{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:01:51Z","timestamp":1773093711370,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1980,1,1]],"date-time":"1980-01-01T00:00:00Z","timestamp":315532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1980,1]]},"DOI":"10.1093\/jn\/110.1.178","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T05:59:14Z","timestamp":1515995954000},"page":"178-188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["The Prevalence, Metabolism and Migration of Goblet Cells in Rat Intestine following the Induction of Rapid, Synchronous Vitamin A Deficiency"],"prefix":"10.1016","volume":"110","author":[{"given":"Wannee","family":"Rojanapo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian J.","family":"Lamb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James A.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/110.1.178_bib1","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0021-9258(18)94410-8","article-title":"Vitamin A and protein synthesis by rat intestinal mucosa.","volume":"244","author":"DeLuca","year":"1969","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/110.1.178_bib2","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1093\/jn\/107.4.552","article-title":"Effect of vitamin A deficiency on intestinal cell proliferation in the rat.","volume":"107","author":"Zile","year":"1977","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/110.1.178_bib3","unstructured":"Stewart, R. J. C. (1975) Bone pathology in experimental malnutrition. In: World Review of Nutrition and Dietetics ( Bourne, G. H., ed.), Vo l. 21, pp. 1\u201374, S. Karger, Basel."},{"key":"10.1093\/jn\/110.1.178_bib4","first-page":"1021","article-title":"The effect of vitamin A acid on tumori-genesis and protein production.","volume":"28","author":"Prutkin","year":"1968","journal-title":"Cancer Res"},{"key":"10.1093\/jn\/110.1.178_bib5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0304-4165(73)90091-3","article-title":"Glycoproteins from the hamster respiratory tract and their response to vitamin A.","volume":"297","author":"Bonnani","year":"1973","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/110.1.178_bib6","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/0014-4827(74)90654-5","article-title":"Altered glycoprotein synthesis in mouse epidermal cells treated with retinyl acetate in vitro.","volume":"86","author":"DeLuca","year":"1974","journal-title":"Exp. Cell. Res"},{"key":"10.1093\/jn\/110.1.178_bib7","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/0304-4165(64)90218-1","article-title":"Identification of free and conjugated retinoic acid as a product of retinal (vitamin A aldehyde) metabolism in the rat in vivo.","volume":"90","author":"Dunagin","year":"1964","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1093\/jn\/110.1.178_bib8","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/0006-291X(70)90057-4","article-title":"The biosynthesis of a mannolipid that contains a polar metabolite of 15-C14-retinol.","volume":"41","author":"DeLuca","year":"1970","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1093\/jn\/110.1.178_bib9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0006-291X(72)80156-6","article-title":"Galactosyltransfer in mouse mastocytoma: Synthesis of a galactose-containing polar metabolite of retinol.","volume":"46","author":"Helting","year":"1972","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1093\/jn\/110.1.178_bib10","doi-asserted-by":"crossref","first-page":"133138","DOI":"10.1016\/0014-5793(72)80694-X","article-title":"Formation of retinol glycosides with nucleotide sugars in the presence of whole homogenates of rat thyroid","volume":"28","author":"Rodriguez","year":"1972","journal-title":"FEBS Letters"},{"key":"10.1093\/jn\/110.1.178_bib11","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0016-5085(64)80053-6","article-title":"Absorption of Co5 labeled cyanocobalamin in protein deficiency. An experimental study in the Rhesus monkey.","volume":"46","author":"Deo","year":"1964","journal-title":"Gastroenterol"},{"key":"10.1093\/jn\/110.1.178_bib12","first-page":"61","article-title":"Dietary protein in relation to man's health.","volume":"20","author":"Brock","year":"1961","journal-title":"Fed. Proc. (Supplement)"},{"key":"10.1093\/jn\/110.1.178_bib13","unstructured":"F\u00e1bry, P. (1967) Metabolic consequences of the pattern of food intake. In: Section 6 (Alimentary Canal), Handbook of Physiology ( Code, C. F., ed.), Vo l. 1, pp. 31\u201349, American Physiological Society, Washington, DC."},{"key":"10.1093\/jn\/110.1.178_bib14","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/jn\/104.9.1140","article-title":"Induction of rapid, synchronous vitamin A deficiency in the rat.","volume":"104","author":"Lamb","year":"1974","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/110.1.178_bib15","doi-asserted-by":"crossref","unstructured":"Anzano, M. A., Lamb, A. J. & Olson, J. A. (1979) The somatic function of vitamin A: Growth, appetite, clinical sequences and survival following the induction of rapid, synchronous vitamin A deficiency in the rat. J. Nutr. (In press).","DOI":"10.1093\/jn\/109.8.1419"},{"key":"10.1093\/jn\/110.1.178_bib16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF00306031","article-title":"A method for the use of Zenker-formal fixation and the Periodic Acid Schiff staining technique in light microscopic radioautography.","volume":"32","author":"Kopriwa","year":"1972","journal-title":"Histochemie"},{"key":"10.1093\/jn\/110.1.178_bib17","doi-asserted-by":"crossref","unstructured":"Hendrix, T. R. & Bayless, T. M. (1970) Digestion: Intestinal secretion. In: Annual Review of Physiology ( Hall, V. E., Giese, A. C. & Sonnenschein, R. R., eds.), Vo l. 32, pp. 139\u2013164, Annual Reviews Inc., Palo Alto, CA.","DOI":"10.1146\/annurev.ph.32.030170.001035"},{"key":"10.1093\/jn\/110.1.178_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/aja.1001240303","article-title":"Origin and renewal of goblet cells in the epithelium of the mouse small intestine.","volume":"124","author":"Merzel","year":"1969","journal-title":"Am. J. Anat"},{"key":"10.1093\/jn\/110.1.178_bib19","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1083\/jcb.30.1.119","article-title":"Synthesis of the carbohydrate of mucus in the Golgi complex as shown by electron microscope radioautography of goblet cells from rats injected with glucose-3H.","volume":"30","author":"Neutra","year":"1966","journal-title":"J. Cell. Biol"},{"key":"10.1093\/jn\/110.1.178_bib20","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/ar.1091770405","article-title":"Maturation of goblet cells of the mouse small intestine as shown by the uptake of SS-sodium sulfate.","volume":"177","author":"Merzel","year":"1973","journal-title":"Anat. Res"},{"key":"10.1093\/jn\/110.1.178_bib21","unstructured":"Waterhouse, J. P. (1961) Histochemical and ultrastructural evidence of sites of activity in resting and pilocarpine-stimulated salivary glands of rat. J. Dent. Re s. 40, 1288 (abs.)."},{"key":"10.1093\/jn\/110.1.178_bib22","unstructured":"Koelle, G. B. (1970) Parasympathomimetic agents. In: The Pharmacological Basis of Therapeutics, 4th ed. ( Goodman, L. S. & Gilman, A., eds.), pp. 466\u2013477, The Macmillan Co., New York."},{"key":"10.1093\/jn\/110.1.178_bib23","unstructured":"Innes, I. R. & Nickerson, M. (1970) Drugs inhibiting the action of acetylcholine on structures innervated by postganglionic parasympathetic nerves (antimuscarinic or atropinic drugs). In: The Pharmacological Basis of Therapeutics, 4th ed. ( Goodman, L. S. & Gilman, A., eds.), pp. 524\u2013548, The Macmillan Co., New York."},{"key":"10.1093\/jn\/110.1.178_bib24","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/0014-4827(59)90063-1","article-title":"Cell population kinetics in the intestinal epithelium of the mouse.","volume":"17","author":"Quastler","year":"1959","journal-title":"Exp. Cell. Res"},{"key":"10.1093\/jn\/110.1.178_bib25","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1002\/j.1537-2197.1960.tb07171.x","article-title":"Duration of the nuclear cycle in Tradescantia paludosa root tips as measured with 3H-thymidine.","volume":"47","author":"Wimber","year":"1960","journal-title":"Am. J. Bot"},{"key":"10.1093\/jn\/110.1.178_bib26","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/0014-4827(65)90055-8","article-title":"Cell proliferation studies in the intestinal epithelium of the rat. I. Determination of the kinetic parameters.","volume":"39","author":"Cairnie","year":"1965","journal-title":"Exp. Cell. Res"},{"key":"10.1093\/jn\/110.1.178_bib27","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/0014-4827(72)90120-6","article-title":"Feedback control by functional villus cells on cell proliferation and maturation in intestinal epithelium.","volume":"73","author":"Galjaard","year":"1972","journal-title":"Exp. Cell. Res"},{"key":"10.1093\/jn\/110.1.178_bib28","first-page":"338","article-title":"Metabolism of retinoic acid in vitamin A deficient rats.","volume":"369","author":"Ito","year":"1974","journal-title":"Acta"},{"key":"10.1093\/jn\/110.1.178_bib29","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/aja.1001410404","article-title":"Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. II. Mucous cells.","volume":"141","author":"Cheng","year":"1974","journal-title":"Am. J. Anat."},{"key":"10.1093\/jn\/110.1.178_bib30","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/aja.1001410404","article-title":"Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. II. Mucous cells.","volume":"141","author":"Cheng","year":"1974","journal-title":"Am. J. Anat."},{"key":"10.1093\/jn\/110.1.178_bib31","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/jid.1961.146","article-title":"The effect of vita A on epithelial mitosis in vitro and in vivo.","volume":"37","author":"Sherman","year":"1961","journal-title":"J. Invest. Dermatol"},{"key":"10.1093\/jn\/110.1.178_bib32","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1152\/ajplegacy.1963.205.5.868","article-title":"Inhibition of intestinal epithelial cell renewal and migration induced by starvation.","volume":"205","author":"Brown","year":"1963","journal-title":"Am. J. Physiol"},{"key":"10.1093\/jn\/110.1.178_bib33","doi-asserted-by":"crossref","first-page":"695","DOI":"10.3181\/00379727-128-33103","article-title":"Cell population changes in the intestinal epithelium of the rat following starvation and protein depletion.","volume":"128","author":"Hopper","year":"1968","journal-title":"Proc. Soc. Exp. Biol. Med"},{"key":"10.1093\/jn\/110.1.178_bib34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1126\/science.177.4043.68","article-title":"Decreased RNA polymerase activity in mammalian zinc deficiency","volume":"177","author":"Sandstead","year":"1972","journal-title":"Science"},{"key":"10.1093\/jn\/110.1.178_bib35","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0006-291X(77)91621-7","article-title":"RNA polymerase II from wheat germ contains tightly bound zinc.","volume":"74","author":"Petranyi","year":"1977","journal-title":"Biochem. Biophys. Res. Commun"},{"key":"10.1093\/jn\/110.1.178_bib36","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1093\/jn\/81.4.383","article-title":"Action of vitamin A on liver homogenate oxidation of tricarboxylic acid cycle intermediates.","volume":"81","author":"DeLuca","year":"1963","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/110.1.178_bib37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1093\/jn\/70.1.53","article-title":"Zinc requirement and balance studies with the rat.","volume":"70","author":"Forbes","year":"1960","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/110.1.178_bib38","doi-asserted-by":"crossref","unstructured":"Greenfield, H. & Briggs, G. M. (1971) Nutritional methodology in metabolic research with rats. In: Annual review of Biochemistry ( Snell, E. E., Boyer, P. D., Meister, A. & Sinsheimer, R. L., eds.), Vo l. 40, p p. 549 572, Annual Review Inc., Palo Alto, CA.","DOI":"10.1146\/annurev.bi.40.070171.003001"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623278797?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623278797?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/110\/1\/178\/24052904\/jn1100010178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T04:10:02Z","timestamp":1686629402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623278797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,1]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1980,1]]}},"alternative-id":["S0022316623278797"],"URL":"https:\/\/doi.org\/10.1093\/jn\/110.1.178","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1980,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Prevalence, Metabolism and Migration of Goblet Cells in Rat Intestine following the Induction of Rapid, Synchronous Vitamin A Deficiency","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/110.1.178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1980 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}