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In the present study, abnormal neural and dendritic morphology was observed in the hippocampus following knockout of Atp11b both in vitro and in vivo. Moreover, ATP11B modified synaptic ultrastructure and promoted spine remodeling via the asymmetrical distribution of phosphatidylserine and enhancement of glutamate release, glutamate receptor expression, and intracellular Ca2+ concentration. Furthermore, experimental results also indicate that ATP11B regulated synaptic plasticity in hippocampal neurons through the MAPK14 signaling pathway. In conclusion, our data shed light on the possible mechanisms underlying the regulation of synaptic plasticity and lay the foundation for the exploration of proteins involved in signal transduction during this process.<\/jats:p>","DOI":"10.1093\/jmcb\/mjz042","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T19:13:18Z","timestamp":1559243598000},"page":"688-702","source":"Crossref","is-referenced-by-count":29,"title":["ATP11B deficiency leads to impairment of hippocampal synaptic plasticity"],"prefix":"10.1093","volume":"11","author":[{"given":"Jiao","family":"Wang","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihao","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Feng","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fushuai","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiang","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Computer Engineering and Science, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tieqiao","family":"Wen","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Neural Biology, School of Life Sciences, Shanghai University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,6,1]]},"reference":[{"key":"2020091322441282700_ref1","doi-asserted-by":"crossref","first-page":"10858","DOI":"10.1073\/pnas.0502903102","article-title":"Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival","volume":"102","author":"Akbar","year":"2005","journal-title":"Proc. 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