{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T16:21:23Z","timestamp":1786810883883,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A study was performed to evaluate the implication of Protophormia terraenovae larvae as a surgical therapy for wounded skin. Three groups of sheep (n = 25) were considered based on larval doses. Groups 1 and 2 were artificially infested with low and high concentrations of L1 stage P. terraenovae, respectively, and group 0 served as a control. Skin biopsies were taken at 4 and 14 d postinfestation (D.P.If). A histopathological study was carried out to evaluate the lesions with a score, numbers of eosinophils and mast cells, and an immunohistochemical analysis of CD3, CD79\u03b1, and CD68 as T lymphocytes, B lymphosytes, and macrophages, respectively. The results indicated that higher larval doses led to faster regeneration by 14 D.P.If. Furthermore, the higher larval doses showed a high number of the CD68 marker and eosinophils and a low number of CD3 and CD79\u03b1 markers and mast cells. In addition, the number of mast cells, T lymphocytes, and macrophage markers increased when the lesion progressed; however, a low number of immunolabeled CD79\u03b1 cells and eosinophils were observed. The results indicate a possible positive effect of larvae in the healing of certain wounds.<\/jats:p>","DOI":"10.1093\/jme\/tjz185","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T14:17:25Z","timestamp":1575987445000},"page":"369-376","source":"Crossref","is-referenced-by-count":5,"title":["Histological and Immunohistochemical Study of Wounds in Sheep Skin in Maggot Therapy by Using Protophormia terraenovae (Diptera: Calliphoridae) Larvae"],"prefix":"10.1093","volume":"57","author":[{"given":"David","family":"Dur\u00e1n","sequence":"first","affiliation":[{"name":"Animal Medicine Department, Pathological Anatomy Unit, University of Extremadura. Avenida de la Universidad SN. C\u00e1ceres, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6377-7405","authenticated-orcid":false,"given":"Javier","family":"Galapero","sequence":"first","affiliation":[{"name":"Animal Medicine Department, Pathological Anatomy Unit, University of Extremadura. Avenida de la Universidad SN. C\u00e1ceres, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Frontera","sequence":"first","affiliation":[{"name":"Animal Health Department, Parasitology Unit, University of Extremadura. Avenida de la Universidad SN. C\u00e1ceres, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3481-7310","authenticated-orcid":false,"given":"Daniel","family":"Bravo-Barriga","sequence":"first","affiliation":[{"name":"Animal Health Department, Parasitology Unit, University of Extremadura. Avenida de la Universidad SN. C\u00e1ceres, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Blanco","sequence":"first","affiliation":[{"name":"Animal Health Department, Parasitology Unit, University of Extremadura. Avenida de la Universidad SN. C\u00e1ceres, Espa\u00f1a"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"G\u00f3mez","sequence":"first","affiliation":[{"name":"Animal Medicine Department, Pathological Anatomy Unit, University of Extremadura. Avenida de la Universidad SN. 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