{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:34:20Z","timestamp":1792290860752,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[1979,7,1]],"date-time":"1979-07-01T00:00:00Z","timestamp":299635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1979,7]]},"DOI":"10.1093\/jn\/109.7.1321","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T05:56:37Z","timestamp":1515995797000},"page":"1321-1332","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Characteristics of Thyroid Function in Experimental Protein Malnutrition"],"prefix":"10.1016","volume":"109","author":[{"given":"Orien L.","family":"Tulp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia P.","family":"Krupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Elliot","family":"Danforth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward S.","family":"Horton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/109.7.1321_bib1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1093\/ajcn\/21.5.467","article-title":"Interrelationships of nutrition and endocrinology","volume":"21","author":"Eisenstein","year":"1968","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/109.7.1321_bib2","first-page":"666","article-title":"Effect of malnutrition on human growth hormone secretion","volume":"47","author":"Pimstone","year":"1973","journal-title":"S. Afr. Med. J"},{"key":"10.1093\/jn\/109.7.1321_bib3","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1210\/jcem-40-2-221","article-title":"Circulating thyroid hormones in adult patients with protein-calorie malnutrition","volume":"40","author":"Chopra","year":"1975","journal-title":"J. Clin. Endocr. Metab"},{"key":"10.1093\/jn\/109.7.1321_bib4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1753-4887.1974.tb06258.x","article-title":"Energy needs and energy utilization","volume":"32","author":"Hegsted","year":"1974","journal-title":"Nutr. Rev"},{"key":"10.1093\/jn\/109.7.1321_bib5","first-page":"370","article-title":"Endocrines in malnutrition","volume":"10","author":"Gopolan","year":"1956","journal-title":"Ind. J. Med. Sci"},{"key":"10.1093\/jn\/109.7.1321_bib6","first-page":"40","article-title":"Protein-calorie deficiency and disorders of the endocrine glands","volume":"2","author":"Heard","year":"1971","journal-title":"Hormones"},{"key":"10.1093\/jn\/109.7.1321_bib7","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/ajcn\/28.1.66","article-title":"Functional variations in the ultrastructure of the thyroid gland in malnourished infant monkeys","volume":"28","author":"Worthington","year":"1975","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/109.7.1321_bib8","first-page":"99","article-title":"The thyroid in malnutrition","volume":"36","author":"Stirling","year":"1961","journal-title":"Arch. Dis. Child"},{"key":"10.1093\/jn\/109.7.1321_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1677\/joe.0.0460093","article-title":"Thyroid function in protein-depleted rats","volume":"46","author":"Florsheim","year":"1970","journal-title":"J. Endocr"},{"key":"10.1093\/jn\/109.7.1321_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1210\/endo-77-1-87","article-title":"Some effects of protein deficiency on the rat thyroid","volume":"77","author":"Ramalingaswami","year":"1965","journal-title":"Endocrinology"},{"key":"10.1093\/jn\/109.7.1321_bib11","first-page":"354","article-title":"Thyroid function in protein malnutrition","volume":"62","author":"Talwalkar","year":"1974","journal-title":"Ind. J. Med. Res"},{"key":"10.1093\/jn\/109.7.1321_bib12","first-page":"1300","article-title":"Thyroid function in kwashiorkor","volume":"59","author":"Jaya Rao","year":"1971","journal-title":"Ind. J. Med. Res"},{"key":"10.1093\/jn\/109.7.1321_bib13","first-page":"321","article-title":"Effect of different percentages of protein intake on thyroid activity, protein-bound iodine, total thyroxine, and free thyroxine level of blood of rats","volume":"62","author":"Deb","year":"1973","journal-title":"Endocrinologie"},{"key":"10.1093\/jn\/109.7.1321_bib14","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/jcem-41-1-27","article-title":"High incidence of decreased serum triodothyronine concentrations in patients with non-thyroidal disease","volume":"41","author":"Bermudez","year":"1975","journal-title":"J. Clin. Endocr. Metab"},{"key":"10.1093\/jn\/109.7.1321_bib15","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1210\/endo-97-5-1321","article-title":"Development of the hypothalamic-pituitary axis in the neonatal rat","volume":"97","author":"Dussault","year":"1975","journal-title":"Endocrinology"},{"key":"10.1093\/jn\/109.7.1321_bib16","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/jn\/107.6.1068","article-title":"Effects of diet composition on serum levels of insulin, thyroxine, triiodothyronine, growth hormone, and corticosterone in rats","volume":"107","author":"Rabolli","year":"1977","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/109.7.1321_bib17","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1210\/endo-96-3-773","article-title":"Measurement of plasma and tissue triiodothyronine concentrations in the rat by radioimmunoassay","volume":"96","author":"Nejad","year":"1975","journal-title":"Endocrinology"},{"key":"10.1093\/jn\/109.7.1321_bib18","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1210\/jcem-34-6-938","article-title":"A radioimmunoassay for measurement of thyroxine in unextracted serum","volume":"34","author":"Chopra","year":"1972","journal-title":"J. Clin. Endocr. Metab"},{"key":"10.1093\/jn\/109.7.1321_bib19","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1210\/endo-87-5-1022","article-title":"Measurement of TSH in plasma and pituitary of the rat by a radioimmunoassay utilizing bovine TSH: Effect of thyroidectomy or thyroxine administration on plasma TSH levels","volume":"87","author":"Reichlin","year":"1970","journal-title":"Endocrinology"},{"key":"10.1093\/jn\/109.7.1321_bib20","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1152\/ajplegacy.1974.227.4.912","article-title":"Core temperature, O2 consumption, and early detection of ob\/ob genotype in mice","volume":"227","author":"Kaplan","year":"1975","journal-title":"Am. J. Physiol"},{"key":"10.1093\/jn\/109.7.1321_bib21","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1080\/01621459.1963.10500843","article-title":"Ordered hypothesis for multiple treatments: A significance test for linear ranks","volume":"58","author":"Page","year":"1963","journal-title":"J. Am. Stat. Assoc"},{"key":"10.1093\/jn\/109.7.1321_bib22","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jn\/83.4.293","article-title":"Effects of corn oil on metabolic efficiency of energy utilization by chicks","volume":"83","author":"Carew","year":"1964","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/109.7.1321_bib23","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1093\/jn\/106.8.1202","article-title":"Utilization of energy for maintenance and for fat and lean gains by mice selected for rapid postweaning growth rate","volume":"106","author":"Canoulty","year":"1976","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/109.7.1321_bib24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1677\/joe.0.0500445","article-title":"Effect of decreased dietary protein on the rate of thyroid hormone secretion and food consumption in rats","volume":"50","author":"Singh","year":"1971","journal-title":"J. Endocr"},{"key":"10.1093\/jn\/109.7.1321_bib25","first-page":"971","article-title":"Organ weights and water content of rats fed protein-deficient diets","volume":"38","author":"DeCastro","year":"1968","journal-title":"Bull.W. H. O,"},{"key":"10.1093\/jn\/109.7.1321_bib26","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1079\/BJN19630028","article-title":"Ambient temperature and survival on a protein-deficient diet","volume":"17","author":"Andik","year":"1963","journal-title":"Br. J. Nutr"},{"key":"10.1093\/jn\/109.7.1321_bib27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/ajcn\/28.3.246","article-title":"Physical growth of cebus monkeys, cebus albifrons, during protein or caloric deficiency","volume":"28","author":"Fleagle","year":"1975","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/109.7.1321_bib28","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/jn\/78.3.255","article-title":"Weight maintenance and food intake","volume":"78","author":"Miller","year":"1962","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/109.7.1321_bib29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1038\/220801a0","article-title":"Metabolic origins of thermogenesis induced by diet","volume":"220","author":"Stirling","year":"1968","journal-title":"Nature"},{"key":"10.1093\/jn\/109.7.1321_bib30","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/S0021-9258(18)69723-6","article-title":"Enhanced oxidation of \u03b1-glycerophosphate by mitochondria of thyroid-fed rats","volume":"234","author":"Lee","year":"1959","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/109.7.1321_bib31","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/S0021-9258(18)97593-9","article-title":"Influence of thyroid hormones on L-\u03b1-glycerophosphate dehydrogenases and other dehydrogenases in various organs of the rat","volume":"240","author":"Lee","year":"1965","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/109.7.1321_bib32","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1152\/ajplegacy.1975.228.5.1341","article-title":"Effects of thyroid hormone administration on skeletal muscle mitochondria","volume":"228","author":"Winder","year":"1975","journal-title":"Am. J. Physiol"},{"key":"10.1093\/jn\/109.7.1321_bib33","unstructured":"Danforth, E., Jr., Berger, A. G., Goldman, R. F. & Sims, E. A. H. (1978) Thermogenesis during weight gain. In: Recent advances in obesity research: II. Proceedings of the 2nd International Congress on obesity. ( Bray, G., ed.), C h. 23, pp. 229\u2013236, Neuman Publishing, London, UK."},{"key":"10.1093\/jn\/109.7.1321_bib34","unstructured":"Sims, E. A. H. (1975) Efficiency of gain in weight following overeating in normal subjects and in the obese. In: Obesity in Perspective ( Bray, G. A., ed.), Vo l. 2, Part 1, C h. 10, pp. 53\u201356. U. S. Government Printing Office, Washington, D.C."}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623277421?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623277421?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/109\/7\/1321\/24052943\/jn1090071321.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T04:06:40Z","timestamp":1686629200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623277421"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1979,7]]}},"alternative-id":["S0022316623277421"],"URL":"https:\/\/doi.org\/10.1093\/jn\/109.7.1321","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1979,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characteristics of Thyroid Function in Experimental Protein Malnutrition","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/109.7.1321","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1979 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}