{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:06:31Z","timestamp":1792785991421,"version":"4.5.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T00:00:00Z","timestamp":1634601600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX10101002-002"],"award-info":[{"award-number":["2018ZX10101002-002"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX10712001-006-002"],"award-info":[{"award-number":["2018ZX10712001-006-002"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX10732401-001"],"award-info":[{"award-number":["2018ZX10732401-001"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Inner Mongolia Natural Science Foundation Project","award":["2016MS0859"],"award-info":[{"award-number":["2016MS0859"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102390"],"award-info":[{"award-number":["82102390"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Key Scientific Technology Project of Inner Mongolia Autonomous Region","award":["2021ZD0006"],"award-info":[{"award-number":["2021ZD0006"]}]},{"name":"Medical Youth Top Talent Project of Hubei"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Mosquitoes are the most important vectors carrying significant numbers of human pathogens. Recent studies implicated that mosquitoes play an important role in circulation and transmission of multiple Rickettsia species. In this study, Rickettsia bellii was identified in four mosquito species (Culex pipiens, C. tritaeniorhynchus, Aedes albopictus, and Anopheles sinensis) collected from three Eastern China provinces during 2019\u20132020. Rickettsia bellii was detected in 37.50 and 26.32% of the C. pipiens pools from Beijing and Jiangsu province, respectively. In C. tritaeniorhynchus and An. sinensis from Shandong, the infection rate is 20.00 and 6.25%, respectively. Additionally, three Ae. albopictus pools (3\/42, 7.14%) from Beijing were also detected positive for R. bellii. Genetic and phylogenetic analysis on 16S, gltA, and groEL genes indicates that sequences from all these strains are highly homologous and closely related to other R. bellii strains. This is the first report that Ae. albopictus and C. tritaeniorhynchus harbor R. bellii. The wide host range and high infection rate in certain areas may dramatically increase the exposure of R. bellii to human and other vertebrates. The role of mosquitoes in transmission of rickettsiosis and its potential risk to public health should be further considered.<\/jats:p>","DOI":"10.1093\/jme\/tjab177","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T19:28:15Z","timestamp":1634758095000},"page":"390-393","source":"Crossref","is-referenced-by-count":3,"title":["High Prevalence of\n                    <i>Rickettsia bellii<\/i>\n                    in Mosquitoes From Eastern China"],"prefix":"10.1093","volume":"59","author":[{"given":"Feng","family":"Li","sequence":"first","affiliation":[{"name":"Yancheng Center for Disease Control and Prevention, Yancheng City, Jiangsu Province 224000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhua","family":"Tian","sequence":"additional","affiliation":[{"name":"Wuhan Center for Disease Control and Prevention, Wuhan City, Hubei Province 430024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[{"name":"Laoshan No. 3 Middle School, Qingdao City, Shandong Province 266061, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengpei","family":"Yang","sequence":"additional","affiliation":[{"name":"Liping Center for Disease Control and Prevention, Southeast Guizhou Miao-Dong Autonomous Prefecture, Guizhou Province 557300, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing City 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xincheng","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing City 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqing","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing City 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jintao","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Basic Medical Sciences, Wuhan University, Wuhan City, Hubei Province 430071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5316-2703","authenticated-orcid":false,"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Zoonoses, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Changping District, Beijing City 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,19]]},"reference":[{"key":"2022011306522817900_CIT0001","doi-asserted-by":"crossref","first-page":"18823","DOI":"10.1038\/s41598-020-74883-3","article-title":"Culicidae evolutionary history focusing on the Culicinae subfamily based on mitochondrial phylogenomics","volume":"10","author":"da Silva","year":"2020","journal-title":"Sci. Rep"},{"key":"2022011306522817900_CIT0002","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/1756-3305-7-191","article-title":"Rickettsia bellii, Rickettsia amblyommii, and Laguna Negra hantavirus in an Indian reserve in the Brazilian Amazon","volume":"7","author":"de Barros Lopes","year":"2014","journal-title":"Parasit. Vectors"},{"key":"2022011306522817900_CIT0003","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s10493-019-00397-x","article-title":"Serologic and molecular survey of Rickettsia spp. in dogs, horses and ticks from the Atlantic rainforest of the state of Bahia, Brazil","volume":"78","author":"de Oliveira","year":"2019","journal-title":"Exp. Appl. Acarol"},{"key":"2022011306522817900_CIT0004","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1179\/2047773212Y.0000000022","article-title":"Rickettsia bellii infecting Amblyomma sabanerae ticks in El Salvador","volume":"106","author":"Barbieri","year":"2012","journal-title":"Pathog. Glob. Health"},{"key":"2022011306522817900_CIT0005","doi-asserted-by":"crossref","first-page":"8088","DOI":"10.1073\/pnas.1413835112","article-title":"Transmission potential of Rickettsia felis infection by Anopheles gambiae mosquitoes","volume":"112","author":"Dieme","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2022011306522817900_CIT0006","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-59745-251-9_6","article-title":"Estimating maximum likelihood phylogenies with PhyML","volume":"537","author":"Guindon","year":"2009","journal-title":"Methods Mol. Biol"},{"key":"2022011306522817900_CIT0007","doi-asserted-by":"crossref","first-page":"38770","DOI":"10.1038\/srep38770","article-title":"Extensive genetic diversity of Rickettsiales bacteria in multiple mosquito species","volume":"6","author":"Guo","year":"2016","journal-title":"Sci. Rep"},{"key":"2022011306522817900_CIT0008","doi-asserted-by":"crossref","first-page":"103927","DOI":"10.1016\/j.meegid.2019.103927","article-title":"GroEL gene typing and genetic diversity of Anaplasma bovis in ticks in Shaanxi, China","volume":"74","author":"Guo","year":"2019","journal-title":"Infect. Genet. Evol"},{"key":"2022011306522817900_CIT0009","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/B978-0-12-800172-1.00005-7","article-title":"Arboviruses pathogenic for domestic and wild animals","volume":"89","author":"Hub\u00e1lek","year":"2014","journal-title":"Adv. Virus Res"},{"key":"2022011306522817900_CIT0010","doi-asserted-by":"crossref","first-page":"e0007405","DOI":"10.1371\/journal.pntd.0007405","article-title":"Ticks and serosurvey of anti-Rickettsia spp. antibodies in wild boars (Sus scrofa), hunting dogs and hunters of Brazil","volume":"13","author":"Kmetiuk","year":"2019","journal-title":"PLoS Negl. Trop. Dis"},{"key":"2022011306522817900_CIT0011","doi-asserted-by":"crossref","first-page":"8505483","DOI":"10.1155\/2018\/8505483","article-title":"Genotypic characterization of Rickettsia bellii reveals distinct lineages in the United States and South America","volume":"2018","author":"Krawczak","year":"2018","journal-title":"Biomed. Res. Int"},{"key":"2022011306522817900_CIT0012","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s00248-006-9180-3","article-title":"Infection by Rickettsia bellii and Candidatus \u201cRickettsia amblyommii\u201d in Amblyomma neumanni ticks from Argentina","volume":"54","author":"Labruna","year":"2007","journal-title":"Microb. Ecol"},{"key":"2022011306522817900_CIT0013","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.pop.2018.05.001","article-title":"Mosquito-Borne Diseases","volume":"45","author":"Lee","year":"2018","journal-title":"Prim. Care"},{"key":"2022011306522817900_CIT0014","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1603\/0022-2585-39.6.809","article-title":"Rickettsial infection in Dermacentor variabilis (Acari: Ixodidae) inhibits transovarial transmission of a second Rickettsia","volume":"39","author":"Macaluso","year":"2002","journal-title":"J. Med. Entomol"},{"key":"2022011306522817900_CIT0015","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1590\/S1517-838246320140623","article-title":"Detection of Rickettsia bellii and Rickettsia amblyommii in Amblyomma longirostre (Acari: Ixodidae) from Bahia state, Northeast Brazil","volume":"46","author":"McIntosh","year":"2015","journal-title":"Braz. J. Microbiol"},{"key":"2022011306522817900_CIT0016","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ttbdis.2013.10.008","article-title":"Molecular detection of Rickettsia bellii and Rickettsia sp. strain colombianensi in ticks from Cordoba, Colombia","volume":"5","author":"Miranda","year":"2014","journal-title":"Ticks Tick. Borne. Dis"},{"key":"2022011306522817900_CIT0017","doi-asserted-by":"crossref","first-page":"e021419","DOI":"10.1590\/s1984-29612020018","article-title":"Serosurvey on rickettsiae of the spotted fever group and Rickettsia bellii among dogs in the state of Goi\u00e1s, Brazil","volume":"29","author":"Neves","year":"2020","journal-title":"Rev. Bras. Parasitol. Vet"},{"key":"2022011306522817900_CIT0018","doi-asserted-by":"crossref","first-page":"e76","DOI":"10.1371\/journal.pgen.0020076","article-title":"Genome sequence of Rickettsia bellii illuminates the role of amoebae in gene exchanges between intracellular pathogens","volume":"2","author":"Ogata","year":"2006","journal-title":"PLoS Genet"},{"key":"2022011306522817900_CIT0019","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.ttbdis.2012.05.003","article-title":"Rickettsia bellii in ticks Amblyomma varium Koch, 1844, from birds in Peru","volume":"3","author":"Ogrzewalska","year":"2012","journal-title":"Ticks Tick Borne. Dis"},{"key":"2022011306522817900_CIT0020","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/CMR.00032-13","article-title":"Update on tick-borne rickettsioses around the world: a geographic approach","volume":"26","author":"Parola","year":"2013","journal-title":"Clin. Microbiol. Rev"},{"key":"2022011306522817900_CIT0021","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1099\/00207713-33-1-94","article-title":"Rickettsia bellii sp. nov.: a tick-borne Rickettsia, widely distributed in the United States, that is distinct from the spotted fever and typhus biogroups","volume":"33","author":"Philip","year":"1983","journal-title":"Int. J. Syst. Bacteriol"},{"key":"2022011306522817900_CIT0022","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s10493-014-9851-6","article-title":"Ticks and rickettsial infection in the wildlife of two regions of the Brazilian Amazon","volume":"65","author":"Soares","year":"2015","journal-title":"Exp. Appl. Acarol"},{"key":"2022011306522817900_CIT0023","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.3201\/eid1810.120178","article-title":"Rickettsia felis in Aedes albopictus mosquitoes, Libreville, Gabon","volume":"18","author":"Socolovschi","year":"2012","journal-title":"Emerg. Infect. Dis"},{"key":"2022011306522817900_CIT0024","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13071-017-2601-y","article-title":"Genotype and biotype of invasive Anopheles stephensi in Mannar Island of Sri Lanka","volume":"11","author":"Surendran","year":"2018","journal-title":"Parasit. Vectors"},{"key":"2022011306522817900_CIT0025","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"MEGA6: Molecular Evolutionary Genetics Analysis version 6.0","volume":"30","author":"Tamura","year":"2013","journal-title":"Mol. Biol. Evol"},{"key":"2022011306522817900_CIT0026","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1741-7007-7-6","article-title":"Evolution and diversity of Rickettsia bacteria","volume":"7","author":"Weinert","year":"2009","journal-title":"BMC Biol"},{"key":"2022011306522817900_CIT0027","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1089\/vbz.2019.2456","article-title":"Molecular detection of Rickettsia felis and Rickettsia bellii in mosquitoes","volume":"19","author":"Zhang","year":"2019","journal-title":"Vector Borne Zoonotic Dis"}],"container-title":["Journal of Medical Entomology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jme\/article-pdf\/59\/1\/390\/41961564\/tjab177.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jme\/article-pdf\/59\/1\/390\/41961564\/tjab177.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,13]],"date-time":"2022-01-13T01:54:39Z","timestamp":1642038879000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jme\/article\/59\/1\/390\/6402718"}},"subtitle":[],"editor":[{"given":"Kevin","family":"Macaluso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,10,19]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,10,19]]},"published-print":{"date-parts":[[2022,1,12]]}},"URL":"https:\/\/doi.org\/10.1093\/jme\/tjab177","relation":{},"ISSN":["0022-2585","1938-2928"],"issn-type":[{"value":"0022-2585","type":"print"},{"value":"1938-2928","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,1]]},"published":{"date-parts":[[2021,10,19]]}}}