{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:39:54Z","timestamp":1792600794727,"version":"4.5.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":90,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341098"],"award-info":[{"award-number":["82341098"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130052"],"award-info":[{"award-number":["82130052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The NLRP3 inflammasome plays a pivotal role in mediating pro-inflammatory cytokine release and inducing pyroptosis. Its aberrant activation is implicated in various inflammatory diseases, including gout, a condition characterized by monosodium urate crystal deposition in the ankle joint. Here, we identify \u03b2-alanine, an endogenous amino acid, as a novel NLRP3 inflammasome inhibitor with promising therapeutic potential for gout. Mechanistic investigations reveal that \u03b2-alanine binds to NLRP3, sequestering it within the trans-Golgi network. This interaction disrupts NLRP3 inflammasome assembly, thereby inhibiting the secretion of interleukin-1\u03b2 (IL-1\u03b2) and IL-18. Moreover, in vivo experiments demonstrate that \u03b2-alanine administration significantly alleviates monosodium urate crystal-induced inflammation and joint swelling in mice without evident toxicity. Collectively, our findings not only uncover a novel endogenous regulatory mechanism for NLRP3-driven inflammation but also position \u03b2-alanine as a potential therapeutic candidate for gout.<\/jats:p>","DOI":"10.1093\/jmcb\/mjag004","type":"journal-article","created":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T11:35:37Z","timestamp":1774956937000},"source":"Crossref","is-referenced-by-count":2,"title":["\u03b2-alanine alleviates gout by inhibiting NLRP3 inflammasome activation"],"prefix":"10.1093","volume":"18","author":[{"given":"Xia-Ying","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Translational Medicine, Zhejiang University , Hangzhou 310029 ,","place":["China"]},{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng-Peng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Zhejiang University , Hangzhou 310029 ,","place":["China"]},{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3448-0040","authenticated-orcid":false,"given":"Ying","family":"Yuan","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Zhejiang University , Hangzhou 310029 ,","place":["China"]},{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Qin","family":"Xu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Zhejiang University , Hangzhou 310029 ,","place":["China"]},{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Bing","family":"Yu","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xue","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Zhejiang University , Hangzhou 310029 ,","place":["China"]},{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine, Zhejiang University , Hangzhou 310029 ,","place":["China"]},{"name":"Nanhu Laboratory, National Center of Biomedical Analysis , Beijing 100039 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"2026102111492285100_bib1","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1038\/s41418-022-00997-y","article-title":"GSK3\u03b2 mediates the spatiotemporal dynamics of NLRP3 inflammasome activation","volume":"29","author":"Arumugam","year":"2022","journal-title":"Cell Death Differ."},{"key":"2026102111492285100_bib2","doi-asserted-by":"crossref","first-page":"108756","DOI":"10.1016\/j.celrep.2021.108756","article-title":"Itaconate confers tolerance to late NLRP3 inflammasome activation","volume":"34","author":"Bambouskova","year":"2021","journal-title":"Cell Rep."},{"key":"2026102111492285100_bib2a","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1152\/physrev.00039.2012","article-title":"Physiology and pathophysiology of carnosine","volume":"93","author":"Boldyrev","year":"2013","journal-title":"Physiol. Rev."},{"key":"2026102111492285100_bib3","doi-asserted-by":"crossref","first-page":"e78609","DOI":"10.7554\/eLife.78609","article-title":"Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death","volume":"11","author":"Borges","year":"2022","journal-title":"eLife"},{"key":"2026102111492285100_bib4","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"2026102111492285100_bib5","doi-asserted-by":"crossref","first-page":"e2308749","DOI":"10.1002\/smll.202308749","article-title":"Monosodium urate crystal-induced pyroptotic cell death in neutrophil and macrophage facilitates the pathological progress of gout","volume":"20","author":"Chen","year":"2024","journal-title":"Small"},{"key":"2026102111492285100_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1038\/s41586-018-0761-3","article-title":"PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation","volume":"564","author":"Chen","year":"2018","journal-title":"Nature"},{"key":"2026102111492285100_bib7","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.nut.2018.10.011","article-title":"Effects of dietary sports supplements on metabolite accumulation, vasodilation and cellular swelling in relation to muscle hypertrophy: a focus on \u2018secondary\u2019 physiological determinants","volume":"60","author":"Cholewa","year":"2019","journal-title":"Nutrition"},{"key":"2026102111492285100_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/s41572-019-0115-y","article-title":"Gout","volume":"5","author":"Dalbeth","year":"2019","journal-title":"Nat. Rev. Dis. Primers"},{"key":"2026102111492285100_bib9","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/S0140-6736(21)00569-9","article-title":"Gout","volume":"397","author":"Dalbeth","year":"2021","journal-title":"Lancet"},{"key":"2026102111492285100_bib10","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/s41584-020-0441-1","article-title":"Global epidemiology of gout: prevalence, incidence, treatment patterns and risk factors","volume":"16","author":"Dehlin","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"2026102111492285100_bib11","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1038\/ncomms11929","article-title":"ASC filament formation serves as a signal amplification mechanism for inflammasomes","volume":"7","author":"Dick","year":"2016","journal-title":"Nat. Commun."},{"key":"2026102111492285100_bib12","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fphar.2017.00278","article-title":"Potential of IL-1, IL-18 and inflammasome inhibition for the treatment of inflammatory skin diseases","volume":"8","author":"Fenini","year":"2017","journal-title":"Front. Pharmacol."},{"key":"2026102111492285100_bib13","doi-asserted-by":"crossref","first-page":"111770","DOI":"10.1016\/j.celrep.2022.111770","article-title":"GABA regulates IL-1\u03b2 production in macrophages","volume":"41","author":"Fu","year":"2022","journal-title":"Cell Rep."},{"key":"2026102111492285100_bib14","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu. Rev. Immunol."},{"key":"2026102111492285100_bib15","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12970-018-0238-7","article-title":"\u03b2-alanine supplementation increased physical performance and improved executive function following endurance exercise in middle aged individuals","volume":"15","author":"Furst","year":"2018","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"2026102111492285100_bib16","doi-asserted-by":"crossref","first-page":"C777","DOI":"10.1152\/ajpcell.00550.2019","article-title":"Insulin does not stimulate \u03b2-alanine transport into human skeletal muscle","volume":"318","author":"Gon\u00e7alves","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"2026102111492285100_bib17","doi-asserted-by":"crossref","first-page":"107848","DOI":"10.1016\/j.celrep.2020.107848","article-title":"Metabolic modulation of immunity: a new concept in cancer immunotherapy","volume":"32","author":"Guerra","year":"2020","journal-title":"Cell Rep."},{"key":"2026102111492285100_bib18","doi-asserted-by":"crossref","first-page":"12991","DOI":"10.3168\/jds.2024-26088","article-title":"Effect of different types of milk consumption on gout and the mediating effect of branched chain amino acids (BCAAs): a mendelian randomization study","volume":"108","author":"Han","year":"2025","journal-title":"J. Dairy Sci."},{"key":"2026102111492285100_bib19","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nature16959","article-title":"NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux","volume":"530","author":"He","year":"2016","journal-title":"Nature"},{"key":"2026102111492285100_bib20","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00726-014-1896-7","article-title":"\u03b2-alanine ingestion increases muscle carnosine content and combat specific performance in soldiers","volume":"47","author":"Hoffman","year":"2015","journal-title":"Amino Acids"},{"key":"2026102111492285100_bib21","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.cmet.2020.07.016","article-title":"The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation","volume":"32","author":"Hooftman","year":"2020","journal-title":"Cell Metab."},{"key":"2026102111492285100_bib22","doi-asserted-by":"crossref","first-page":"101223","DOI":"10.1016\/j.redox.2019.101223","article-title":"Taurine and its analogs in neurological disorders: focus on therapeutic potential and molecular mechanisms","volume":"24","author":"Jakaria","year":"2019","journal-title":"Redox. Biol."},{"key":"2026102111492285100_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13075-021-02472-4","article-title":"Neutrophil extracellular trap clearance by synovial macrophages in gout","volume":"23","author":"Jeong","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"2026102111492285100_bib24","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/art.42523","article-title":"Prediagnostic glycoprotein acetyl levels and incident and recurrent flare risk accounting for serum urate levels: a population-based, prospective study and mendelian randomization analysis","volume":"75","author":"Joshi","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"2026102111492285100_bib25","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1161\/ATVBAHA.117.310581","article-title":"Saturated fatty acids undergo intracellular crystallization and activate the NLRP3 inflammasome in macrophages","volume":"38","author":"Karasawa","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2026102111492285100_bib26","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41586-021-03218-7","article-title":"NINJ1 mediates plasma membrane rupture during lytic cell death","volume":"591","author":"Kayagaki","year":"2021","journal-title":"Nature"},{"key":"2026102111492285100_bib27","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/s41583-023-00724-7","article-title":"GABA tone regulation and its cognitive functions in the brain","volume":"24","author":"Koh","year":"2023","journal-title":"Nat. Rev. Neurosci."},{"key":"2026102111492285100_bib28","doi-asserted-by":"crossref","first-page":"eaas8995","DOI":"10.1126\/science.aas8995","article-title":"HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation","volume":"369","author":"Magupalli","year":"2020","journal-title":"Science"},{"key":"2026102111492285100_bib29","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12199-017-0609-8","article-title":"Alteration in plasma free amino acid levels and its association with gout","volume":"22","author":"Mahbub","year":"2017","journal-title":"Environ. Health Prev. Med."},{"key":"2026102111492285100_bib30","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"2026102111492285100_bib31","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S1097-2765(02)00599-3","article-title":"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-\u03b2","volume":"10","author":"Martinon","year":"2002","journal-title":"Mol. Cell"},{"key":"2026102111492285100_bib32","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature04516","article-title":"Gout-associated uric acid crystals activate the NALP3 inflammasome","volume":"440","author":"Martinon","year":"2006","journal-title":"Nature"},{"key":"2026102111492285100_bib33","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1002\/acr.25420","article-title":"Prediagnostic amino acid metabolites and risk of gout, accounting for serum urate: prospective cohort study and mendelian randomization","volume":"76","author":"McCormick","year":"2024","journal-title":"Arthritis Care Res."},{"key":"2026102111492285100_bib34","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.immuni.2025.01.007","article-title":"NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer\u2019s disease progression","volume":"58","author":"McManus","year":"2025","journal-title":"Immunity"},{"key":"2026102111492285100_bib35","first-page":"1181","article-title":"Biochemical mechanisms of beneficial effects of beta-alanine supplements on cognition","volume":"88","author":"Meftahi","year":"2023","journal-title":"Biochemistry"},{"key":"2026102111492285100_bib36","doi-asserted-by":"crossref","first-page":"1232629","DOI":"10.3389\/fimmu.2023.1232629","article-title":"Reframing the link between metabolism and NLRP3 inflammasome: therapeutic opportunities","volume":"14","author":"Ortega","year":"2023","journal-title":"Front. Immunol."},{"key":"2026102111492285100_bib37","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1088\/0031-9155\/32\/8\/001","article-title":"The passive electrical properties of biological systems: their significance in physiology, biophysics and biotechnology","volume":"32","author":"Pethig","year":"1987","journal-title":"Phys. Med. Biol."},{"key":"2026102111492285100_bib38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev-nutr-071816-064836","article-title":"Fatty acids and NLRP3 inflammasome-mediated inflammation in metabolic tissues","volume":"37","author":"Ralston","year":"2017","journal-title":"Annu. Rev. Nutr."},{"key":"2026102111492285100_bib39","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/s41375-019-0436-6","article-title":"NLRP3 inflammasome couples purinergic signaling with activation of the complement cascade for the optimal release of cells from bone marrow","volume":"33","author":"Ratajczak","year":"2019","journal-title":"Leukemia"},{"key":"2026102111492285100_bib40","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1136\/annrheumdis-2020-217342","article-title":"Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1\u03b2 activation on macrophages","volume":"79","author":"Renaudin","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"2026102111492285100_bib41","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.immuni.2022.10.021","article-title":"IKK\u03b2 primes inflammasome formation by recruiting NLRP3 to the trans-Golgi network","volume":"55","author":"Schmacke","year":"2022","journal-title":"Immunity"},{"key":"2026102111492285100_bib42","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41590-021-00886-5","article-title":"NLRP3 inflammasome in cancer and metabolic diseases","volume":"22","author":"Sharma","year":"2021","journal-title":"Nat. Immunol."},{"key":"2026102111492285100_bib43","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1186\/s12974-020-01948-5","article-title":"\u03b2-hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer\u2019s disease pathology","volume":"17","author":"Shippy","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"2026102111492285100_bib44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.molcel.2017.08.017","article-title":"NLRP3 phosphorylation is an essential priming event for inflammasome activation","volume":"68","author":"Song","year":"2017","journal-title":"Mol. Cell"},{"key":"2026102111492285100_bib45","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.neuint.2010.06.001","article-title":"Beta-alanine as a small molecule neurotransmitter","volume":"57","author":"Tiedje","year":"2010","journal-title":"Neurochem. Int."},{"key":"2026102111492285100_bib46","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s12970-015-0090-y","article-title":"International society of sports nutrition position stand: beta-alanine","volume":"12","author":"Trexler","year":"2015","journal-title":"J. Int. Soc. Sports Nutr."},{"key":"2026102111492285100_bib47","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.colsurfb.2006.02.001","article-title":"Weakly and strongly associated nonfreezable water bound in bones","volume":"48","author":"Turov","year":"2006","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"2026102111492285100_bib48","doi-asserted-by":"crossref","first-page":"e3000354","DOI":"10.1371\/journal.pbio.3000354","article-title":"MCC950\/CRID3 potently targets the NACHT domain of wild-type NLRP3 but not disease-associated mutants for inflammasome inhibition","volume":"17","author":"Vande Walle","year":"2019","journal-title":"PLoS Biol."},{"key":"2026102111492285100_bib49","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/s41577-021-00588-x","article-title":"Inflammasome activation at the crux of severe COVID-19","volume":"21","author":"Vora","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"2026102111492285100_bib50","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.molcel.2024.01.002","article-title":"Serine synthesis sustains macrophage IL-1\u03b2 production via NAD+-dependent protein acetylation","volume":"84","author":"Wang","year":"2024","journal-title":"Mol. Cell"},{"key":"2026102111492285100_bib51","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.molcel.2022.12.002","article-title":"Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy","volume":"83","author":"Wang","year":"2023","journal-title":"Mol. Cell"},{"key":"2026102111492285100_bib52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11274-021-03042-1","article-title":"Advances in biotechnological production of \u03b2-alanine","volume":"37","author":"Wang","year":"2021","journal-title":"World J. Microbiol. Biotechnol."},{"key":"2026102111492285100_bib53","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1002\/art.42635","article-title":"Metabolomics and machine learning identify metabolic differences and potential biomarkers for frequent versus infrequent gout flares","volume":"75","author":"Wang","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"2026102111492285100_bib54","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","article-title":"The NLRP3 inflammasome: activation and regulation","volume":"48","author":"Xu","year":"2023","journal-title":"Trends Biochem. Sci."},{"key":"2026102111492285100_bib55","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nm.3804","article-title":"The ketone metabolite \u03b2-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease","volume":"21","author":"Youm","year":"2015","journal-title":"Nat. Med."},{"key":"2026102111492285100_bib56","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41420-023-01438-6","article-title":"Oligomeric states of ASC specks regulate inflammatory responses by inflammasome in the extracellular space","volume":"9","author":"Yu","year":"2023","journal-title":"Cell Death Discov"},{"key":"2026102111492285100_bib57","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-1-0716-2144-8_7","article-title":"Detection of ASC oligomerization by western blotting","volume":"2459","author":"Zangiabadi","year":"2022","journal-title":"Methods Mol. Biol."},{"key":"2026102111492285100_bib57a","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/j.cell.2021.03.002","article-title":"Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis","volume":"184","author":"Zhang","year":"2021","journal-title":"Cell"},{"key":"2026102111492285100_bib58","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12974-024-03254-w","article-title":"Glutamine metabolism modulates microglial NLRP3 inflammasome activity through mitophagy in Alzheimer\u2019s disease","volume":"21","author":"Zhang","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"2026102111492285100_bib59","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/s41590-022-01355-3","article-title":"Distinct changes in endosomal composition promote NLRP3 inflammasome activation","volume":"24","author":"Zhang","year":"2023","journal-title":"Nat. Immunol."},{"key":"2026102111492285100_bib60","doi-asserted-by":"crossref","first-page":"2375","DOI":"10.1016\/j.cell.2024.04.002","article-title":"Alanyl-tRNA synthetase, AARS1, is a lactate sensor and lactyltransferase that lactylates p53 and contributes to tumorigenesis","volume":"187","author":"Zong","year":"2024","journal-title":"Cell"}],"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjag004\/67717762\/mjag004.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/article-pdf\/doi\/10.1093\/jmcb\/mjag004\/67717762\/mjag004.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/article-pdf\/doi\/10.1093\/jmcb\/mjag004\/67717762\/mjag004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:49:37Z","timestamp":1792597777000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/article\/doi\/10.1093\/jmcb\/mjag004\/8571582"}},"subtitle":[],"editor":[{"given":"Weiwei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":62,"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mjag004","relation":{},"ISSN":["1674-2788","1759-4685"],"issn-type":[{"value":"1674-2788","type":"print"},{"value":"1759-4685","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"mjag004"}}