{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T02:29:15Z","timestamp":1791512955464,"version":"4.3.4"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,10,1]]},"DOI":"10.1093\/jmcb\/mju024","type":"journal-article","created":{"date-parts":[[2014,5,17]],"date-time":"2014-05-17T04:23:52Z","timestamp":1400300632000},"page":"409-420","source":"Crossref","is-referenced-by-count":22,"title":["Small molecule compound induces chromatin de-condensation and facilitates induced pluripotent stem cell generation"],"prefix":"10.1093","volume":"6","author":[{"given":"Xiaoyuan","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueting","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongyu","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuhong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fajun","family":"Nan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,15]]},"reference":[{"key":"key\n\t\t\t\t20170502111729_MJU024C1","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1128\/MCB.26.7.2560-2569.2006","article-title":"Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin","volume":"26","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C2","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.cell.2012.08.023","article-title":"Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase","volume":"150","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C3","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.stem.2011.11.003","article-title":"Reprogramming factor stoichiometry influences the epigenetic state and biological properties of induced pluripotent stem cells","volume":"9","year":"2011","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C4","doi-asserted-by":"crossref","first-page":"16699","DOI":"10.1073\/pnas.1107616108","article-title":"Diverse factors are involved in maintaining X chromosome inactivation","volume":"108","year":"2011","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170502111729_MJU024C5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.biolcel.2004.06.003","article-title":"Heterochromatin structure and function","volume":"96","year":"2004","journal-title":"Biol. Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.stem.2008.03.021","article-title":"Global transcription in pluripotent embryonic stem cells","volume":"2","year":"2008","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C7","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ncb1827","article-title":"Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb","volume":"11","year":"2009","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C8","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.stem.2013.02.005","article-title":"Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming","volume":"12","year":"2013","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nrm3036","article-title":"Open chromatin in pluripotency and reprogramming","volume":"12","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C10","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1002\/dvdy.21545","article-title":"Chromatin remodeling during mouse and human embryonic stem cell differentiation","volume":"237","year":"2008","journal-title":"Dev. Dyn."},{"key":"key\n\t\t\t\t20170502111729_MJU024C11","first-page":"161","article-title":"Reprogramming of transplanted nuclei in amphibia","year":"1979","journal-title":"Int. Rev. Cytol. Suppl."},{"key":"key\n\t\t\t\t20170502111729_MJU024C12","first-page":"143","article-title":"DNA-methylation analysis by the bisulfite-assisted genomic sequencing method","volume":"200","year":"2002","journal-title":"Methods Mol. Biol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C13","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.cub.2004.08.031","article-title":"Nuclear reprogramming of human somatic cells by xenopus egg extract requires BRG1","volume":"14","year":"2004","journal-title":"Curr. Biol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1242\/dev.020867","article-title":"Epigenetic reprogramming and induced pluripotency","volume":"136","year":"2009","journal-title":"Development"},{"key":"key\n\t\t\t\t20170502111729_MJU024C15","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nbt1418","article-title":"Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds","volume":"26","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C16","doi-asserted-by":"crossref","first-page":"5483","DOI":"10.1073\/pnas.1000599107","article-title":"Characterization of somatic cell nuclear reprogramming by oocytes in which a linker histone is required for pluripotency gene reactivation","volume":"107","year":"2010","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170502111729_MJU024C17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.stem.2010.12.001","article-title":"Reprogramming factor expression initiates widespread targeted chromatin remodeling","volume":"8","year":"2011","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C18","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1242\/jcs.00493","article-title":"An epigenetic road map for histone lysine methylation","volume":"116","year":"2003","journal-title":"J. Cell Sci."},{"key":"key\n\t\t\t\t20170502111729_MJU024C19","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.cell.2007.01.015","article-title":"The role of chromatin during transcription","volume":"128","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C20","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s13238-011-1101-7","article-title":"Transcriptional activators and activation mechanisms","volume":"2","year":"2011","journal-title":"Protein Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C21","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1038\/nrm1355","article-title":"HP1 and the dynamics of heterochromatin maintenance","volume":"5","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C22","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.1158\/0008-5472.CAN-04-2478","article-title":"Valproic acid alters chromatin structure by regulation of chromatin modulation proteins","volume":"65","year":"2005","journal-title":"Cancer Res."},{"key":"key\n\t\t\t\t20170502111729_MJU024C23","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrm1938","article-title":"Chromatin in pluripotent embryonic stem cells and differentiation","volume":"7","year":"2006","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nature07056","article-title":"Dissecting direct reprogramming through integrative genomic analysis","volume":"454","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170502111729_MJU024C25","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.tig.2011.08.002","article-title":"Epigenetic factors influencing resistance to nuclear reprogramming","volume":"27","year":"2011","journal-title":"Trends Genet."},{"key":"key\n\t\t\t\t20170502111729_MJU024C26","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nrg2955","article-title":"Progress in understanding reprogramming to the induced pluripotent state","volume":"12","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"key\n\t\t\t\t20170502111729_MJU024C27","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.cell.2010.04.037","article-title":"Chromatin-remodeling components of the BAF complex facilitate reprogramming","volume":"141","year":"2010","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C28","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1634\/stemcells.2008-1075","article-title":"Induced pluripotent stem cell generation using a single lentiviral stem cell cassette","volume":"27","year":"2009","journal-title":"Stem Cells"},{"key":"key\n\t\t\t\t20170502111729_MJU024C29","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.cell.2012.09.045","article-title":"Facilitators and impediments of the pluripotency reprogramming factors\u2019 initial engagement with the genome","volume":"151","year":"2012","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170502111729_MJU024C30","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1038\/ncb2768","article-title":"Proteomic and genomic approaches reveal critical functions of H3K9 methylation and heterochromatin protein-1gamma in reprogramming to pluripotency","volume":"15","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C31","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1128\/MCB.26.4.1259-1271.2006","article-title":"Chromatin decondensation and nuclear reprogramming by nucleoplasmin","volume":"26","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"key\n\t\t\t\t20170502111729_MJU024C32","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/cr.2011.108","article-title":"Lithium, an anti-psychotic drug, greatly enhances the generation of induced pluripotent stem cells","volume":"21","year":"2011","journal-title":"Cell Res."},{"key":"key\n\t\t\t\t20170502111729_MJU024C33","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/cr.2011.176","article-title":"S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance","volume":"21","year":"2011","journal-title":"Cell Res."},{"key":"key\n\t\t\t\t20170502111729_MJU024C34","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/aps.2013.21","article-title":"iPSCs and small molecules: a reciprocal effort towards better approaches for drug discovery","volume":"34","year":"2013","journal-title":"Acta Pharmacol. Sin."},{"key":"key\n\t\t\t\t20170502111729_MJU024C35","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nature08267","article-title":"iPS cells produce viable mice through tetraploid complementation","volume":"461","year":"2009","journal-title":"Nature"}],"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2017,6,22]],"date-time":"2017-06-22T13:22:38Z","timestamp":1498137758000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/article-lookup\/doi\/10.1093\/jmcb\/mju024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,15]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2014,5,15]]},"published-print":{"date-parts":[[2014,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mju024","relation":{},"ISSN":["1674-2788","1759-4685"],"issn-type":[{"value":"1674-2788","type":"print"},{"value":"1759-4685","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,15]]}}}