{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:26:32Z","timestamp":1781720792178,"version":"3.54.5"},"reference-count":26,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica de Argentina","doi-asserted-by":"crossref","award":["PICT 2012\/1471"],"award-info":[{"award-number":["PICT 2012\/1471"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica de Argentina","doi-asserted-by":"crossref","award":["PICT 2017\/1512"],"award-info":[{"award-number":["PICT 2017\/1512"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chemotecnica S.A."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eugenol is a major component of the essential oils in cloves and other aromatic plants. In insects, it produces toxic effects and repellency, and there is evidence that its site of action is the octopamine receptor. The objective of the present study was to explore whether the octopamine receptor is involved in the hyperactivity produced by eugenol in the blood-sucking bug Triatoma infestans (Klug). This insect is the main vector of Chagas disease in Latin America. Four treatments were topically applied on third instar nymphs: 1) octopamine, 2) eugenol, 3) phentolamine hydrochloride (an antagonist of the octopamine receptor) followed by octopamine, and 4) phentolamine hydrochloride followed by eugenol. Both octopamine and eugenol hyperactivated the nymphs. However, pretreatment with phentolamine hydrochloride inhibited the hyperactivating effect of both compounds. These results are in agreement with previous works on Drosophila melanogaster (Meigen) (Diptera: Drosophilidae) and the American cockroach. They suggest that the octopamine receptor is a possible site of action for eugenol.<\/jats:p>","DOI":"10.1093\/jme\/tjz183","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T23:56:33Z","timestamp":1571702193000},"source":"Crossref","is-referenced-by-count":8,"title":["The Octopamine Receptor Is a Possible Target for Eugenol-Induced Hyperactivity in the Blood-Sucking Bug Triatoma infestans (Hemiptera: Reduviidae)"],"prefix":"10.1093","author":[{"given":"Mercedes M N","family":"Reynoso","sequence":"first","affiliation":[{"name":"Centro de Investigaciones de Plagas e Insecticidas, UNIDEF-CITEDEF-CONICET-CIPEIN, Juan B. de La Salle 4397, (B1603ALO) Villa Martelli, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Lucia","sequence":"additional","affiliation":[{"name":"Instituto de Ecolog\u00eda y Desarrollo Sustentable, Universidad Nacional de Luj\u00e1n (INEDES, CONICET-UNLu), Ruta 5 y Avenida Constituci\u00f3n, (B6700) Luj\u00e1n, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo N","family":"Zerba","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n e Ingenier\u00eda Ambiental, Universidad Nacional de San Mart\u00edn (UNSAM), (B1650HMQ) San Mart\u00edn, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal A","family":"Alzogaray","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones de Plagas e Insecticidas, UNIDEF-CITEDEF-CONICET-CIPEIN, Juan B. de La Salle 4397, (B1603ALO) Villa Martelli, Buenos Aires, Argentina"},{"name":"Instituto de Investigaci\u00f3n e Ingenier\u00eda Ambiental, Universidad Nacional de San Mart\u00edn (UNSAM), (B1650HMQ) San Mart\u00edn, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"2019102119390637300_CIT0001","author":"Baker","year":"2018"},{"key":"2019102119390637300_CIT0002","doi-asserted-by":"crossref","DOI":"10.1002\/9780470330319","volume-title":"Medical toxicology of natural substances","author":"Barceloux","year":"2008"},{"key":"2019102119390637300_CIT0003","doi-asserted-by":"crossref","first-page":"11122","DOI":"10.1523\/JNEUROSCI.2704-07.2007","article-title":"Flight initiation and maintenance deficits in flies with genetically altered biogenic amine levels","volume":"27","author":"Brembs","year":"2007","journal-title":"J. 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