{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:42:29Z","timestamp":1792197749084,"version":"4.4.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006088","name":"National Center for Emerging and Zoonotic Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006088","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The white-footed mouse, Peromyscus leucopus (Rafinesque), is a reservoir for the Lyme disease spirochete Borrelia burgdorferi sensu stricto in the eastern half of the United States, where the blacklegged tick, Ixodes scapularis Say (Acari: Ixodidae), is the primary vector. In the Midwest, an additional Lyme disease spirochete, Borrelia mayonii, was recorded from naturally infected I. scapularis and P. leucopus. However, an experimental demonstration of reservoir competence was lacking for a natural tick host. We therefore experimentally infected P. leucopus with B. mayonii via I. scapularis nymphal bites and then fed uninfected larvae on the mice to demonstrate spirochete acquisition and passage to resulting nymphs. Of 23 mice fed on by B. mayonii-infected nymphs, 21 (91%) developed active infections. The infection prevalence for nymphs fed as larvae on these infected mice 4 wk post-infection ranged from 56 to 98%, and the overall infection prevalence for 842 nymphs across all 21 P. leucopus was 75% (95% confidence interval, 72\u201377%). To assess duration of infectivity, 10 of the P. leucopus were reinfested with uninfected larval ticks 12 wk after the mice were infected. The overall infection prevalence for 480 nymphs across all 10 P. leucopus at the 12-wk time point was 26% (95% confidence interval, 23\u201331%), when compared with 76% (95% confidence interval, 71\u201379%) for 474 nymphs from the same subset of 10 mice at the 4-wk time point. We conclude that P. leucopus is susceptible to infection with B. mayonii via bite by I. scapularis nymphs and an efficient reservoir for this Lyme disease spirochete.<\/jats:p>","DOI":"10.1093\/jme\/tjz242","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T05:58:53Z","timestamp":1575957533000},"page":"927-932","source":"Crossref","is-referenced-by-count":18,"title":["Experimental Demonstration of Reservoir Competence of the White-Footed Mouse, Peromyscus leucopus (Rodentia: Cricetidae), for the Lyme Disease Spirochete, Borrelia mayonii (Spirochaetales: Spirochaetaceae)"],"prefix":"10.1093","volume":"57","author":[{"given":"Christina M","family":"Parise","sequence":"first","affiliation":[{"name":"Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole E","family":"Breuner","sequence":"first","affiliation":[{"name":"Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrias","family":"Hojgaard","sequence":"first","affiliation":[{"name":"Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn M","family":"Osikowicz","sequence":"first","affiliation":[{"name":"Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam J","family":"Replogle","sequence":"first","affiliation":[{"name":"Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J","family":"Eisen","sequence":"first","affiliation":[{"name":"Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Eisen","sequence":"first","affiliation":[{"name":"Division of Vector-Borne Diseases, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"2020050411482196400_CIT0001","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1093\/jme\/tjx248","article-title":"Lack of evidence for transovarial transmission of the Lyme disease spirochete Borrelia mayonii by infected female Ixodes scapularis (Acari: Ixodidae) ticks","volume":"55","author":"Breuner","year":"2018","journal-title":"J. Med. Entomol"},{"key":"2020050411482196400_CIT0002","volume-title":"Surveillance for Ixodes scapularis and pathogens found in this tick species in the United States","author":"CDC) Centers for Disease Control and Prevention","year":"2018"},{"key":"2020050411482196400_CIT0003","doi-asserted-by":"crossref","first-page":"6783","DOI":"10.1128\/AEM.70.11.6783-6788.2004","article-title":"Interaction and transmission of two Borrelia burgdorferi sensu stricto strains in a tick-rodent maintenance system","volume":"70","author":"Derdakova","year":"2004","journal-title":"Appl. Environ. 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An integrated guide for homeowners, pest control operators, and public health officials for the prevention of tick-associated disease","author":"Stafford","year":"2007"},{"key":"2020050411482196400_CIT0030","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.epidem.2016.12.002","article-title":"Co-feeding transmission facilitates strain coexistence in Borrelia burgdorferi, the Lyme disease agent","volume":"19","author":"States","year":"2017","journal-title":"Epidemics"},{"key":"2020050411482196400_CIT0031","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.ttbdis.2015.02.007","article-title":"Genetic variation in transmission success of the Lyme borreliosis pathogen Borrelia afzelii","volume":"6","author":"Tonetti","year":"2015","journal-title":"Ticks Tick Borne Dis"}],"container-title":["Journal of Medical Entomology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jme\/article-pdf\/57\/3\/927\/33161709\/tjz242.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jme\/article-pdf\/57\/3\/927\/33161709\/tjz242.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T15:49:37Z","timestamp":1588607377000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jme\/article\/57\/3\/927\/5670886"}},"subtitle":[],"editor":[{"given":"Sarah","family":"Hamer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,12,10]]},"references-count":31,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,12,10]]},"published-print":{"date-parts":[[2020,5,4]]}},"URL":"https:\/\/doi.org\/10.1093\/jme\/tjz242","relation":{},"ISSN":["0022-2585","1938-2928"],"issn-type":[{"value":"0022-2585","type":"print"},{"value":"1938-2928","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,5]]},"published":{"date-parts":[[2019,12,10]]}}}