{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T02:28:23Z","timestamp":1790389703164,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31571387"],"award-info":[{"award-number":["31571387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Heat shock protein 90 (Hsp90) is an abundant molecular chaperone with two isoforms, Hsp90\u03b1 and Hsp90\u03b2. Hsp90\u03b2 deficiency causes embryonic lethality, whereas Hsp90\u03b1 deficiency causes few abnormities except male sterility. In this paper, we reported that Hsp90\u03b1 was exclusively expressed in the retina, testis, and brain. Its deficiency caused retinitis pigmentosa (RP), a disease leading to blindness. In Hsp90\u03b1-deficient mice, the retina was deteriorated and the outer segment of photoreceptor was deformed. Immunofluorescence staining and electron microscopic analysis revealed disintegrated Golgi and aberrant intersegmental vesicle transportation in Hsp90\u03b1-deficient photoreceptors. Proteomic analysis identified microtubule-associated protein 1B (MAP1B) as an Hsp90\u03b1-associated protein in photoreceptors. Hsp\u03b1 deficiency increased degradation of MAP1B by inducing its ubiquitination, causing \u03b1-tubulin deacetylation and microtubule destabilization. Furthermore, the treatment of wild-type mice with 17-DMAG, an Hsp90 inhibitor of geldanamycin derivative, induced the same retinal degeneration as Hsp90\u03b1 deficiency. Taken together, the microtubule destabilization could be the underlying reason for Hsp90\u03b1 deficiency-induced RP.<\/jats:p>","DOI":"10.1093\/jmcb\/mjz048","type":"journal-article","created":{"date-parts":[[2019,8,11]],"date-time":"2019-08-11T11:18:42Z","timestamp":1565522322000},"page":"216-229","source":"Crossref","is-referenced-by-count":41,"title":["The molecular chaperone Hsp90\u03b1 deficiency causes retinal degeneration by disrupting Golgi organization and vesicle transportation in photoreceptors"],"prefix":"10.1093","volume":"12","author":[{"given":"Yuan","family":"Wu","sequence":"first","affiliation":[{"name":"Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiudan","family":"Zheng","sequence":"first","affiliation":[{"name":"Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Ding","sequence":"first","affiliation":[{"name":"Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Wei","sequence":"first","affiliation":[{"name":"Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan","family":"Liao","sequence":"first","affiliation":[{"name":"Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,13]]},"reference":[{"key":"2020042408554539000_ref1","doi-asserted-by":"crossref","first-page":"6099","DOI":"10.1002\/j.1460-2075.1994.tb06956.x","article-title":"A role for Hsp90 in cell cycle control: Wee1 tyrosine kinase activity requires interaction with Hsp90","volume":"13","author":"Aligue","year":"1994","journal-title":"EMBO J."},{"key":"2020042408554539000_ref2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/gm155","article-title":"Retinitis pigmentosa and allied conditions today: a paradigm of translational research","volume":"2","author":"Ayuso","year":"2010","journal-title":"Genome Med."},{"key":"2020042408554539000_ref3","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ajhg.2010.07.022","article-title":"Homozygosity mapping reveals null mutations in FAM161A as a cause of autosomal-recessive retinitis pigmentosa","volume":"87","author":"Bandah-Rozenfeld","year":"2010","journal-title":"Am. 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