{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:03:57Z","timestamp":1790701437197,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:00:00Z","timestamp":1790640000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>WD-repeat domain 5 (Wdr5), a core component of the SET1\/MLL family of histone methyltransferases, is widely involved in the regulation of development, epigenetic control, transcription, and cell division. Wdr5 has been linked to neurodevelopmental disorders characterized by intellectual disability and developmental delay\u2014yet its regulatory roles in neurons remain poorly understood. Here, we report that postnatal deletion of Wdr5 in excitatory forebrain neurons impairs learning and memory in male Wdr5fl\/fl; CaMKII\u03b1-iCre conditional knockout (Wdr5 cKO) mice. We showed that the conditional Wdr5 knockout affects dendritic spine as well as synapse development in cortex and hippocampus. In addition, the expression profile of the hippocampus in response to contextual fear-conditioning tests was dysregulated in the Wdr5 cKO mice, including genes related to Notch signaling and mitochondrial respiratory. The recovery of the expression of the immediate early genes was also impaired in the Wdr5 cKO mice compared to the wild-type mice. Collectively, these findings identify Wdr5 as a critical regulator of synaptic development and memory consolidation.<\/jats:p>","DOI":"10.1093\/jmcb\/mjag037","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T11:27:01Z","timestamp":1790594821000},"source":"Crossref","is-referenced-by-count":0,"title":["Wdr5 Modulates Synaptic Development and Memory Consolidation in the Hippocampus and Cerebral Cortex"],"prefix":"10.1093","author":[{"given":"Huishan","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201 ,","place":["China"]},{"name":"Kunming College of Life Science, University of Chinese Academy of Sciences , Kunming 650203 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1067-8021","authenticated-orcid":false,"given":"Pengcheng","family":"Ma","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuwei","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengju","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201 ,","place":["China"]},{"name":"Yunnan Key Laboratory of Biodiversity Information, KIZ\u2013CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201 ,","place":["China"]},{"name":"Kunming College of Life Science, University of Chinese Academy of Sciences , Kunming 650203 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Li","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Yunnan Province, School of Medicine, Kunming University of Science and Technology Department of Infectious Disease and Hepatic Disease, , Kunming 650500 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Academy of Biomedical Engineering, Kunming Medical University , Kunming 650500 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingyu","family":"Mao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Genetic Evolution and Animal Models, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650201 ,","place":["China"]},{"name":"National Resource Center for Non-Human Primates, Kunming Primate Research Center and National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming 650107 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,29]]},"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjag037\/71466835\/mjag037.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjag037\/71466835\/mjag037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:18:04Z","timestamp":1790698684000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article\/doi\/10.1093\/jmcb\/mjag037\/8845584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mjag037","relation":{},"ISSN":["1674-2788","1759-4685"],"issn-type":[{"value":"1674-2788","type":"print"},{"value":"1759-4685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,29]]},"article-number":"mjag037"}}