{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T14:46:28Z","timestamp":1751467588145,"version":"3.37.3"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Among approaches aimed at reducing Lyme disease risk in the environment, those targeting reservoirs of Borrelia burgdorferi Johnson are promising because they have the potential to reduce both the density of questing Ixodes scapularis Say (Acari: Ixodidea) ticks and the prevalence of B. burgdorferi in the tick population. In this 4-yr field study, we treated a population of wild small mammals with 2 densities of fluralaner baits and investigated the effect of the treatment on 3 parameters of the endemic cycle of B. burgdorferi: (i) the prevalence of infected Peromyscus mice (PIM), (ii) the density of questing nymphs (DON), and (iii) the prevalence of infected questing nymphs (NIP). We demonstrated that fluralaner baiting is effective at reducing tick infestation of Peromyscus mice, the main reservoir of B. burgdorferi in central and northeastern North America, in the laboratory and the field. Results from this study showed a significant decrease in B. burgdorferi infection in mice (odds ratio: 0.37 [CI95: 0.17 to 0.83]). A reduction in the DON between 45.4% [CI95: 22.4 to 61.6] and 62.7% [CI95: 45.9 to 74.2] occurred in treated area when compared with control areas. No significant effect was reported on the NIP. These results confirm the hypothesis that fluralaner baits have an effect on B. burgdorferi endemic cycle, with the potential to reduce the density of B. burgdorferi-infected ticks in the environment. Further studies performed in various habitats and public health intervention contexts are needed to refine and operationalize this approach for reducing Lyme disease risk in the environment.<\/jats:p>","DOI":"10.1093\/jme\/tjae091","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T17:57:47Z","timestamp":1723226267000},"page":"1203-1213","source":"Crossref","is-referenced-by-count":3,"title":["The effect of fluralaner treatment of small mammals on the endemic cycle of <i>Borrelia burgdorferi<\/i> in a natural environment"],"prefix":"10.1093","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9845-5446","authenticated-orcid":false,"given":"J\u00e9r\u00f4me","family":"Pelletier","sequence":"first","affiliation":[{"name":"D\u00e9partement de pathologie et microbiologie, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec, Canada"},{"name":"Groupe de recherche en \u00e9pid\u00e9miologie des zoonoses et sant\u00e9 publique, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec, Canada"},{"name":"Centre de recherche en sant\u00e9 publique de l\u2019Universit\u00e9 de Montr\u00e9al et du CIUSSS du Centre-Sud-de-l\u2019\u00cele-de-Montr\u00e9al, Universit\u00e9 de Montr\u00e9al , Montr\u00e9al, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-3603","authenticated-orcid":false,"given":"Catherine","family":"Bouchard","sequence":"additional","affiliation":[{"name":"Groupe de recherche en \u00e9pid\u00e9miologie des zoonoses et sant\u00e9 publique, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec, Canada"},{"name":"Public Health Risk Science Division, National Microbiology Laboratory, Public Health Agency of Canada , Saint-Hyacinthe, Qu\u00e9bec, 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Canada"},{"name":"Groupe de recherch\u00e9 sur les maladies infectieuses en production animale, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Gagnon","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et microbiologie, Facult\u00e9 de m\u00e9decine v\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec, Canada"},{"name":"Groupe de recherch\u00e9 sur les maladies infectieuses en production animale, Facult\u00e9 de M\u00e9decine V\u00e9t\u00e9rinaire, Universit\u00e9 de Montr\u00e9al , Saint-Hyacinthe, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Victoria Ibarra Meneses","sequence":"additional","affiliation":[{"name":"D\u00e9partement de pathologie et microbiologie, Facult\u00e9 de m\u00e9decine 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