{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:42:37Z","timestamp":1793331757841,"version":"4.5.0"},"reference-count":94,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/501100005242","name":"Universit\u00e9 de Montr\u00e9al","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005242","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012016","name":"Institut national de sant\u00e9 publique du Qu\u00e9bec","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["03793-2014"],"award-info":[{"award-number":["03793-2014"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,11,16]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The development of interventions that reduce Lyme disease incidence remains a challenge. Reservoir-targeted approaches aiming to reduce tick densities or tick infection prevalence with Borrelia burgdorferi have emerged as promising ways to reduce the density of infected ticks. Acaricides of the isoxazoline family offer high potential for reducing infestation of ticks on small mammals as they have high efficacy at killing feeding ticks for a long period. Fluralaner baits were recently demonstrated as effective, in the laboratory, at killing Ixodes scapularis larvae infesting Peromyscus mice, the main reservoir for B. burgdorferi in northeastern North America. Here, effectiveness of this approach for reducing the infestation of small mammals by immature stages of I. scapularis was tested in a natural environment. Two densities of fluralaner baits (2.1 baits\/1,000 m2 and 4.4 baits\/1,000 m2) were used during three years in forest plots. The number of I. scapularis larvae and nymphs per mouse from treated and control plots were compared. Fluralaner baiting reduced the number of larvae per mouse by 68% (CI95: 51\u201379%) at 2.1 baits\/1,000 m2 and by 86% (CI95: 77\u201392%) at 4.4 baits\/1,000 m2. The number of nymphs per mouse was reduced by 72% (CI95: 22\u201390%) at 4.4 baits\/1,000 m2 but was not significantly reduced at 2.1 baits\/1,000 m2. Reduction of Peromyscus mouse infestation by immature stages of I. scapularis supports the hypothesis that an approach targeting reservoirs of B. burgdorferi with isoxazolines has the potential to reduce tick-borne disease risk by decreasing the density of infected ticks in the environment.<\/jats:p>","DOI":"10.1093\/jme\/tjac106","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T15:17:59Z","timestamp":1660835879000},"page":"2080-2089","source":"Crossref","is-referenced-by-count":16,"title":["Fluralaner Baits Reduce the Infestation of Peromyscus spp. Mice (Rodentia: Cricetidae) by Ixodes scapularis (Acari: Ixodidae) Larvae and Nymphs in a Natural Environment"],"prefix":"10.1093","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-5446","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Pelletier","sequence":"first","affiliation":[{"name":"D\u00e9partement de pathologie et microbiologie, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"Groupe de recherche en \u00e9pid\u00e9miologie des zoonoses et sant\u00e9 publique, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"Centre de recherche en sant\u00e9 publique de l\u2019Universit\u00e9 de Montr\u00e9al et du CIUSSS du Centre-Sud-de-l\u2019\u00cele-de-Montr\u00e9al , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Philippe","family":"Rocheleau","sequence":"additional","affiliation":[{"name":"Groupe de recherche en \u00e9pid\u00e9miologie des zoonoses et sant\u00e9 publique, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"D\u00e9partement de sant\u00e9 animale, C\u00c9GEP de Saint-Hyacinthe , Saint-Hyacinthe, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Aenishaenslin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et microbiologie, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"Groupe de recherche en \u00e9pid\u00e9miologie des zoonoses et sant\u00e9 publique, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"Centre de recherche en sant\u00e9 publique de l\u2019Universit\u00e9 de Montr\u00e9al et du CIUSSS du Centre-Sud-de-l\u2019\u00cele-de-Montr\u00e9al , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle","family":"Dimitri Masson","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et microbiologie, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"Groupe de recherche en \u00e9pid\u00e9miologie des zoonoses et sant\u00e9 publique, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L Robbin","family":"Lindsay","sequence":"additional","affiliation":[{"name":"One Health Division, National Microbiology Laboratory, Public Health Agency of Canada , Winnipeg, Manitoba , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas H","family":"Ogden","sequence":"additional","affiliation":[{"name":"Groupe de recherche en \u00e9pid\u00e9miologie des zoonoses et sant\u00e9 publique, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada , Saint-Hyacinthe, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Groupe de recherche en \u00e9pid\u00e9miologie des zoonoses et sant\u00e9 publique, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"Public Health Risk Sciences Division, National Microbiology Laboratory, Public Health Agency of Canada , Saint-Hyacinthe, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick A","family":"Leighton","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et microbiologie, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"Groupe de recherche en \u00e9pid\u00e9miologie des zoonoses et sant\u00e9 publique, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec , Canada"},{"name":"Centre de recherche en sant\u00e9 publique de l\u2019Universit\u00e9 de Montr\u00e9al et du CIUSSS du Centre-Sud-de-l\u2019\u00cele-de-Montr\u00e9al , Montr\u00e9al, Qu\u00e9bec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"2022111613192792700_CIT0001","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1186\/s12889-022-13222-9","article-title":"Behavioral risk factors associated with tick exposure in a Lyme disease high incidence region in Canada","volume":"22","author":"Aenishaenslin","year":"2022","journal-title":"BMC Public Health"},{"key":"2022111613192792700_CIT0002","volume-title":"D\u00e9veloppement et \u00e9valuation d\u2019une intervention Une seule sant\u00e9 pour r\u00e9duire le risque de maladie de Lyme \u00e0 Bromont - 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