{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:19:53Z","timestamp":1787753993298,"version":"build-2784847793"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\u03b2-Amyloid precursor protein (APP), an amyloid \u03b2-peptide (A\u03b2) generating protein, plays a central role in Alzheimer\u2019s disease (AD). Its intracellular trafficking and proteolytic processing are precisely regulated, but the mechanisms remain elusive. Here, we identified LAMTOR1 as a novel APP intracellular domain binding partner that sorts APP from early endosomes to late endosomes. Knockout of LAMTOR1 decreased APP trafficking to late endosomes, which promoted its amyloidogenic processing on early endosomes, resulting in increased A\u03b2. Conditional knockout of LAMTOR1 in Camk2a-expressing neurons impaired memory function in AD mouse model. Furthermore, the targeting of APP to late endosomes is mediated by adaptor protein complex 3 (AP-3). AP-3 bound to LAMTOR1, and its depletion caused accumulation of LAMTOR1 and APP within early endosomes, subsequently increasing A\u03b2. Thus, LAMTOR1 functions as a regulator of APP trafficking to late endosomes and may serve as a potential therapeutic target for AD.<\/jats:p>","DOI":"10.1093\/jmcb\/mjag033","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:40:31Z","timestamp":1787658031000},"source":"Crossref","is-referenced-by-count":0,"title":["LAMTOR1 sorts APP to late endosomes via AP-3-mediated trafficking"],"prefix":"10.1093","author":[{"given":"Chenqian","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rixu","family":"Cong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Shan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglu","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Psychological and Cognitive Sciences, Peking University , Beijing 100871 ,","place":["China"]},{"name":"Center for Quantitative Biology, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sizheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiran","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanjun","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Common Mechanism Research for Major Diseases, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College , Suzhou 215123 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junlin","family":"Teng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3797-4023","authenticated-orcid":false,"given":"Pengli","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]},{"name":"Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Huang","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience, Translational Medicine Institute, Health Science Center, Xi\u2019an Jiaotong University , Xi\u2019an 710061 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, State Key Laboratory of Membrane Biology, College of Life Sciences, Peking University , Beijing 100871 ,","place":["China"]},{"name":"Center for Quantitative Biology, Peking University , Beijing 100871 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,26]]},"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjag033\/70797236\/mjag033.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjag033\/70797236\/mjag033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T13:21:51Z","timestamp":1787750511000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article\/doi\/10.1093\/jmcb\/mjag033\/8770967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mjag033","relation":{},"ISSN":["1674-2788","1759-4685"],"issn-type":[{"value":"1674-2788","type":"print"},{"value":"1759-4685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,26]]},"article-number":"mjag033"}}