"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mjaf061","relation":{},"ISSN":["1674-2788","1759-4685"],"issn-type":[{"value":"1674-2788","type":"print"},{"value":"1759-4685","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"mjaf061"}}