{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:48:53Z","timestamp":1760204933583},"reference-count":28,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[1982,8,1]],"date-time":"1982-08-01T00:00:00Z","timestamp":397008000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1982,8]]},"DOI":"10.1093\/jn\/112.8.1481","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T10:14:03Z","timestamp":1515406443000},"page":"1481-1489","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["A New Vaginal Smear Assay for Vitamin A in Rats"],"prefix":"10.1016","volume":"112","author":[{"given":"William K.","family":"Sietsema","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector F.","family":"DeLuca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/112.8.1481_bib1","first-page":"335","article-title":"On the relations between fertility and nutrition II. The ovulation rhythm in the rat on inadequate nutritional regimes.","volume":"1","author":"Evans","year":"1922","journal-title":"J. Metab. Res."},{"key":"10.1093\/jn\/112.8.1481_bib2","first-page":"26","article-title":"The influence of vitamin A deficiency on the oestrous cycle of the rat.","volume":"67","author":"Coward","year":"1929","journal-title":"J. Phy-siol."},{"key":"10.1093\/jn\/112.8.1481_bib3","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1113\/jphysiol.1930.sp002653","article-title":"The influence of vitamin A deflciency on the oestrous cycle of the rat.","volume":"69","author":"Coward","year":"1930","journal-title":"J. Physiol."},{"key":"10.1093\/jn\/112.8.1481_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1242\/jeb.3.4.251","article-title":"The effects of fat-soluble vitamin A deflciency on reproduction in the rat.","volume":"3","author":"Parkes","year":"1926","journal-title":"Brit. J. Exp. Biol."},{"key":"10.1093\/jn\/112.8.1481_bib5","first-page":"756","article-title":"Avitaminosis III. Pathologie changes in tissues of the albino rat during early stages of vitamin A deflciency.","volume":"13","author":"Thatcher","year":"1932","journal-title":"Arch. Pathol."},{"key":"10.1093\/jn\/112.8.1481_bib6","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0021-9258(20)74018-4","article-title":"The effect of inadequate vitamin A on the sexual physiology of the female.","volume":"77","author":"Evans","year":"1928","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/112.8.1481_bib7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0021-9258(18)84301-0","article-title":"Human milk studies I. Technique employai in vitamin studies.","volume":"73","author":"Macy","year":"1927","journal-title":"J. Biol. Chem."},{"key":"10.1093\/jn\/112.8.1481_bib8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1126\/science.76.1975.417","article-title":"The vaginal smear method of determining vitamin A.","volume":"76","author":"Baumann","year":"1932","journal-title":"Science"},{"key":"10.1093\/jn\/112.8.1481_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jn\/6.1.1","article-title":"Continual cornified vaginal cells as an index of avitaminosis-A in rats.","volume":"6","author":"Aberle","year":"1933","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.8.1481_bib10","first-page":"80","article-title":"Vaginal cor-nification as a criterion of vitamin A-deficiency in the rat.","volume":"58","author":"Mason","year":"1934","journal-title":"Anat. Rec."},{"key":"10.1093\/jn\/112.8.1481_bib11","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1093\/jn\/9.6.725","article-title":"Relation of castration to vitamin A deflciency in the rat.","volume":"9","author":"Mason","year":"1935","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.8.1481_bib12","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/jn\/9.6.735","article-title":"Changes in the vaginal epithelium of the rat after vitamin A deflciency.","volume":"9","author":"Mason","year":"1935","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.8.1481_bib13","first-page":"17","article-title":"On an invariable and characteristic disturbance of reproductive function in animals reared on a diet deficient in fat-soluble vitamin A.","volume":"23","author":"Evans","year":"1922","journal-title":"Anat. Rec."},{"key":"10.1093\/jn\/112.8.1481_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/jn\/10.1.1","article-title":"The demonstration of oestrus in the vitamin A-deficient rat by supravital study of the vaginal smears.","volume":"10","author":"Mason","year":"1935","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.8.1481_bib15","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1042\/bj0292736","article-title":"The determination of vitamin A by means of its influence on the vaginal contents of the rat.","volume":"29","author":"Coward","year":"1935","journal-title":"Biochem. J."},{"key":"10.1093\/jn\/112.8.1481_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/jn\/18.2.169","article-title":"The minimum vitamin A and carotene requirement of the rat.","volume":"18","author":"Goss","year":"1939","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.8.1481_bib17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jn\/28.5.365","article-title":"The biological assay of vitamin A by means of its influence on the cellular contents of the vagina of rats.","volume":"28","author":"Pugsley","year":"1944","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.8.1481_bib18","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/9780470110201.ch2","article-title":"Determination of vitamin A.","volume":"4","author":"Embree","year":"1957","journal-title":"Methods Biochem. Anal."},{"key":"10.1093\/jn\/112.8.1481_bib19","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1079\/BJN19570034","article-title":"Some observations on the biological assay of vitamin A and its precursore by the vaginal smear method.","volume":"2","author":"Clarke","year":"1957","journal-title":"Brit. J. Nutr."},{"key":"10.1093\/jn\/112.8.1481_bib20","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0083-6729(08)60868-7","article-title":"Bioassay of vitamin A compounds.","volume":"18","author":"Harris","year":"1960","journal-title":"Vitam. Horm."},{"key":"10.1093\/jn\/112.8.1481_bib21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/aja.1000950207","article-title":"Effect of locally applied vitamin A and estrogen on the rat vagina.","volume":"95","author":"Kahn","year":"1954","journal-title":"Am. J. Anat."},{"key":"10.1093\/jn\/112.8.1481_bib22","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/jn\/110.11.2225","article-title":"The biological activity of 5,6-epoxyretinoic acid.","volume":"110","author":"Zile","year":"1980","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.8.1481_bib23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/250064a0","article-title":"\u03b1-and \u03b2-Retinyl acetate reverse metaplasias of vitamin A deficiency in hamster trachea in organ culture.","volume":"250","author":"Clamon","year":"1974","journal-title":"Nature"},{"key":"10.1093\/jn\/112.8.1481_bib24","first-page":"3413","article-title":"Structure-activity relationships of retinoids in hamster tracheal organ culture.","volume":"40","author":"Newton","year":"1980","journal-title":"Cancer Res."},{"key":"10.1093\/jn\/112.8.1481_bib25","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.1073\/pnas.77.6.3230","article-title":"Characterization of retinoyl-\u03b2-glucuronide as a minor metabolite of retinoic acid in bile.","volume":"77","author":"Zile","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1093\/jn\/112.8.1481_bib26","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/0006-291X(79)91147-1","article-title":"In vitro epoxidation of all-transretinoic acid in rat tissue homogenates.","volume":"90","author":"Sietsema","year":"1979","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1093\/jn\/112.8.1481_bib27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1113\/expphysiol.1938.sp000774","article-title":"Mechanism of oestrus inhibition in the mouse during pregnancy.","volume":"28","author":"Robson","year":"1938","journal-title":"Quart. J. Exp. Physiol."},{"key":"10.1093\/jn\/112.8.1481_bib28","first-page":"397","article-title":"\u03b2-Glucuron-idase.","volume":"4","author":"Levvy","year":"1960","journal-title":"The Enzymes"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623198786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623198786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/112\/8\/1481\/23997157\/jn1120081481.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T13:14:45Z","timestamp":1693401285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623198786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,8]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1982,8]]}},"alternative-id":["S0022316623198786"],"URL":"https:\/\/doi.org\/10.1093\/jn\/112.8.1481","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1982,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A New Vaginal Smear Assay for Vitamin A in Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/112.8.1481","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1982 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}