{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T06:07:49Z","timestamp":1760854069076,"version":"3.37.3"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,7,24]],"date-time":"2019-07-24T00:00:00Z","timestamp":1563926400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG045781"],"award-info":[{"award-number":["AG045781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,22]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neogenin is a transmembrane receptor critical for multiple cellular processes, including neurogenesis, astrogliogenesis, endochondral bone formation, and iron homeostasis. Here we present evidence that loss of neogenin contributes to pathogenesis of persistent hyperplastic primary vitreous (PHPV) formation, a genetic disorder accounting for ~\u20095% of blindness in the USA. Selective loss of neogenin in neural crest cells (as observed in Wnt1-Cre; Neof\/f mice), but not neural stem cells (as observed in GFAP-Cre and Nestin-Cre; Neof\/f mice), resulted in a dysregulation of neural crest cell migration or delamination, exhibiting features of PHPV-like pathology (e.g. elevated retrolental mass), unclosed retinal fissure, and microphthalmia. These results demonstrate an unrecognized function of neogenin in preventing PHPV pathogenesis, implicating neogenin regulation of neural crest cell delamination\/migration and retinal fissure formation as potential underlying mechanisms of PHPV.<\/jats:p>","DOI":"10.1093\/jmcb\/mjz076","type":"journal-article","created":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T19:09:34Z","timestamp":1562612974000},"page":"17-31","source":"Crossref","is-referenced-by-count":13,"title":["Neogenin-loss in neural crest cells results in persistent hyperplastic primary vitreous formation"],"prefix":"10.1093","volume":"12","author":[{"given":"Sen","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Neuroscience & Regenerative Medicine and Department of Neurology, Augusta University, Augusta, GA 30912, USA"},{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center of PLA, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neuroscience & Regenerative Medicine and Department of Neurology, Augusta University, Augusta, GA 30912, USA"},{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center of PLA, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun-Lin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neuroscience & Regenerative Medicine and Department of Neurology, Augusta University, Augusta, GA 30912, USA"},{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center of PLA, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neuroscience & Regenerative Medicine and Department of Neurology, Augusta University, Augusta, GA 30912, USA"},{"name":"Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin-Xia","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Neuroscience & Regenerative Medicine and Department of Neurology, Augusta University, Augusta, GA 30912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neuroscience & Regenerative Medicine and Department of Neurology, Augusta University, Augusta, GA 30912, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, Daping Hospital, Army Medical Center of PLA, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Mei","sequence":"first","affiliation":[{"name":"Department of Neuroscience & Regenerative Medicine and Department of Neurology, Augusta University, Augusta, GA 30912, USA"},{"name":"Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9071-7598","authenticated-orcid":false,"given":"Wen-Cheng","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Neuroscience & Regenerative Medicine and Department of Neurology, Augusta University, Augusta, GA 30912, USA"},{"name":"Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,23]]},"reference":[{"key":"2020030306395143100_ref1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1067\/mpa.2002.121324","article-title":"Unilateral persistent hyperplastic primary vitreous: course and outcome","volume":"6","author":"Anteby","year":"2002","journal-title":"J. AAPOS"},{"key":"2020030306395143100_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000429697","article-title":"Embryology of the eye and its adnexae","volume":"24","author":"Barishak","year":"1992","journal-title":"Dev. Ophthalmol."},{"key":"2020030306395143100_ref3","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3928\/0191-3913-19841101-03","article-title":"Role of the neural crest in anterior segment development and disease","volume":"21","author":"Beauchamp","year":"1984","journal-title":"J. Pediatr. Ophthalmol. Strabismus"},{"key":"2020030306395143100_ref4","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1242\/dev.128.8.1253","article-title":"Inactivation of the \u03b2-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development","volume":"128","author":"Brault","year":"2001","journal-title":"Development"},{"key":"2020030306395143100_ref5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/j.stem.2011.11.004","article-title":"Fate restriction and multipotency in retinal stem cells","volume":"9","author":"Centanin","year":"2011","journal-title":"Cell Stem Cell"},{"key":"2020030306395143100_ref6","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neuron.2005.10.036","article-title":"Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain","volume":"49","author":"Chen","year":"2006","journal-title":"Neuron"},{"key":"2020030306395143100_ref7","doi-asserted-by":"crossref","first-page":"16620","DOI":"10.1073\/pnas.0808987105","article-title":"Loss of ephrin-A5 function disrupts lens fiber cell packing and leads to cataract","volume":"105","author":"Cooper","year":"2008","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2020030306395143100_ref8","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1111\/j.1471-4159.2008.05485.x","article-title":"Emerging roles for neogenin and its ligands in CNS development","volume":"106","author":"De Vries","year":"2008","journal-title":"J. Neurochem."},{"key":"2020030306395143100_ref9","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1038\/nprot.2011.398","article-title":"Primary culture of chick, mouse or human neural crest cells","volume":"6","author":"Etchevers","year":"2011","journal-title":"Nat. Protoc."},{"key":"2020030306395143100_ref10","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1242\/dev.033548","article-title":"Expression of the Arf tumor suppressor gene is controlled by Tgf\u03b22 during development","volume":"136","author":"Freeman-Anderson","year":"2009","journal-title":"Development"},{"key":"2020030306395143100_ref11","doi-asserted-by":"crossref","first-page":"4200","DOI":"10.1167\/iovs.05-0691","article-title":"Fate maps of neural crest and mesoderm in the mammalian eye","volume":"46","author":"Gage","year":"2005","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2020030306395143100_ref12","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0002-9394(14)70899-2","article-title":"Persistent fetal vasculature (PFV): an integrated interpretation of signs and symptoms associated with persistent hyperplastic primary vitreous (PHPV). LIV Edward Jackson Memorial Lecture","volume":"124","author":"Goldberg","year":"1997","journal-title":"Am. J. Ophthalmol."},{"key":"2020030306395143100_ref13","first-page":"59","article-title":"Unoperated eyes with persistent fetal vasculature","volume":"101","author":"Gulati","year":"2003","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"2020030306395143100_ref14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/jcp.10128","article-title":"Angiopoietin-2 plays an important role in retinal angiogenesis","volume":"192","author":"Hackett","year":"2002","journal-title":"J. Cell. Physiol."},{"key":"2020030306395143100_ref15","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0039-6257(78)90091-7","article-title":"Persistent hyperplastic primary vitreous. A clinicopathologic study of 62 cases and review of the literature","volume":"23","author":"Haddad","year":"1978","journal-title":"Surv. Ophthalmol."},{"key":"2020030306395143100_ref16","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1001\/archopht.123.6.797","article-title":"Persistent fetal ocular vasculature in mice deficient in bax and bak","volume":"123","author":"Hahn","year":"2005","journal-title":"Arch. Ophthalmol."},{"key":"2020030306395143100_ref17","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05216","article-title":"Eye morphogenesis driven by epithelial flow into the optic cup facilitated by modulation of bone morphogenetic protein","volume":"4","author":"Heermann","year":"2015","journal-title":"eLife"},{"key":"2020030306395143100_ref18","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/dvdy.23745","article-title":"Neogenin regulates sonic Hedgehog pathway activity during digit patterning","volume":"241","author":"Hong","year":"2012","journal-title":"Dev. Dyn."},{"key":"2020030306395143100_ref19","doi-asserted-by":"crossref","first-page":"5833","DOI":"10.1523\/JNEUROSCI.4487-15.2016","article-title":"Neogenin promotes BMP2 activation of YAP and Smad1 and enhances astrocytic differentiation in developing mouse neocortex","volume":"36","author":"Huang","year":"2016","journal-title":"J. Neurosci."},{"key":"2020030306395143100_ref20","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/bjo.2004.053595","article-title":"Outcomes in persistent hyperplastic primary vitreous","volume":"89","author":"Hunt","year":"2005","journal-title":"Br. J. Ophthalmol."},{"key":"2020030306395143100_ref21","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s004290050289","article-title":"Regression of the hyaloid vessels and pupillary membrane of the mouse","volume":"200","author":"Ito","year":"1999","journal-title":"Anat. Embryol."},{"key":"2020030306395143100_ref22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/jbiol29","article-title":"Compound developmental eye disorders following inactivation of TGF\u03b2 signaling in neural-crest stem cells","volume":"4","author":"Ittner","year":"2005","journal-title":"J. Biol."},{"key":"2020030306395143100_ref23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0014-4835(79)90164-7","article-title":"Origins of avian ocular and periocular tissues","volume":"29","author":"Johnston","year":"1979","journal-title":"Exp. Eye Res."},{"key":"2020030306395143100_ref24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000584","article-title":"EPHA2 is associated with age-related cortical cataract in mice and humans","volume":"5","author":"Jun","year":"2009","journal-title":"PLoS Genet."},{"key":"2020030306395143100_ref25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cell.2009.07.048","article-title":"TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced FZD4\/\u03b2-catenin signaling","volume":"139","author":"Junge","year":"2009","journal-title":"Cell"},{"key":"2020030306395143100_ref26","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/bies.20445","article-title":"Sorting out Sox10 functions in neural crest development","volume":"28","author":"Kelsh","year":"2006","journal-title":"Bioessays"},{"key":"2020030306395143100_ref27","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s00198-015-3245-4","article-title":"Potential blindness in children of patients with hereditary bone disease","volume":"27","author":"Kheir","year":"2016","journal-title":"Osteoporos. Int."},{"key":"2020030306395143100_ref28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0896-6273(03)00163-6","article-title":"SOX10 maintains multipotency and inhibits neuronal differentiation of neural crest stem cells","volume":"38","author":"Kim","year":"2003","journal-title":"Neuron"},{"key":"2020030306395143100_ref29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/dvdy.10485","article-title":"Comparative analysis of neural crest cell death, migration, and function during vertebrate embryogenesis","volume":"229","author":"Kulesa","year":"2004","journal-title":"Dev. Dyn."},{"key":"2020030306395143100_ref30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0070-2153(08)60153-2","article-title":"Migration and differentiation of neural crest cells","volume":"16","author":"Le Douarin","year":"1980","journal-title":"Curr. Top. Dev. Biol."},{"key":"2020030306395143100_ref31","doi-asserted-by":"crossref","first-page":"3136","DOI":"10.1182\/blood-2009-11-251199","article-title":"Neogenin inhibits HJV secretion and regulates BMP-induced hepcidin expression and iron homeostasis","volume":"115","author":"Lee","year":"2010","journal-title":"Blood"},{"key":"2020030306395143100_ref32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1756-6606-7-10","article-title":"Vps35 haploinsufficiency results in degenerative-like deficit in mouse retinal ganglion neurons and impairment of optic nerve injury-induced gliosis","volume":"7","author":"Liu","year":"2014","journal-title":"Mol. Brain"},{"key":"2020030306395143100_ref33","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nn.2467","article-title":"A robust and high-throughput Cre reporting and characterization system for the whole mouse brain","volume":"13","author":"Madisen","year":"2010","journal-title":"Nat. Neurosci."},{"key":"2020030306395143100_ref34","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1167\/iovs.04-0349","article-title":"Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene","volume":"45","author":"Martin","year":"2004","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2020030306395143100_ref35","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1136\/bjo.85.12.1421","article-title":"Histopathological examination of two cases of anterior staphyloma associated with Peters' anomaly and persistent hyperplastic primary vitreous","volume":"85","author":"Matsubara","year":"2001","journal-title":"Br. J. Ophthalmol."},{"key":"2020030306395143100_ref36","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ydbio.2004.02.001","article-title":"The Netrin receptor Neogenin is required for neural tube formation and somitogenesis in zebrafish","volume":"269","author":"Mawdsley","year":"2004","journal-title":"Dev. Biol."},{"key":"2020030306395143100_ref37","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1167\/iovs.05-1543","article-title":"Ocular abnormalities in mice lacking the ski proto-oncogene","volume":"47","author":"McGannon","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2020030306395143100_ref38","doi-asserted-by":"crossref","first-page":"3848","DOI":"10.1073\/pnas.052484199","article-title":"The Arf tumor suppressor gene promotes hyaloid vascular regression during mouse eye development","volume":"99","author":"McKeller","year":"2002","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2020030306395143100_ref39","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/nature01041","article-title":"RGM is a repulsive guidance molecule for retinal axons","volume":"419","author":"Monnier","year":"2002","journal-title":"Nature"},{"key":"2020030306395143100_ref40","doi-asserted-by":"crossref","first-page":"9360","DOI":"10.1073\/pnas.1631288100","article-title":"Sox9 is required for determination of the chondrogenic cell lineage in the cranial neural crest","volume":"100","author":"Mori-Akiyama","year":"2003","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"2020030306395143100_ref41","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/stem.1861","article-title":"The Netrin\/RGM receptor, Neogenin, controls adult neurogenesis by promoting neuroblast migration and cell cycle exit","volume":"33","author":"O'Leary","year":"2015","journal-title":"Stem Cells"},{"key":"2020030306395143100_ref42","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.celrep.2017.06.051","article-title":"Neogenin recruitment of the WAVE regulatory complex to ependymal and radial progenitor adherensjunctions prevents hydrocephalus","volume":"20","author":"O'Leary","year":"2017","journal-title":"Cell Rep."},{"key":"2020030306395143100_ref43","first-page":"487","article-title":"Persistent hyperplastic primary vitreous: diagnosis, treatment and results","volume":"95","author":"Pollard","year":"1997","journal-title":"Trans. Am. Ophthalmol. Soc."},{"key":"2020030306395143100_ref44","doi-asserted-by":"crossref","first-page":"3681","DOI":"10.1093\/hmg\/dds197","article-title":"ATOH7 mutations cause autosomal recessive persistent hyperplasia of the primary vitreous","volume":"21","author":"Prasov","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"2020030306395143100_ref45","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.1242\/dev.111427","article-title":"Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals","volume":"141","author":"Pryor","year":"2014","journal-title":"Development"},{"key":"2020030306395143100_ref46","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/ncb1156","article-title":"Neogenin mediates the action of repulsive guidance molecule","volume":"6","author":"Rajagopalan","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"2020030306395143100_ref47","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/sj.cdd.4400326","article-title":"High frequency of persistent hyperplastic primary vitreous and cataracts in p53-deficient mice","volume":"5","author":"Reichel","year":"1998","journal-title":"Cell Death Differ."},{"key":"2020030306395143100_ref48","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/j.celrep.2016.04.067","article-title":"Leader cells define directionality of trunk, but not cranial, neural crest cell migration","volume":"15","author":"Richardson","year":"2016","journal-title":"Cell Rep."},{"key":"2020030306395143100_ref49","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3109\/08820538.2012.730098","article-title":"Bilateral persistent hyperplastic primary vitreous: a close mimic of retinoblastoma","volume":"28","author":"Rizvi","year":"2013","journal-title":"Semin. Ophthalmol."},{"key":"2020030306395143100_ref50","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1387\/ijdb.041895ms","article-title":"Development and pathology of the hyaloid, choroidal and retinal vasculature","volume":"48","author":"Saint-Geniez","year":"2004","journal-title":"Int. J. Dev. Biol."},{"key":"2020030306395143100_ref51","doi-asserted-by":"crossref","first-page":"6576","DOI":"10.1038\/ncomms7576","article-title":"EphrinB2 controls vessel pruning through STAT1\u2013JNK3 signalling","volume":"6","author":"Salvucci","year":"2015","journal-title":"Nat. Commun."},{"key":"2020030306395143100_ref52","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1440-1673.2005.01402.x","article-title":"Bilateral persistent hyperplastic primary vitreous","volume":"49","author":"Sanghvi","year":"2005","journal-title":"Australas. Radiol."},{"key":"2020030306395143100_ref53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.modgep.2007.09.002","article-title":"Gene expression of the repulsive guidance molecules\/neogenin in the developing and mature mouse visual system: C57BL\/6J vs. the glaucoma model DBA\/2J","volume":"8","author":"Schnichels","year":"2007","journal-title":"Gene Expr. Patterns"},{"key":"2020030306395143100_ref54","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1442-9071.2009.02150.x","article-title":"Persistent hyperplastic primary vitreous: congenital malformation of the eye","volume":"37","author":"Shastry","year":"2009","journal-title":"Clin. Experiment. Ophthalmol."},{"key":"2020030306395143100_ref55","first-page":"1206","article-title":"Developmental mechanisms of congenital eye abnormalities","volume":"95","author":"Shirai","year":"1991","journal-title":"Nippon Ganka Gakkai Zasshi"},{"key":"2020030306395143100_ref56","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1167\/iovs.13-12706","article-title":"Formation of persistent hyperplastic primary vitreous in ephrin-A5\u2212\/\u2212 mice","volume":"55","author":"Son","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2020030306395143100_ref57","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1534-5807(03)00054-6","article-title":"Netrin-1\/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesis","volume":"4","author":"Srinivasan","year":"2003","journal-title":"Dev. Cell"},{"key":"2020030306395143100_ref58","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41419-017-0019-2","article-title":"Neogenin, a regulator of adult hippocampal neurogenesis, prevents depressive-like behavior","volume":"9","author":"Sun","year":"2018","journal-title":"Cell Death Dis."},{"key":"2020030306395143100_ref59","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1242\/dev.005520","article-title":"Physiological notch signaling promotes gliogenesis in the developing peripheral and central nervous systems","volume":"134","author":"Taylor","year":"2007","journal-title":"Development"},{"key":"2020030306395143100_ref60","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1242\/dev.012179","article-title":"Requirement for Foxd3 in the maintenance of neural crest progenitors","volume":"135","author":"Teng","year":"2008","journal-title":"Development"},{"key":"2020030306395143100_ref61","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1167\/iovs.06-0765","article-title":"Persistent hyperplastic primary vitreous due to somatic mosaic deletion of the arf tumor suppressor","volume":"48","author":"Thornton","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2020030306395143100_ref62","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.1242\/dev.099838","article-title":"The neogenin\/DCC homolog UNC-40 promotes BMP signaling via the RGM protein DRAG-1 in C. elegans","volume":"140","author":"Tian","year":"2013","journal-title":"Development"},{"key":"2020030306395143100_ref63","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1086\/383202","article-title":"Mutations in LRP5 or FZD4 underlie the common familial exudative vitreoretinopathy locus on chromosome 11q","volume":"74","author":"Toomes","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"2020030306395143100_ref64","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ydbio.2011.09.019","article-title":"Tfap2a and Foxd3 regulate early steps in the development of the neural crest progenitor population","volume":"360","author":"Wang","year":"2011","journal-title":"Dev. Biol."},{"key":"2020030306395143100_ref65","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.ydbio.2006.06.018","article-title":"Neogenin interacts with RGMa and netrin-1 to guide axons within the embryonic vertebrate forebrain","volume":"296","author":"Wilson","year":"2006","journal-title":"Dev. Biol."},{"key":"2020030306395143100_ref66","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1038\/ncb1321","article-title":"Phosphatidylinositol transfer protein-alpha in netrin-1-induced PLC signalling and neurite outgrowth","volume":"7","author":"Xie","year":"2005","journal-title":"Nat. Cell Biol."},{"key":"2020030306395143100_ref67","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1126\/science.1255149","article-title":"Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism","volume":"344","author":"Xu","year":"2014","journal-title":"Science"},{"key":"2020030306395143100_ref68","doi-asserted-by":"crossref","first-page":"5561","DOI":"10.1167\/iovs.08-2226","article-title":"A nonautonomous role for retinal frizzled-5 in regulating hyaloid vitreous vasculature development","volume":"49","author":"Zhang","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2020030306395143100_ref69","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.devcel.2010.06.016","article-title":"Neogenin regulation of BMP-induced canonical Smad signaling and endochondral bone formation","volume":"19","author":"Zhou","year":"2010","journal-title":"Dev. Cell"},{"key":"2020030306395143100_ref70","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1006\/exer.1998.0632","article-title":"The human hyaloid system: cellular phenotypes and inter-relationships","volume":"68","author":"Zhu","year":"1999","journal-title":"Exp. Eye Res."}],"container-title":["Journal of Molecular Cell Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jmcb\/advance-article-pdf\/doi\/10.1093\/jmcb\/mjz076\/28992868\/mjz076.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jmcb\/article-pdf\/12\/1\/17\/32757274\/mjz076.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jmcb\/article-pdf\/12\/1\/17\/32757274\/mjz076.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,23]],"date-time":"2022-09-23T06:09:34Z","timestamp":1663913374000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jmcb\/article\/12\/1\/17\/5537556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,23]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,7,23]]},"published-print":{"date-parts":[[2020,1,22]]}},"URL":"https:\/\/doi.org\/10.1093\/jmcb\/mjz076","relation":{},"ISSN":["1759-4685"],"issn-type":[{"type":"electronic","value":"1759-4685"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,7,23]]}}}