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In this study, we aimed to determine the spatial efficacy of 2 plant-based repellent blends (Blend3 and Blend4 that had previously been found to successfully repel Aedes, Anopheles and Culex mosquitoes in wind tunnel assays) in excluding Aedes aegypti from the window entry. A new cage system was developed for parallel \u201cno-choice\u201d and \u201cchoice\u201d olfactometric assays. In the no-choice trial, Blends 3 and 4, as well as commercial products (N, N-diethyl-3-methylbenzamide, p-menthane-3,8-diol [PMD], 3-(N-n-butyl-N-acetyl)-amino-propionic acid ethyl ester, and 2-(2-hydroxyethyl)-1-methylpropylstyrene 1-piperidine carboxylate), were adsorbed into filter papers of different sizes and placed in a window created between 2 attached bug dorms. Then, the number of mosquitoes entering the window was counted through a 6-min period. In choice olfactometric assays, Blends 3, 4, and PMD were adsorbed into filter paper and the number of mosquitoes moving away from Blend 3 and PMD were compared. No-choice assays showed that Blend3 (P &amp;lt; 0.001) and Blend4 (P = 0.0012) were more repellent than the best commercial product PMD. Additionally, while Blend 4 was significantly more repellent than Blend 3 (P = 0.012) in the choice assay, overall, these 2 blends show promise as new repellents for the spatial exclusion of Aedes aegypti from window entry alone or as part of a \u201cpush-pull\u2019\u2019 strategy.<\/jats:p>","DOI":"10.1093\/jme\/tjae137","type":"journal-article","created":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T12:44:30Z","timestamp":1730465070000},"page":"39-46","source":"Crossref","is-referenced-by-count":3,"title":["<i>Novo<\/i> plant-based mosquito repellent shows promise for exclusion of <i>Aedes<\/i> mosquitoes from \u201cwindow\u201d entry"],"prefix":"10.1093","volume":"62","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9055-1556","authenticated-orcid":false,"given":"Sare I","family":"Yavasoglu","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Science, Ayd\u0131n Adnan Menderes University , 09010 Ayd\u0131n ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martyn J","family":"Wood","sequence":"additional","affiliation":[{"name":"Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas , 73100 Heraklion ,","place":["Greece"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C","family":"Bull","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Faculty of Science and Engineering, Swansea University , Singleton Park, Swansea SA2 8PP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-3407-1301","authenticated-orcid":false,"given":"Nergis","family":"Alk\u0131\u015f","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Science, Ayd\u0131n Adnan Menderes University , 09010 Ayd\u0131n ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1368-4061","authenticated-orcid":false,"given":"Emrecan","family":"Do\u011fan","sequence":"additional","affiliation":[{"name":"Department of Biology, Institute of Science, Ayd\u0131n Adnan Menderes University , 09010 Ayd\u0131n ,","place":["T\u00fcrkiye"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4376-2438","authenticated-orcid":false,"given":"Abeer M","family":"Alkhaibari","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Science, University of Tabuk , Tabul 71491 ,","place":["Kingdom of Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8789-9543","authenticated-orcid":false,"given":"Tariq M","family":"Butt","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Faculty of Science and Engineering, Swansea University , Singleton Park, Swansea SA2 8PP ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"issue":"4","key":"2025011604212850400_CIT0001","doi-asserted-by":"publisher","first-page":"715","DOI":"10.4269\/ajtmh.14-0471","article-title":"Environmental and genetic factors determine whether the mosquito Aedes aegypti lays eggs without a blood meal","volume":"92","author":"Ariani","year":"2015","journal-title":"Am. 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