{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:18:24Z","timestamp":1791389904895,"version":"4.3.3"},"reference-count":53,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Colorado tick fever virus is an understudied tick-borne virus of medical importance that is primarily transmitted in the western United States and southwestern Canada. The virus is the type species of the genus Coltivirus (Spinareoviridae) and consists of 12 segments that remain largely uncharacterized. Patterns of viral distribution are driven by the presence of the primary vector, the Rocky Mountain wood tick, Dermacentor andersoni. Infection prevalence in D. andersoni can range from 3% to 58% across the geographic distribution of the tick. Infection in humans can be severe and often presents with fever relapses but is rarely fatal. Here, we review the literature from primary characterizations in the early 20th century to current virus\/vector research being conducted and identify vacancies in current research.<\/jats:p>","DOI":"10.1093\/jme\/tjad094","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T14:13:51Z","timestamp":1697811231000},"page":"1214-1220","source":"Crossref","is-referenced-by-count":19,"title":["Colorado tick fever virus: a review of historical literature and research emphasis for a modern era"],"prefix":"10.1093","volume":"60","author":[{"given":"Emma K","family":"Harris","sequence":"first","affiliation":[{"name":"Center for Vector-Borne Infectious Diseases, Colorado State University , Fort Collins, CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D","family":"Foy","sequence":"additional","affiliation":[{"name":"Center for Vector-Borne Infectious Diseases, Colorado State University , Fort Collins, CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4458-9959","authenticated-orcid":false,"given":"Gregory D","family":"Ebel","sequence":"additional","affiliation":[{"name":"Center for Vector-Borne Infectious Diseases, Colorado State University , Fort Collins, CO , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"2023111418455270500_CIT0001","doi-asserted-by":"crossref","first-page":"e13279","DOI":"10.7717\/peerj.13279","article-title":"Climate change influences on the geographic distributional potential of the spotted fever vectors Amblyomma maculatum and Dermacentor andersoni","volume":"10","author":"Alkishe","year":"2022","journal-title":"PeerJ"},{"issue":"3","key":"2023111418455270500_CIT0002","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1006\/bbrc.2000.3057","article-title":"Sequence determination and analysis of the full-length genome of Colorado tick fever virus, the type species of genus Coltivirus (Family Reoviridae)","volume":"273","author":"Attoui","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"2023111418455270500_CIT0003","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.3201\/eid1111.050868","article-title":"Coltiviruses and seadornaviruses in North America, Europe, and Asia","volume":"11","author":"Attoui","year":"2005","journal-title":"Emerg Infect Dis"},{"key":"2023111418455270500_CIT0004","first-page":"87","article-title":"Tick-borne infections in Colorado","volume":"27","author":"Becker","year":"1930","journal-title":"Colorado Med"},{"issue":"2","key":"2023111418455270500_CIT0005","doi-asserted-by":"crossref","first-page":"490","DOI":"10.4269\/ajtmh.1981.30.490","article-title":"The ecology of Colorado tick fever in Rocky Mountain National Park in 1974. II. Infection in small mammals","volume":"30","author":"Bowen","year":"1981","journal-title":"Am J Trop Med Hyg"},{"issue":"4","key":"2023111418455270500_CIT0006","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/vbz.2009.0065","article-title":"Epidemiology of Colorado tick fever in Montana, Utah, and Wyoming, 1995\u20132003","volume":"10","author":"Brackney","year":"2010","journal-title":"Vector Borne Zoonotic Dis"},{"key":"2023111418455270500_CIT0007","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1093\/infdis\/107.3.384","article-title":"Colorado tick fever. II. The behavior of Colorado tick fever virus in rodents","volume":"107","author":"Burgdorfer","year":"1960","journal-title":"J Infect Dis"},{"issue":"2","key":"2023111418455270500_CIT0008","first-page":"103","article-title":"Tick-borne diseases in the United States: Rocky Mountain spotted fever and Colorado tick fever. A review","volume":"34","author":"Burgdorfer","year":"1977","journal-title":"Acta Trop"},{"issue":"2","key":"2023111418455270500_CIT0009","first-page":"127","article-title":"Studies of the ecology of Colorado tick fever virus in Western Montana","volume":"69","author":"Burgdorfer","year":"1959","journal-title":"Am J Hyg"},{"issue":"2","key":"2023111418455270500_CIT0010","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3181\/00379727-64-15746","article-title":"Specific complement-fixing diagnostic antigens for Colorado tick fever","volume":"64","author":"DeBOER","year":"1947","journal-title":"Proc Soc Exp Biol Med"},{"issue":"9","key":"2023111418455270500_CIT0011","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.1172\/JCI44402","article-title":"Fitness and freezing: vector biology and human health","volume":"120","author":"Dumler","year":"2010","journal-title":"J Clin Invest"},{"issue":"4","key":"2023111418455270500_CIT0012","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/jmedent\/44.4.694","article-title":"Climate-based model predicting acarological risk of encountering the human-biting adult life stage of Dermacentor andersoni (Acari: Ixodidae) in a key habitat type in Colorado","volume":"44","author":"Eisen","year":"2007","journal-title":"J Med Entomol"},{"key":"2023111418455270500_CIT0013","first-page":"21","article-title":"Colorado tick fever","volume":"58","author":"Eklund","year":"1961","journal-title":"Rocky Mt Med J"},{"issue":"4","key":"2023111418455270500_CIT0014","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1001\/jama.1955.02950210031010","article-title":"Distribution of Colorado tick fever and virus-carrying ticks","volume":"157","author":"Eklund","year":"1955","journal-title":"J Am Med Assoc"},{"issue":"3321","key":"2023111418455270500_CIT0015","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1126\/science.128.3321.413.a","article-title":"Isolation of Colorado tick fever virus from rodents in Colorado","volume":"128","author":"Eklund","year":"1958","journal-title":"Science"},{"key":"2023111418455270500_CIT0016","volume-title":"Experimental Colorado tick fever infection in wild rodents: viremia and antibody response in active and hibernating animals","author":"Emmons","year":"1965"},{"key":"2023111418455270500_CIT0017","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1146\/annurev.mi.42.100188.000405","article-title":"Ecology of Colorado tick fever","volume":"42","author":"Emmons","year":"1988","journal-title":"Annu Rev Microbiol"},{"issue":"2","key":"2023111418455270500_CIT0018","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1099\/0022-1317-17-2-185","article-title":"Intra-erythrocytic location of Colorado tick fever virus","volume":"17","author":"Emmons","year":"1972","journal-title":"J Gen Virol"},{"issue":"2","key":"2023111418455270500_CIT0019","doi-asserted-by":"crossref","first-page":"211","DOI":"10.2105\/AJPH.38.2.211","article-title":"Epidemiology of Colorado tick fever","volume":"38","author":"Florio","year":"1948","journal-title":"Am J Public Health Nations Health"},{"issue":"4","key":"2023111418455270500_CIT0020","doi-asserted-by":"crossref","first-page":"257","DOI":"10.4049\/jimmunol.64.4.257","article-title":"Colorado tick fever; isolation of the virus from Dermacentar andersoni in nature and a laboratory study of the transmission of the virus in the tick","volume":"64","author":"Florio","year":"1950","journal-title":"J Immunol"},{"issue":"2","key":"2023111418455270500_CIT0021","first-page":"129","article-title":"The etiology of Colorado tick fever and an immunological comparison to dengue","volume":"44","author":"Florio","year":"1947","journal-title":"Rocky Mt Med J"},{"issue":"3","key":"2023111418455270500_CIT0022","doi-asserted-by":"crossref","first-page":"293","DOI":"10.2105\/AJPH.37.3.293","article-title":"Colorado tick fever","volume":"37","author":"Florio","year":"1947","journal-title":"Am J Public Health Nations Health"},{"issue":"3","key":"2023111418455270500_CIT0023","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1084\/jem.80.3.165","article-title":"The experimental transmission of Colorado tick fever","volume":"80","author":"Florio","year":"1944","journal-title":"J Exp Med"},{"key":"2023111418455270500_CIT0024","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.83.1.1","article-title":"The etiology of Colorado tick fever","volume":"83","author":"Florio","year":"1946","journal-title":"J Exp Med"},{"issue":"6","key":"2023111418455270500_CIT0025","doi-asserted-by":"crossref","first-page":"102036","DOI":"10.1016\/j.ttbdis.2022.102036","article-title":"Surveillance of Rocky Mountain wood ticks (Dermacentor andersoni) and American dog ticks (Dermacentor variabilis) in Colorado","volume":"13","author":"Freeman","year":"2022","journal-title":"Ticks Tick Borne Dis"},{"key":"2023111418455270500_CIT0026","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.virusres.2017.09.017","article-title":"Isolation and characterization of Tarumizu tick virus: a new coltivirus from Haemaphysalis flava ticks in Japan","volume":"242","author":"Fujita","year":"2017","journal-title":"Virus Res"},{"issue":"1","key":"2023111418455270500_CIT0027","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s40168-017-0352-9","article-title":"Laboratory colonization stabilizes the naturally dynamic microbiome composition of field collected Dermacentor andersoni ticks","volume":"5","author":"Gall","year":"2017","journal-title":"Microbiome"},{"issue":"9","key":"2023111418455270500_CIT0028","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1089\/vbz.2013.1568","article-title":"Infection with Colorado tick fever virus among humans and ticks in a national park and forest, Wyoming, 2010","volume":"14","author":"Geissler","year":"2014","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"5","key":"2023111418455270500_CIT0029","first-page":"1043","article-title":"Experimental infection of rhesus monkeys with Colorado tick fever virus","volume":"35","author":"Gerloff","year":"1959","journal-title":"Am J Pathol"},{"issue":"3","key":"2023111418455270500_CIT0030","doi-asserted-by":"crossref","first-page":"303","DOI":"10.7326\/0003-4819-88-3-303","article-title":"Colorado tick fever: clinical, epidemiologic, and laboratory aspects of 228 cases in Colorado in 1973\u20131974","volume":"88","author":"Goodpasture","year":"1978","journal-title":"Ann Intern Med"},{"issue":"7","key":"2023111418455270500_CIT0031","first-page":"273","article-title":"Occurrence of Colorado tick fever virus in Dermacentor andersoni ticks in British Columbia","volume":"59","author":"Hall","year":"1968","journal-title":"Can J Public Health"},{"issue":"1","key":"2023111418455270500_CIT0032","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jmedent\/43.1.17","article-title":"Distribution, seasonality, and hosts of the Rocky Mountain wood tick in the United States","volume":"43","author":"James","year":"2006","journal-title":"J Med Entomol"},{"issue":"1\u20132","key":"2023111418455270500_CIT0033","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.jviromet.2006.10.014","article-title":"Detection of Colorado tick fever viral RNA in acute human serum samples by a quantitative real-time RT-PCR assay","volume":"140","author":"Lambert","year":"2007","journal-title":"J Virol Methods"},{"issue":"4","key":"2023111418455270500_CIT0034","doi-asserted-by":"crossref","first-page":"837","DOI":"10.4269\/ajtmh.1982.31.837","article-title":"Survey for evidence of Colorado tick fever virus outside of the known endemic area in California","volume":"31","author":"Lane","year":"1982","journal-title":"Am J Trop Med Hyg"},{"key":"2023111418455270500_CIT0035","first-page":"103","article-title":"ICTV virus taxonomy profile: Spinareoviridae","volume":"2022","author":"Matthijnssens","year":"2022","journal-title":"J Gen Virol"},{"issue":"1","key":"2023111418455270500_CIT0036","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1093\/jmedent\/30.1.236","article-title":"Ecology of porcupines (Erethizon dorsatum) and Colorado tick fever virus in Rocky Mountain National Park, 1975\u20131977","volume":"30","author":"McLean","year":"1993","journal-title":"J Med Entomol"},{"issue":"1","key":"2023111418455270500_CIT0037","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4269\/ajtmh.1989.40.86","article-title":"The ecology of Colorado tick fever in Rocky Mountain National Park in 1974. III. Habitats supporting the virus","volume":"40","author":"McLean","year":"1989","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"2023111418455270500_CIT0038","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1099\/0022-1317-13-2-273","article-title":"Physicochemical and morphological relationships of some arthropod-borne viruses to bluetongue virus\u2014a new taxonomic group. Electron microscopic studies","volume":"13","author":"Murphy","year":"1971","journal-title":"J Gen Virol"},{"issue":"7","key":"2023111418455270500_CIT0039","doi-asserted-by":"crossref","first-page":"e0199644","DOI":"10.1371\/journal.pone.0199644","article-title":"Using citizen science to describe the prevalence and distribution of tick bite and exposure to tick-borne diseases in the United States","volume":"13","author":"Nieto","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"2023111418455270500_CIT0040","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1099\/0022-1317-39-1-73","article-title":"The development of Colorado tick fever virus within cells of the haemopoietic system","volume":"39","author":"Oshiro","year":"1978","journal-title":"J Gen Virol"},{"issue":"8","key":"2023111418455270500_CIT0041","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1089\/vbz.2022.0018","article-title":"Colorado tick fever virus in the far West: forgotten, but not gone","volume":"22","author":"Padgett","year":"2022","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"4","key":"2023111418455270500_CIT0042","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1128\/jvi.67.4.2389-2395.1993","article-title":"Replication of Colorado tick fever virus within human hematopoietic progenitor cells","volume":"67","author":"Philipp","year":"1993","journal-title":"J Virol"},{"issue":"4","key":"2023111418455270500_CIT0043","first-page":"339","article-title":"Eyach\u2014an arthropod-borne virus related to Colorado tick fever virus in the Federal Republic of Germany","volume":"20","author":"Rehse-K\u00fcpper","year":"1976","journal-title":"Acta Virol"},{"issue":"2","key":"2023111418455270500_CIT0044","first-page":"138","article-title":"Development of Colorado tick fever virus in the Rocky Mountain wood tick, Dermacentor andersoni","volume":"69","author":"Rozeboom","year":"1959","journal-title":"Am J Hyg"},{"key":"2023111418455270500_CIT0045","first-page":"447","article-title":"Biology of ticks","volume-title":"Biology of ticks","author":"Sonenshine","year":"1991"},{"issue":"6","key":"2023111418455270500_CIT0046","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1093\/jmedent\/12.6.651","article-title":"Contributions to the ecology of Colorado tick fever virus. 2. Population dynamics and host utilization of immature stages of the Rocky Mountain wood tick, Dermacentor andersoni","volume":"12","author":"Sonenshine","year":"1976","journal-title":"J Med Entomol"},{"issue":"3","key":"2023111418455270500_CIT0047","doi-asserted-by":"crossref","first-page":"561","DOI":"10.3201\/eid2903.221240","article-title":"Increase in Colorado tick fever virus disease cases and effect of COVID-19 pandemic on behaviors and testing practices, Montana, 2020","volume":"29","author":"Soto","year":"2023","journal-title":"Emerg Infect Dis"},{"issue":"2","key":"2023111418455270500_CIT0048","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1001\/archinte.1973.00320080124018","article-title":"Colorado tick fever. A review of 115 laboratory confirmed cases","volume":"131","author":"Spruance","year":"1973","journal-title":"Arch Intern Med"},{"issue":"1","key":"2023111418455270500_CIT0049","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s12985-017-0843-0","article-title":"A novel Coltivirus-related virus isolated from free-tailed bats from C\u00f4te d\u2019Ivoire is able to infect human cells in vitro","volume":"14","author":"Weiss","year":"2017","journal-title":"Virol J"},{"issue":"9","key":"2023111418455270500_CIT0050","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1089\/vbz.2018.2407","article-title":"Prevalence and strains of Colorado tick fever virus in Rocky Mountain wood ticks in the Bitterroot Valley, Montana","volume":"19","author":"Williamson","year":"2019","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"13","key":"2023111418455270500_CIT0051","doi-asserted-by":"crossref","first-page":"e00106","DOI":"10.1128\/JVI.00106-19","article-title":"Characterization of novel reoviruses Wad Medani Virus (Orbivirus) and Kundal virus (Coltivirus) collected from Hyalomma anatolicum ticks in India during surveillance for Crimean Congo hemorrhagic fever","volume":"93","author":"Yadav","year":"2019","journal-title":"J Virol"},{"issue":"5","key":"2023111418455270500_CIT0052","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/vbz.2014.1755","article-title":"Colorado tick fever in the United States, 2002\u20132012","volume":"15","author":"Yendell","year":"2015","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"7","key":"2023111418455270500_CIT0053","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.3390\/v13071396","article-title":"Viral RNA metagenomics of Hyalomma ticks collected from dromedary camels in Makkah Province, Saudi Arabia","volume":"13","author":"Zakham","year":"2021","journal-title":"Viruses"}],"container-title":["Journal of Medical Entomology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jme\/article-pdf\/60\/6\/1214\/53404758\/tjad094.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jme\/article-pdf\/60\/6\/1214\/53404758\/tjad094.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,14]],"date-time":"2023-11-14T13:54:42Z","timestamp":1699970082000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jme\/article\/60\/6\/1214\/7321678"}},"subtitle":[],"editor":[{"given":"Ary","family":"Faraji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":53,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,10,20]]},"published-print":{"date-parts":[[2023,11,14]]}},"URL":"https:\/\/doi.org\/10.1093\/jme\/tjad094","relation":{},"ISSN":["0022-2585","1938-2928"],"issn-type":[{"value":"0022-2585","type":"print"},{"value":"1938-2928","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,11,1]]},"published":{"date-parts":[[2023,10,20]]}}}