{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:59:26Z","timestamp":1792130366578,"version":"4.4.0"},"reference-count":181,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>La Crosse virus (LACV) is the most common cause of neuroinvasive mosquito-borne disease in children within the United States. Despite more than 50 years of recognized endemicity in the United States, the true burden of LACV disease is grossly underappreciated, and there remain severe knowledge gaps that inhibit public health interventions to reduce morbidity and mortality. Long-standing deficiencies in disease surveillance, clinical diagnostics and therapeutics, actionable entomologic and environmental risk indices, case response capacity, public awareness, and availability of community support groups clearly frame LACV disease as neglected. Here we synthesize salient prior research and contextualize our findings as an assessment of current gaps and opportunities to develop a framework to prevent, detect, and respond to LACV disease. The persistent burdens of LACV disease clearly require renewed public health attention, policy, and action.<\/jats:p>","DOI":"10.1093\/jme\/tjad090","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T18:15:46Z","timestamp":1697825746000},"page":"1165-1182","source":"Crossref","is-referenced-by-count":20,"title":["La Crosse virus neuroinvasive disease: the kids are not alright"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9898-6140","authenticated-orcid":false,"given":"Corey A","family":"Day","sequence":"first","affiliation":[{"name":"Entomology and Plant Pathology, University of Tennessee , Knoxville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9129-159X","authenticated-orcid":false,"given":"Brian D","family":"Byrd","sequence":"additional","affiliation":[{"name":"Environmental Health Sciences, Western Carolina University , Cullowhee, NC , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-0220","authenticated-orcid":false,"given":"Rebecca T","family":"Trout Fryxell","sequence":"additional","affiliation":[{"name":"Entomology and Plant Pathology, University of Tennessee , Knoxville, TN , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"2023111418461375500_CIT0001","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1089\/vbz.2011.0917","article-title":"Zoonotic infections among employees from Great Smoky Mountains and Rocky Mountain National Parks, 2008\u20132009","volume":"12","author":"Adjemian","year":"2012","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"3","key":"2023111418461375500_CIT0002","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4269\/ajtmh.1981.30.706","article-title":"Natural La Crosse virus infection in the red fox (Vulpes fulva), gray fox (Urocyon cinereoargenteus), raccoon (Procyon lotor), and opossum (Didelphis virginiana)","volume":"30","author":"Amundson","year":"1981","journal-title":"Am J Trop Med Hyg"},{"issue":"3","key":"2023111418461375500_CIT0003","doi-asserted-by":"crossref","first-page":"586","DOI":"10.4269\/ajtmh.1985.34.586","article-title":"Experimental La Crosse virus infection of red fox (Vulpes fulva), raccoon (Procyon lotor), opossum (Didelphis virginiana), and woodchuck (Marmota monax)","volume":"34","author":"Amundson","year":"1985","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"2023111418461375500_CIT0004","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1603\/0022-2585-38.6.774","article-title":"Discovery, distribution, and abundance of the newly introduced mosquito Ochlerotatus japonicus (Diptera: Culicidae) in Connecticut, USA","volume":"38","author":"Andreadis","year":"2001","journal-title":"J Med Entomol"},{"issue":"1","key":"2023111418461375500_CIT0005","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1603\/033.047.0106","article-title":"Evidence for reduction of native mosquitoes with increased expansion of invasive Ochlerotatus japonicus japonicus (Diptera: Culicidae) in the northeastern United States","volume":"47","author":"Andreadis","year":"2010","journal-title":"J Med Entomol"},{"key":"2023111418461375500_CIT0006","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1089\/153036604773083013","article-title":"Host feeding patterns of established and potential mosquito vectors of West Nile virus in the eastern United States","volume":"4","author":"Apperson","year":"2004","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"3","key":"2023111418461375500_CIT0007","doi-asserted-by":"crossref","first-page":"491","DOI":"10.4269\/ajtmh.2006.75.491","article-title":"A new genetic variant of La Crosse virus (bunyaviridae) isolated from New England","volume":"75","author":"Armstrong","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"2023111418461375500_CIT0008","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/infdis\/133.3.293","article-title":"California arbovirus (La Crosse) infections. 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