{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:41:07Z","timestamp":1792654867670,"version":"4.5.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,7,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We conducted a molecular survey of Rickettsia in fleas collected from opossums, road-killed and live-trapped in peridomestic and rural settings, state parks, and from pet cats and dogs in Georgia, United States during 1992\u20132014. The cat flea, Ctenocephalides felis (Bouch\u00e9) was the predominant species collected from cats and among the archival specimens from opossums found in peridomestic settings. Polygenis gwyni (Fox) was more prevalent on opossums and a single cotton rat trapped in sylvatic settings. Trapped animals were infested infrequently with the squirrel flea, Orchopeas howardi (Baker) and C. felis. TaqMan assays targeting the BioB gene of Rickettsia felis and the OmpB gene of Rickettsia typhi were used to test 291 flea DNAs for Rickettsia. A subset of 53 C. felis collected from a cat in 2011 was tested in 18 pools which were all bioB TaqMan positive (34% minimum infection prevalence). Of 238 fleas tested individually, 140 (58.8%, 95% confidence interval [CI]: 52.5\u201364.9%) DNAs were bioB positive. Detection of bioB was more prevalent in individual C. felis (91%) compared to P. gwyni (13.4%). Twenty-one (7.2%) were ompB TaqMan positive, including 18 C. felis (9.5%) and 3 P. gwyni (3.2%). Most of these fleas were also positive with bioB TaqMan; however, sequencing of gltA amplicons detected only DNA of Rickettsia asembonensis. Furthermore, only the R. asembonensis genotype was identified based on NlaIV restriction analysis of a larger ompB fragment. These findings contribute to understanding the diversity of Rickettsia associated with fleas in Georgia and emphasize the need for development of more specific molecular tools for detection and field research on rickettsial pathogens.<\/jats:p>","DOI":"10.1093\/jme\/tjaa029","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T03:29:54Z","timestamp":1583206194000},"page":"1246-1253","source":"Crossref","is-referenced-by-count":14,"title":["Detection of Rickettsia asembonensis in Fleas (Siphonaptera: Pulicidae, Ceratophyllidae) Collected in Five Counties in Georgia, United States"],"prefix":"10.1093","volume":"57","author":[{"given":"Marina E","family":"Eremeeva","sequence":"first","affiliation":[{"name":"Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Capps","sequence":"first","affiliation":[{"name":"Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA"},{"name":"Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia Logan","family":"McBride","sequence":"first","affiliation":[{"name":"Jiann-Ping Hsu College of Public Health, Georgia Southern University, Statesboro, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda J","family":"Williams-Newkirk","sequence":"first","affiliation":[{"name":"Environmental Sciences Department, Emory University, Atlanta, GA"},{"name":"Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, GA"},{"name":"Enteric Diseases Laboratory Branch, Centers for Disease Control and Prevention, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A","family":"Dasch","sequence":"first","affiliation":[{"name":"Rickettsial Zoonoses Branch, Centers for Disease Control and Prevention, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna S","family":"Salzer","sequence":"first","affiliation":[{"name":"Environmental Sciences Department, Emory University, Atlanta, GA"},{"name":"Poxvirus and Rabies Branch, Centers for Disease Control and Prevention, Atlanta, GA"},{"name":"Bacterial Special Pathogens Branch, Centers for Disease Control and Prevention, Atlanta, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenza","family":"Beati","sequence":"first","affiliation":[{"name":"U.S. National Tick Collection, Institute for Coastal Plain Science, Georgia Southern University, Statesboro, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance A","family":"Durden","sequence":"first","affiliation":[{"name":"College of Science and Mathematics, Georgia Southern University, Statesboro, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"2020070409344494900_CIT0001","doi-asserted-by":"crossref","first-page":"311","DOI":"10.4269\/ajtmh.1970.19.311","article-title":"The changing ecology of murine (endemic) typhus in Southern California","volume":"19","author":"Adams","year":"1970","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"2020070409344494900_CIT0002","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.pt.2016.04.009","article-title":"Rickettsia felis: the complex journey of an emergent human pathogen","volume":"32","author":"Angelakis","year":"2016","journal-title":"Trends Parasitol"},{"key":"2020070409344494900_CIT0003","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1146\/annurev.en.35.010190.003005","article-title":"Epidemiology of murine typhus","volume":"35","author":"Azad","year":"1990","journal-title":"Annu. Rev. Entomol"},{"key":"2020070409344494900_CIT0004","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3201\/eid0303.970308","article-title":"Flea-borne rickettsioses: ecologic considerations","volume":"3","author":"Azad","year":"1997","journal-title":"Emerg. Infect. Dis"},{"key":"2020070409344494900_CIT0005","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1128\/AEM.62.10.3914-3914.1996","article-title":"Genotype characterization of the bacterium expressing the male-killing trait in the ladybird beetle Adalia bipunctata with specific rickettsial molecular tools","volume":"62","author":"Balayeva","year":"1996","journal-title":"Appl. Environ. Microbiol"},{"key":"2020070409344494900_CIT0006","doi-asserted-by":"crossref","first-page":"134601","DOI":"10.1155\/2012\/134601","article-title":"Murine typhus: an important consideration for the nonspecific febrile illness","volume":"2012","author":"Basra","year":"2012","journal-title":"Case Rep. Med"},{"key":"2020070409344494900_CIT0007","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1645\/0022-3395(2001)087[0032:AOTSRA]2.0.CO;2","article-title":"Analysis of the systematic relationships among ticks of the genera Rhipicephalus and Boophilus (Acari: Ixodidae) based on mitochondrial 12S ribosomal DNA gene sequences and morphological characters","volume":"87","author":"Beati","year":"2001","journal-title":"J. Parasitol"},{"key":"2020070409344494900_CIT0008","volume-title":"An illustrated guide to the fleas of the eastern United States. Bioguide No. 3","author":"Benton","year":"1983"},{"key":"2020070409344494900_CIT0009","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1089\/vbz.2015.1869","article-title":"Detection of Rickettsia species in fleas collected from cats in regions endemic and nonendemic for flea-borne rickettsioses in California","volume":"16","author":"Billeter","year":"2016","journal-title":"Vector Borne Zoonotic Dis"},{"key":"2020070409344494900_CIT0010","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.4269\/ajtmh.15-0380","article-title":"An unusual cutaneous manifestation in a patient with murine typhus","volume":"93","author":"Blanton","year":"2015","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"2020070409344494900_CIT0011","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4269\/ajtmh.16-0197","article-title":"Opossums and cat fleas: new insights in the ecology of murine typhus in Galveston, Texas","volume":"95","author":"Blanton","year":"2016","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"2020070409344494900_CIT0012","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1089\/vbz.2018.2428","article-title":"Differentiation of Rickettsia felis and Rickettsia felis-like organisms via restriction fragment length polymorphism analysis","volume":"19","author":"Blanton","year":"2019","journal-title":"Vector Borne Zoonotic Dis"},{"key":"2020070409344494900_CIT0013","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1089\/vbz.2018.2402","article-title":"Rickettsiae within the fleas of feral cats in Galveston, Texas","volume":"19","author":"Blanton","year":"2019","journal-title":"Vector Borne Zoonotic Dis"},{"key":"2020070409344494900_CIT0014","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1099\/00207713-51-2-339","article-title":"Rickettsia felis: molecular characterization of a new member of the spotted fever group","volume":"51","author":"Bouyer","year":"2001","journal-title":"Int. J. Syst. Evol. Microbiol"},{"key":"2020070409344494900_CIT0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s40475-016-0070-6","article-title":"Rickettsia felis, an emerging flea-borne rickettsiosis","volume":"3","author":"Brown","year":"2016","journal-title":"Curr. Trop. Med. Rep"},{"key":"2020070409344494900_CIT0016","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1086\/527443","article-title":"Murine typhus: an unrecognized suburban vectorborne disease","volume":"46","author":"Civen","year":"2008","journal-title":"Clin. Infect. Dis"},{"key":"2020070409344494900_CIT0017","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1001\/jama.1991.03470100057033","article-title":"Clinical and laboratory features of murine typhus in south Texas, 1980 through 1987","volume":"266","author":"Dumler","year":"1991","journal-title":"JAMA"},{"key":"2020070409344494900_CIT0018","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2992\/007.080.0201","article-title":"The flea (Siphonaptera) fauna of Georgia, U.S.A.: hosts, distribution and medical-veterinary importance","volume":"80","author":"Durden","year":"2012","journal-title":"Ann. Carnegie Mus"},{"key":"2020070409344494900_CIT0019","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1128\/JCM.32.3.803-810.1994","article-title":"Differentiation among spotted fever group rickettsiae species by analysis of restriction fragment length polymorphism of PCR-amplified DNA","volume":"32","author":"Eremeeva","year":"1994","journal-title":"J. Clin. Microbiol"},{"key":"2020070409344494900_CIT0020","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1128\/JCM.41.12.5466-5472.2003","article-title":"Evaluation of a PCR assay for quantitation of Rickettsia rickettsii and closely related spotted fever group rickettsiae","volume":"41","author":"Eremeeva","year":"2003","journal-title":"J. Clin. Microbiol"},{"key":"2020070409344494900_CIT0021","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3201\/eid1410.080571","article-title":"Rickettsia typhi and R. felis in rat fleas (Xenopsylla cheopis), Oahu, Hawaii","volume":"14","author":"Eremeeva","year":"2008","journal-title":"Emerg. Infect. Dis"},{"key":"2020070409344494900_CIT0022","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1603\/ME11291","article-title":"Two pathogens and one disease: detection and identification of flea-borne rickettsiae in areas endemic for murine typhus in California","volume":"49","author":"Eremeeva","year":"2012","journal-title":"J. Med. Entomol"},{"key":"2020070409344494900_CIT0023","volume-title":"Fleas of eastern United States","author":"Fox","year":"1968"},{"key":"2020070409344494900_CIT0024","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/S0035-9203(02)90090-8","article-title":"Murine typhus in Greece: epidemiological, clinical, and therapeutic data from 83 cases","volume":"96","author":"Gikas","year":"2002","journal-title":"Trans. R. Soc. Trop. Med. Hyg"},{"key":"2020070409344494900_CIT0025","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.mcp.2006.06.002","article-title":"Development of quantitative real-time PCR assays to detect Rickettsia typhi and Rickettsia felis, the causative agents of murine typhus and flea-borne spotted fever","volume":"21","author":"Henry","year":"2007","journal-title":"Mol. Cell. Probes"},{"key":"2020070409344494900_CIT0026","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2583.1994.tb00147.x","article-title":"Molecular identification of rickettsia-like microorganisms associated with colonized cat fleas (Ctenocephalides felis)","volume":"3","author":"Higgins","year":"1994","journal-title":"Insect Mol. Biol"},{"key":"2020070409344494900_CIT0027","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1136\/bjo.2008.156059","article-title":"Ocular manifestations associated with murine typhus","volume":"93","author":"Khairallah","year":"2009","journal-title":"Br. J. Ophthalmol"},{"key":"2020070409344494900_CIT0028","doi-asserted-by":"crossref","first-page":"429","DOI":"10.2307\/4590821","article-title":"Murine typhus investigations in southwestern Georgia","volume":"75","author":"Love","year":"1960","journal-title":"Public Health Rep"},{"key":"2020070409344494900_CIT0029","doi-asserted-by":"crossref","first-page":"931","DOI":"10.3201\/eid2405.170323","article-title":"Rickettsia asembonensis characterization by multilocus sequence typing of complete genes, Peru","volume":"24","author":"Loyola","year":"2018","journal-title":"Emerg. Infect. Dis"},{"key":"2020070409344494900_CIT0030","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3201\/eid1802.111372","article-title":"Rickettsia felis infection in febrile patients, western Kenya, 2007\u20132010","volume":"18","author":"Maina","year":"2012","journal-title":"Emerg. Infect. Dis"},{"key":"2020070409344494900_CIT0031","doi-asserted-by":"crossref","first-page":"e0160604","DOI":"10.1371\/journal.pone.0160604","article-title":"Rickettsial infections among Ctenocephalides felis and host animals during a flea-borne rickettsioses outbreak in Orange County, California","volume":"11","author":"Maina","year":"2016","journal-title":"PLoS One"},{"key":"2020070409344494900_CIT0032","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3389\/fvets.2018.00334","article-title":"Worldwide presence and features of flea-borne Rickettsia asembonensis","volume":"5","author":"Maina","year":"2018","journal-title":"Front. Vet. Sci"},{"key":"2020070409344494900_CIT0033","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.3201\/eid1911.130361","article-title":"Common epidemiology of Rickettsia felis infection and malaria, Africa","volume":"19","author":"Mediannikov","year":"2013","journal-title":"Emerg. Infect. Dis"},{"key":"2020070409344494900_CIT0034","first-page":"255","article-title":"Eradication of murine typhus fever in a rural area: preliminary report","volume":"16","author":"Mohr","year":"1957","journal-title":"Bull. World Health Org"},{"key":"2020070409344494900_CIT0035","doi-asserted-by":"crossref","first-page":"645","DOI":"10.3201\/eid2304.160958","article-title":"Typhus group rickettsiosis, Texas, USA, 2003\u20132013","volume":"23","author":"Murray","year":"2017","journal-title":"Emerg. Infect. Dis"},{"key":"2020070409344494900_CIT0036","doi-asserted-by":"crossref","first-page":"e0006385","DOI":"10.1371\/journal.pntd.0006385","article-title":"A 2015 outbreak of flea-borne rickettsiosis in San Gabriel Valley, Los Angeles County, California","volume":"12","author":"Nelson","year":"2018","journal-title":"Plos Negl. Trop. Dis"},{"key":"2020070409344494900_CIT0037","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1002\/(SICI)1097-0258(19981130)17:22<2635::AID-SIM954>3.0.CO;2-C","article-title":"Improved confidence intervals for the difference between binomial proportions based on paired data","volume":"17","author":"Newcombe","year":"1998","journal-title":"Stat. Med"},{"key":"2020070409344494900_CIT0038","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/jme\/tjx069","article-title":"First detection of Rickettsia typhi and Rickettsia felis in fleas collected from client-owned companion animals in the southern Great Plains","volume":"54","author":"Noden","year":"2017","journal-title":"J. Med. Entomol"},{"key":"2020070409344494900_CIT0039","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.vetmic.2012.11.043","article-title":"The role of dogs in the eco-epidemiology of Rickettsia typhi, etiological agent of Murine typhus","volume":"163","author":"Nogueras","year":"2013","journal-title":"Vet. Microbiol"},{"key":"2020070409344494900_CIT0040","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1097\/00007611-191301000-00018","article-title":"Typhus fever with a report of cases","volume":"6","author":"Paullin","year":"1913","journal-title":"South. Med. J"},{"key":"2020070409344494900_CIT0041","first-page":"310","article-title":"Bartonella and Rickettsia in fleas and lice from mammals in South Carolina, U.S.A","volume":"30","author":"Reeves","year":"2005","journal-title":"J. Vector Ecol"},{"key":"2020070409344494900_CIT0042","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1603\/033.046.0402","article-title":"Ecology of Rickettsia felis: a review","volume":"46","author":"Reif","year":"2009","journal-title":"J. Med. Entomol"},{"key":"2020070409344494900_CIT0043","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1574-695X.2011.00875.x","article-title":"Worldwide detection and identification of new and old rickettsiae and rickettsial diseases","volume":"64","author":"Richards","year":"2012","journal-title":"FEMS Immunol. Med. Microbiol"},{"key":"2020070409344494900_CIT0044","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1099\/00207713-50-4-1449","article-title":"Phylogenetic analysis of members of the genus Rickettsia using the gene encoding the outer-membrane protein rOmpB (ompB)","volume":"50 Pt 4","author":"Roux","year":"2000","journal-title":"Int. J. Syst. Evol. Microbiol"},{"key":"2020070409344494900_CIT0045","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/j.1708-8305.2012.00678.x","article-title":"Severe murine typhus with shock and acute respiratory failure in a Japanese traveler after returning from Thailand","volume":"20","author":"Sakamoto","year":"2013","journal-title":"J. Travel Med"},{"key":"2020070409344494900_CIT0046","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1089\/vbz.2016.2049","article-title":"Survey for rickettsiae within fleas of great gerbils, Almaty Oblast, Kazakhstan","volume":"17","author":"Sansyzbayev","year":"2017","journal-title":"Vector Borne Zoonotic Dis"},{"key":"2020070409344494900_CIT0047","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1128\/JCM.32.4.949-954.1994","article-title":"Identification of a novel rickettsial infection in a patient diagnosed with murine typhus","volume":"32","author":"Schriefer","year":"1994","journal-title":"J. Clin. Microbiol"},{"key":"2020070409344494900_CIT0048","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/jmedent\/31.5.681","article-title":"Murine typhus: updated roles of multiple urban components and a second typhuslike rickettsia","volume":"31","author":"Schriefer","year":"1994","journal-title":"J. Med. Entomol"},{"key":"2020070409344494900_CIT0049","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.actatropica.2017.04.004","article-title":"First report of a Rickettsia asembonensis related infecting fleas in Brazil","volume":"172","author":"Silva","year":"2017","journal-title":"Acta Trop"},{"key":"2020070409344494900_CIT0050","first-page":"36","article-title":"Molecular identity of cat fleas (Ctenocephalides felis) from cats in Georgia, USA carrying Bartonella clarridgeiae, Bartonella henselae and Rickettsia sp. RF2125","volume":"3\u20134","author":"Slapeta","year":"2016","journal-title":"Vet. Parasitol. Reg. Stud. Reports"},{"key":"2020070409344494900_CIT0051","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.3201\/eid1607.100070","article-title":"Rickettsia felis-associated uneruptive fever, Senegal","volume":"16","author":"Socolovschi","year":"2010","journal-title":"Emerg. Infect. Dis"},{"key":"2020070409344494900_CIT0052","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4269\/ajtmh.1993.48.269","article-title":"A suburban focus of endemic typhus in Los Angeles County: association with seropositive domestic cats and opossums","volume":"48","author":"Sorvillo","year":"1993","journal-title":"Am. J. Trop. Med. Hyg"},{"key":"2020070409344494900_CIT0053","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1093\/ajcp\/91.6.720","article-title":"Histopathology and immunohistologic demonstration of the distribution of Rickettsia typhi in fatal murine typhus","volume":"91","author":"Walker","year":"1989","journal-title":"Am. J. Clin. Pathol"},{"key":"2020070409344494900_CIT0054","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1128\/JCM.30.7.1758-1762.1992","article-title":"Typhus and typhuslike rickettsiae associated with opossums and their fleas in Los Angeles County, California","volume":"30","author":"Williams","year":"1992","journal-title":"J. Clin. Microbiol"}],"container-title":["Journal of Medical Entomology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jme\/article-pdf\/57\/4\/1246\/33463510\/tjaa029.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jme\/article-pdf\/57\/4\/1246\/33463510\/tjaa029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T13:36:18Z","timestamp":1593869778000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jme\/article\/57\/4\/1246\/5771513"}},"subtitle":[],"editor":[{"given":"Janet","family":"Foley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,3]]},"references-count":54,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,3,3]]},"published-print":{"date-parts":[[2020,7,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jme\/tjaa029","relation":{},"ISSN":["0022-2585","1938-2928"],"issn-type":[{"value":"0022-2585","type":"print"},{"value":"1938-2928","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,7]]},"published":{"date-parts":[[2020,3,3]]}}}