{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:56:35Z","timestamp":1791471395383,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Recent advances in natural language processing combined with deep learning have transformed disease prediction, diagnosis, and treatment, yet their application in automated quality control of medical questionnaire data remains largely unexplored. Here, we present an end-to-end system tailored for large-scale cohort interview data. A fine-tuned Whisper model was developed for automatic audio-to-text transcription and optimized for recognizing domain-specific medical terminology and regional dialects, achieving an accuracy of over 91%. Using the DeepSeek framework, we jointly analyzed transcribed texts, interviewer records, and questionnaire content from 522 medical interviews to identify quality issues, achieving the area under the receiver operating characteristic curve (AUC) values of 0.893, 0.953, and 0.973 for omitted question stems, response\u2013record inconsistencies, and insufficient follow-up, respectively. The system achieved high agreement with the senior specialist reference (F1\u00a0=\u00a00.843, Kappa\u00a0=\u00a00.835) and significantly outperformed the junior specialist group (P\u00a0&amp;lt;\u00a00.01). Evaluation on an independent validation dataset (n\u00a0=\u00a096), which was collected using a structurally distinct brain health questionnaire, further demonstrated robust performance and generalizability (F1\u00a0=\u00a00.831, Kappa\u00a0=\u00a00.821). Collectively, this framework enhances the efficiency and reliability of medical questionnaire data processing and offers a practical artificial intelligence-driven solution for quality control in global health data, especially in low-resource dialect settings.<\/jats:p>","DOI":"10.1093\/jmcb\/mjag038","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:49:26Z","timestamp":1791373766000},"source":"Crossref","is-referenced-by-count":0,"title":["A Deep Learning system for Automated Quality Control of Medical Questionnaire data in Large-Scale Cohort Studies"],"prefix":"10.1093","author":[{"given":"Minmin","family":"Cao","sequence":"first","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , Chengdu 610000 ,","place":["China"]},{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Duan","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]},{"name":"School of Computer Science and Technology, Donghua University , Shanghai 201620 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong","family":"Lang","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]},{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]},{"name":"Institute for Proactive Healthcare, Shanghai Jiao Tong University , Shanghai 200240 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinqi","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Information Technology, Shanghai Ocean University , Shanghai 201306 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhouyu","family":"Guan","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]},{"name":"School of Public Health, Shanghai Jiao Tong University School of Medicine , Shanghai 200025 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinming","family":"Xu","sequence":"additional","affiliation":[{"name":"Chengdu University of Traditional Chinese Medicine , Chengdu 610000 ,","place":["China"]},{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Cheng","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Nicheng Community Health Service Center , Pudong New District, Shanghai 201306 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keqing","family":"Dong","sequence":"additional","affiliation":[{"name":"Nicheng Community Health Service Center , Pudong New District, Shanghai 201306 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijun","family":"Wang","sequence":"additional","affiliation":[{"name":"Nicheng Community Health Service Center , Pudong New District, Shanghai 201306 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Sheng","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]},{"name":"MoE Key Lab of Artificial Intelligence, Artificial Intelligence Institute, Shanghai Jiao Tong University , Shanghai 200240 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huating","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiping","family":"Jia","sequence":"additional","affiliation":[{"name":"Shanghai Sixth People\u2019s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Belt and Road International Joint Laboratory of Intelligent Prevention and Treatment for Metabolic Diseases Department of Endocrinology and Metabolism, , Shanghai 200233 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,8]]},"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjag038\/71718579\/mjag038.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjag038\/71718579\/mjag038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:22:25Z","timestamp":1791469345000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/advance-article\/doi\/10.1093\/jmcb\/mjag038\/8885588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mjag038","relation":{},"ISSN":["1674-2788","1759-4685"],"issn-type":[{"value":"1674-2788","type":"print"},{"value":"1759-4685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]},"article-number":"mjag038"}}