{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T13:11:34Z","timestamp":1770469894244,"version":"3.49.0"},"reference-count":13,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[1981,6,1]],"date-time":"1981-06-01T00:00:00Z","timestamp":360201600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1981,6]]},"DOI":"10.1093\/jn\/111.6.979","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T05:50:03Z","timestamp":1515995403000},"page":"979-983","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Hepatic Cytochrome P-450 and Microsomal Heme Oxygenase in Copper-Deficient Rats"],"prefix":"10.1016","volume":"111","author":[{"given":"Darryl M.","family":"Williams","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond F.","family":"Burk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen G.","family":"Jenkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard A.","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/111.6.979_bib1","unstructured":"Lee, G. R., Williams, D. M. & Cartwright, G. E. (1976) Role of copper in iron metabolism and heme biosynthesis. In: Trace Elements in Human Health and Disease, vol. 1: Zinc and Copper ( Prasad, A. ed.), pp. 373\u2013390, Academic Press, New York."},{"key":"10.1093\/jn\/111.6.979_bib2","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1172\/JCI106460","article-title":"The role of ceruloplasmin in iron metabolism","volume":"49","author":"Roeser","year":"1970","journal-title":"J. Clin. Invest"},{"key":"10.1093\/jn\/111.6.979_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1182\/blood.V48.1.77.77","article-title":"Role of copper in mitochondrial iron metabolism","volume":"48","author":"Williams","year":"1976","journal-title":"Blood"},{"key":"10.1093\/jn\/111.6.979_bib4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1749-6632.1975.tb41553.x","article-title":"Enzymatic formation of bilirubin","volume":"244","author":"Schmid","year":"1975","journal-title":"Ann. NY Acad. Sci"},{"key":"10.1093\/jn\/111.6.979_bib5","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1152\/ajplegacy.1974.227.5.1094","article-title":"Ferroxidase activity of rat ceruloplasmin","volume":"227","author":"Williams","year":"1974","journal-title":"Am. J. Physiol"},{"key":"10.1093\/jn\/111.6.979_bib6","first-page":"161","article-title":"An improved colorimetric enzymatic assay of ceruloplasmin","volume":"58","author":"Ravin","year":"1961","journal-title":"J. Lab. Clin. Med"},{"key":"10.1093\/jn\/111.6.979_bib7","doi-asserted-by":"crossref","unstructured":"Wharton, D. C. & Tzagoloff A (1967) Cytochrome oxidase from beef heart mitochondria. In: Methods in Enzymology, vol. 10 ( Estabrook, R. W. & Pullman, M. E., eds.), pp. 245\u2013250, Academic Press, New York.","DOI":"10.1016\/0076-6879(67)10048-7"},{"key":"10.1093\/jn\/111.6.979_bib8","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/111.6.979_bib9","first-page":"242","article-title":"Phenobarbital (PB)-mediated accelerated degradation of hepatic heme (HH) in selenium (Se) deficiency","volume":"18","author":"Correia","year":"1976","journal-title":"Pharmacologist"},{"key":"10.1093\/jn\/111.6.979_bib10","first-page":"261","article-title":"Determina- tion of the cytochrome P-450 content of small samples of liver","volume":"12","author":"Raj","year":"1970","journal-title":"Pharmacologist"},{"key":"10.1093\/jn\/111.6.979_bib11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1042\/bj1680105","article-title":"Accelerated hepatic haem catabolism in the selenium-deficient rat","volume":"168","author":"Burk","year":"1977","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/111.6.979_bib12","first-page":"555","article-title":"Effects of copper deficiency on superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in rat lung and liver","volume":"39","author":"Jenkinson","year":"1980","journal-title":"Fed. Proc"},{"key":"10.1093\/jn\/111.6.979_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1042\/bj1800257","article-title":"Induction of liver cell haem oxygenase in iron-overloaded rats","volume":"180","author":"Ibrahim","year":"1976","journal-title":"Biochem. J"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623238328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623238328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/111\/6\/979\/24054673\/jn1110060979.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,13]],"date-time":"2023-06-13T03:24:46Z","timestamp":1686626686000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623238328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,6]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1981,6]]}},"alternative-id":["S0022316623238328"],"URL":"https:\/\/doi.org\/10.1093\/jn\/111.6.979","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1981,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic Cytochrome P-450 and Microsomal Heme Oxygenase in Copper-Deficient Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/111.6.979","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1981 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}