{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T04:12:48Z","timestamp":1780546368206,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[1982,9,1]],"date-time":"1982-09-01T00:00:00Z","timestamp":399686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1982,9]]},"DOI":"10.1093\/jn\/112.9.1706","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T08:32:59Z","timestamp":1515400379000},"page":"1706-1717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":106,"title":["Effect of Dietary or Genetic Copper Deficiency on Brain Catecholamines, Trace Metals and Enzymes in Mice and Rats"],"prefix":"10.1016","volume":"112","author":[{"given":"Joseph R.","family":"Prohaska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/112.9.1706_bib1","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/ajcn\/28.6.638","article-title":"Control of brain monoamine synthesis by diet and plasma amino acids.","volume":"28","author":"Wurtman","year":"1975","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1093\/jn\/112.9.1706_bib2","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0031-6997(25)06920-0","article-title":"Influence of specific nutrients on catecholamine synthesis and metabolism.","volume":"24","author":"Sourkes","year":"1972","journal-title":"Pharmacol. Rev."},{"key":"10.1093\/jn\/112.9.1706_bib3","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1126\/science.185.4146.183","article-title":"Brain catechol synthesis: control by brain tyrosine concentration.","volume":"185","author":"Wurtman","year":"1974","journal-title":"Science"},{"key":"10.1093\/jn\/112.9.1706_bib4","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1471-4159.1974.tb06920.x","article-title":"Copper deficiency in the developing rat brain: a possible model for Menkes' steely-hair disease.","volume":"23","author":"Prohaska","year":"1974","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/112.9.1706_bib5","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1471-4159.1975.tb06956.x","article-title":"Copper deficiency in the developing rat brain: evidence for abnormal mitochondria.","volume":"25","author":"Prohaska","year":"1975","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/112.9.1706_bib6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1471-4159.1977.tb07728.x","article-title":"Effect of copper deficiency on the concentrations of catecholamines and related enzyme activities in the rat brain.","volume":"28","author":"Morgan","year":"1977","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/112.9.1706_bib7","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1111\/j.1471-4159.1980.tb09968.x","article-title":"Dopamine and norepinephrine in discrete areas of the copper-deficient rat brain.","volume":"34","author":"Feller","year":"1980","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/112.9.1706_bib8","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1471-4159.1976.tb01495.x","article-title":"Effect of copper status on brain neurotransmitter metabolism in the lamb.","volume":"26","author":"O'Dell","year":"1976","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/112.9.1706_bib9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF00485963","article-title":"Aromatic amino acid metabolism in brindled (Mobr) and viable-brindled (Movbr), two alleles at the mottled locus in the mouse.","volume":"6","author":"Hunt","year":"1972","journal-title":"Biochem. Genet."},{"key":"10.1093\/jn\/112.9.1706_bib10","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1111\/j.1471-4159.1972.tb03818.x","article-title":"An inherited deficiency in noradrenaline biosynthesis in the brindled mouse.","volume":"19","author":"Hunt","year":"1972","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/112.9.1706_bib11","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/249852a0","article-title":"Primary defect in copper transport underlies mottled mutants in the mouse.","volume":"249","author":"Hunt","year":"1974","journal-title":"Nature"},{"key":"10.1093\/jn\/112.9.1706_bib12","first-page":"79","article-title":"Catecholamine biosynthesis and the activity of a number of copper-dependent enzymes in the copper deficient mottled mouse mutants.","volume":"57C","author":"Hunt","year":"1977","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1093\/jn\/112.9.1706_bib13","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF00691800","article-title":"Neuronal degeneration in the brain of the brindled mouse.","volume":"45","author":"Yajima","year":"1979","journal-title":"Acta Neuropathol."},{"key":"10.1093\/jn\/112.9.1706_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0271-5317(81)80098-X","article-title":"Comparison between dietary and genetic copper deficiency in mice: copperdependent anemia.","volume":"1","author":"Prohaska","year":"1981","journal-title":"Nutr. Res."},{"key":"10.1093\/jn\/112.9.1706_bib15","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1471-4159.1978.tb06573.x","article-title":"Determination of catecholamines in rat brain parts by reverse-phase ion-pair liquid chromatography.","volume":"31","author":"Felice","year":"1978","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/112.9.1706_bib16","series-title":"Trace Element Metabolism in Man and Animals (TEMA-4)","first-page":"275","article-title":"Changes in brain enzymes accompanying deficiencies of the trace elements, copper, selenium, or zinc.","author":"Prohaska","year":"1981"},{"key":"10.1093\/jn\/112.9.1706_bib17","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0006-2944(74)90035-0","article-title":"A simple and sensitive assay for dopamine-0-hydroxylase activity by dual-wavelength spectrophotometry.","volume":"10","author":"Kato","year":"1974","journal-title":"Biochem. Med."},{"key":"10.1093\/jn\/112.9.1706_bib18","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/0003-2697(73)90189-9","article-title":"Improved rapidity and precision in the determination of brain 2',3'-cyclic nucleotide 3'-phosphohy- drolase.","volume":"56","author":"Prohaska","year":"1973","journal-title":"Anal. Biochem."},{"key":"10.1093\/jn\/112.9.1706_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0009-2797(77)90012-6","article-title":"Interactions between cadmium, selenium and glutathione peroxidase in rat testis.","volume":"18","author":"Prohaska","year":"1977","journal-title":"Chem. Biol. Interact."},{"key":"10.1093\/jn\/112.9.1706_bib20","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/jn\/107.7.1340","article-title":"Report of the American Institute of Nutrition Ad Hoc Committee on Standards for Nutritional Studies.","volume":"107","year":"1977","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.9.1706_bib21","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/jn\/112.1.197","article-title":"Effects of copper deficiency on the activity of the selenoenzyme glutathione peroxidase and on excretion and tissue retention of 75SeO32-.","volume":"112","author":"Jenkinson","year":"1982","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.9.1706_bib22","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1126\/science.7244654","article-title":"Copper deficiency suppresses the immune response of mice.","volume":"213","author":"Prohaska","year":"1981","journal-title":"Science"},{"key":"10.1093\/jn\/112.9.1706_bib23","series-title":"Biological Roles of Copper","first-page":"247","article-title":"Copper and neurological function.","author":"Hunt","year":"1980"},{"key":"10.1093\/jn\/112.9.1706_bib24","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/0306-3623(81)90068-9","article-title":"The effect of nutritional copper deprivation on the catecholamine content and dopamine-\u03b2-hydroxylase activity of rat and cattle adrenal glands.","volume":"12","author":"Hesketh","year":"1981","journal-title":"Gen. Pharmacol."},{"key":"10.1093\/jn\/112.9.1706_bib25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/0014-2999(67)90058-1","article-title":"Conversion of HC-dopamine to cardiac I4C-noradrenaline in the copper-deficient rat.","volume":"1","author":"Missala","year":"1967","journal-title":"Eur. J. Pharmacol."},{"key":"10.1093\/jn\/112.9.1706_bib26","first-page":"447","article-title":"Maladie de Menkes.","volume":"32","author":"Rohmer","year":"1977","journal-title":"Etude de deux enzymes cupro-depen- dantes. P\u00e9diatrie"},{"key":"10.1093\/jn\/112.9.1706_bib27","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0022-3565(25)30199-0","article-title":"Effects of reserpine on activities and amounts of tyrosine hydroxylase and dopamine-\u03b2-hydroxylase in catecholamine neuronal systems in rat brain.","volume":"193","author":"Reis","year":"1975","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1093\/jn\/112.9.1706_bib28","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1093\/jn\/110.10.2085","article-title":"Effects of chronic ascorbic acid deficiency on guinea pig lysosomal hydrolase activities.","volume":"110","author":"Hoehn","year":"1980","journal-title":"J. Nutr."},{"key":"10.1093\/jn\/112.9.1706_bib29","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0028-3908(80)90148-3","article-title":"The effects of iron deficiency on brain biogenic monoamine biochemistry and function in rats.","volume":"19","author":"Youdim","year":"1980","journal-title":"Neuropharmacol."},{"key":"10.1093\/jn\/112.9.1706_bib30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0361-9230(77)90064-8","article-title":"Perinatal malnutrition: Effects on brain norepinephrine content.","volume":"2","author":"Bums","year":"1977","journal-title":"Brain Res. Bull."},{"key":"10.1093\/jn\/112.9.1706_bib31","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1126\/science.7058348","article-title":"Perinatal undemutrition reduces alpha and beta adrenergic receptor binding in adult rat brain.","volume":"215","author":"Keller","year":"1982","journal-title":"Science"},{"key":"10.1093\/jn\/112.9.1706_bib32","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1471-4159.1982.tb08658.x","article-title":"Alterations in neurotransmitter receptor binding in discrete areas of the copper-deficient rat brain.","volume":"38","author":"Feller","year":"1982","journal-title":"J. Neurochem."},{"key":"10.1093\/jn\/112.9.1706_bib33","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1073\/pnas.74.10.4501","article-title":"Norepinephrine induces glial-specific enzyme activity in cultured glioma cells.","volume":"74","author":"McMorris","year":"1977","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623199068?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623199068?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/112\/9\/1706\/23195040\/jn1120091706.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T13:22:24Z","timestamp":1751203344000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623199068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9]]},"references-count":33,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1982,9]]}},"alternative-id":["S0022316623199068"],"URL":"https:\/\/doi.org\/10.1093\/jn\/112.9.1706","relation":{},"ISSN":["0022-3166"],"issn-type":[{"value":"0022-3166","type":"print"}],"subject":[],"published":{"date-parts":[[1982,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of Dietary or Genetic Copper Deficiency on Brain Catecholamines, Trace Metals and Enzymes in Mice and Rats","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/112.9.1706","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1982 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}