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Although cryo-TEM has been widely applied to aqueous specimens, its application to organic solvent systems remains limited. Because the physicochemical properties of organic solvents differ markedly from those of water, efficient vitrification methods have not yet been well established to date. More critically, organic solvents are highly susceptible to electron-beam irradiation. In this study, we selected methanol\u2014the smallest polar alcohol molecule\u2014and optimized the vitrification protocol for the observation of samples containing organic solvents. This resulted in a reproducible blotting method for forming thin solvent films, along with suitable freezing conditions for producing amorphous methanol. We further aimed to expand the application of cryo-TEM to materials in organic solvent systems by performing cryogenic electron energy-loss spectroscopy (cryo-EELS) elemental mapping. The technique, recently developed by our group for frozen aqueous solutions, enabled the detection of elemental signals even from frozen methanol and provided insights into their spatial distributions. Furthermore, silicon signals from mesoporous silica nanoparticles (MSNs) dispersed in methanol were clearly observed. These results demonstrate that both solvent components and nanomaterials can be visualized and analyzed within frozen organic solvents, thereby expanding the potential of cryo-TEM for advanced materials research involving organic solvent systems.<\/jats:p>","DOI":"10.1093\/jmicro\/dfag027","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T11:21:04Z","timestamp":1779794464000},"source":"Crossref","is-referenced-by-count":0,"title":["Cryo-EELS elemental mapping of organic-solvent systems"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5347-7257","authenticated-orcid":false,"given":"Daisuke","family":"Unabara","sequence":"first","affiliation":[{"name":"Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University , 2-1-1 Katahira, Aoba-ku , Sendai, Miyagi 980-8577,","place":["Japan"]},{"name":"Tohoku Center of Excellence for Microscopy (TCEM), Tohoku University , 2-1-1 Katahira, Aoba-ku , Sendai, Miyagi 980-8577,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-8032","authenticated-orcid":false,"given":"Yohei K","family":"Sato","sequence":"additional","affiliation":[{"name":"Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University , 2-1-1 Katahira, Aoba-ku , Sendai, Miyagi 980-8577,","place":["Japan"]},{"name":"Tohoku Center of Excellence for Microscopy (TCEM), Tohoku University , 2-1-1 Katahira, Aoba-ku , Sendai, Miyagi 980-8577,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuku","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University , 2-1-1 Katahira, Aoba-ku , Sendai, Miyagi 980-8577,","place":["Japan"]},{"name":"Tohoku Center of Excellence for Microscopy (TCEM), Tohoku University , 2-1-1 Katahira, Aoba-ku , Sendai, Miyagi 980-8577,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yonekura","sequence":"additional","affiliation":[{"name":"Institute of Multidisciplinary Research for Advanced Materials (IMRAM), Tohoku University , 2-1-1 Katahira, Aoba-ku , Sendai, Miyagi 980-8577,","place":["Japan"]},{"name":"Tohoku Center of Excellence for Microscopy (TCEM), Tohoku University , 2-1-1 Katahira, Aoba-ku , Sendai, Miyagi 980-8577,","place":["Japan"]},{"name":"Biostructural Mechanism Laboratory, RIKEN SPring-8 Center , 1-1-1 Kouto , Sayo, Hyogo 679-5148,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,29]]},"reference":[{"key":"2026062513080005300_dfag027-B1","doi-asserted-by":"crossref","first-page":"102484","DOI":"10.1016\/j.sbi.2022.102484","article-title":"Recent advances and current trends in cryo-electron microscopy","volume":"77","author":"Guaita","year":"2022","journal-title":"Curr. 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