{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:40:15Z","timestamp":1760985615786,"version":"3.41.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[1986,11,1]],"date-time":"1986-11-01T00:00:00Z","timestamp":531187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[1986,11,1]],"date-time":"1986-11-01T00:00:00Z","timestamp":531187200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Nutrition"],"published-print":{"date-parts":[[1986,11]]},"DOI":"10.1093\/jn\/116.11.2278","type":"journal-article","created":{"date-parts":[[2018,1,8]],"date-time":"2018-01-08T11:24:57Z","timestamp":1515410697000},"page":"2278-2289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Ascorbic Acid Requirement for the Induction of Microsomal Drug-Metabolizing Enzymes in a Rat Mutant Unable to Synthesize Ascorbic Acid"],"prefix":"10.1016","volume":"116","author":[{"given":"Fumihiko","family":"Horio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuto","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiyo","family":"Kohmura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susumu","family":"Makino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1093\/jn\/116.11.2278_bib1","first-page":"374","article-title":"Osteogenic disorder rat","volume":"29","author":"Makino","year":"1980","journal-title":"Exp. Anim. Tokyo"},{"key":"10.1093\/jn\/116.11.2278_bib2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/BF01952551","article-title":"A rat mutant unable to synthesize vitamin C","volume":"40","author":"Mizushima","year":"1984","journal-title":"Experientia"},{"key":"10.1093\/jn\/116.11.2278_bib3","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1093\/jn\/115.12.1630","article-title":"Ascorbic acid requirement in a rat mutant unable to synthesize ascorbic acid","volume":"115","author":"Horio","year":"1985","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/116.11.2278_bib4","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1749-6632.1961.tb46111.x","article-title":"Metabolic interactions between l-ascorbic acid and drugs","volume":"92","author":"Conney","year":"1961","journal-title":"Ann. NY Acad. Sci"},{"key":"10.1093\/jn\/116.11.2278_bib5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/jn\/112.3.416","article-title":"Effects of some xenobiotics on ascorbic acid metabolism in rats","volume":"112","author":"Horio","year":"1982","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/116.11.2278_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3177\/jnsv.29.233","article-title":"Effect of several xenobiotics on the activities of enzymes affecting ascorbic acid synthesis in rats","volume":"29","author":"Horio","year":"1983","journal-title":"J. Nutr. Sci. Vitaminol"},{"key":"10.1093\/jn\/116.11.2278_bib7","first-page":"3101","article-title":"Effect of some xenobiotics on the activities of enzymes relating to the glucuronic acid pathway and on the ascorbic acid metabolism in guinea pigs","volume":"46","author":"Horio","year":"1982","journal-title":"Agric. Biol. Chem"},{"key":"10.1093\/jn\/116.11.2278_bib8","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/jn\/68.3.405","article-title":"Amino acid balance and imbalance. I. Dietary level of protein and amino acid imbalance","volume":"68","author":"Harper","year":"1959","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/116.11.2278_bib9","series-title":"Environmental Health Criteria 2","first-page":"18","article-title":"Polychlorinated biphenyls and terphenyls","year":"1976"},{"key":"10.1093\/jn\/116.11.2278_bib10","unstructured":"Ohara,T. (1973) Shokuhinbunseki Handbook (in Japanese), pp. 301-305, Kenpaku Co., Tokyo."},{"key":"10.1093\/jn\/116.11.2278_bib11","unstructured":"Mazel,P. (1974) In: Fundamentals of Drug Metabolism and Drug Disposition (La Du, B. N., Mandel, H. G. & Way, E. L., eds.), pp. 514-552, Hirokawa Publishing Co., Tokyo."},{"key":"10.1093\/jn\/116.11.2278_bib12","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1042\/bj0550416","article-title":"The colorimetric estimation of formaldehyde by means of Hantzch reaction","volume":"55","author":"Nash","year":"1953","journal-title":"Biochem. J"},{"key":"10.1093\/jn\/116.11.2278_bib13","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monooxide binding pigment of liver microsomes","volume":"239","author":"Omura","year":"1964","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/116.11.2278_bib14","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0021-9258(18)93967-0","article-title":"Microsomal triphosphopyridine nucleotidecytochrome c reductase of liver","volume":"237","author":"Williams","year":"1962","journal-title":"J. Biol. Chem"},{"key":"10.1093\/jn\/116.11.2278_bib15","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1093\/jn\/112.9.1796","article-title":"NADPH-dependent reduction of cytochrome P-450 in liver microsomes from vitamin C-deficient guinea pigs: effect of benzphetamine","volume":"112","author":"Rikans","year":"1982","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/116.11.2278_bib16","doi-asserted-by":"crossref","first-page":"164","DOI":"10.2307\/2527799","article-title":"Multiple-range tests for correlated and heteroscedastic means","volume":"13","author":"Duncan","year":"1957","journal-title":"Biometrics"},{"key":"10.1093\/jn\/116.11.2278_bib17","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/0006-2952(72)90362-0","article-title":"Ascorbic acid and drug metabolism","volume":"21","author":"Zannoni","year":"1972","journal-title":"Biochem. Pharmacol"},{"key":"10.1093\/jn\/116.11.2278_bib18","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0041-008X(73)90222-6","article-title":"The effect of protein quality and ascorbic acid deficiency on stimulation of hepatic microsomal enzymes in guinea pigs","volume":"24","author":"Chadwick","year":"1973","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1093\/jn\/116.11.2278_bib19","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1016\/0006-2952(74)90597-8","article-title":"Stimulation of drug metabolism by ascorbic acid in weanling guinea-pigs","volume":"23","author":"Sato","year":"1974","journal-title":"Biochem. Pharmacol"},{"key":"10.1093\/jn\/116.11.2278_bib20","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0022-3565(25)30596-3","article-title":"Ascorbic acid and hepatic drug metabolism","volume":"198","author":"Sato","year":"1976","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1093\/jn\/116.11.2278_bib21","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/0003-9861(77)90155-2","article-title":"The effects of ascorbic acid deficiency and repletion on pulmonary, renal, and hepatic drug metabolism in guinea pigs","volume":"179","author":"Skic","year":"1977","journal-title":"Arch. Biochem. Biophys"},{"key":"10.1093\/jn\/116.11.2278_bib22","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/S0022-3565(25)31188-2","article-title":"Ascorbic acid and cytochrome P-450","volume":"204","author":"Rikans","year":"1978","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"10.1093\/jn\/116.11.2278_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1079\/BJN19830007","article-title":"Effect of pharmacological doses of ascorbic acid on the hepatic microsomal haemoproteins in the guinea-pig","volume":"49","author":"Sutton","year":"1983","journal-title":"Br. J. Nutr"},{"key":"10.1093\/jn\/116.11.2278_bib24","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/jn\/114.3.485","article-title":"Parabolic response of hepatic microsomal hydroxylating system and lipids to graded doses of ascorbic acid in guinea pigs on low and high \u03b1-tocopherol intake","volume":"114","author":"Ginter","year":"1984","journal-title":"J. Nutr"},{"key":"10.1093\/jn\/116.11.2278_bib25","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1515\/bchm2.1972.353.2.1420","article-title":"Einfluss von \u03b4-aminol-\u00e4vulins\u00e4ure auf den gehalt an cytochrome P-450 in der leber ascorbins\u00e4urefrei emahrter meerschweinchen","volume":"353","author":"Luft","year":"1972","journal-title":"Hoppe-Seyler\u2019s Z. Physiol. Chem"},{"key":"10.1093\/jn\/116.11.2278_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1749-6632.1975.tb29280.x","article-title":"Ascorbic acid and cytochrome","volume":"258","author":"Degkwitz","year":"1975","journal-title":"Ann. NY Acad. Sci"},{"key":"10.1093\/jn\/116.11.2278_bib27","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0006-2952(77)90229-5","article-title":"Ascorbic acid and heme synthesis in deficient guinea pig liver","volume":"26","author":"Rikans","year":"1977","journal-title":"Biochem. Pharmacol"},{"key":"10.1093\/jn\/116.11.2278_bib28","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/0006-2952(80)90282-8","article-title":"Synthesis of cytochrome P-450 heme in ascorbic aciddeficient guinea pigs","volume":"29","author":"Turnbull","year":"1980","journal-title":"Biochem. Pharmacol"},{"key":"10.1093\/jn\/116.11.2278_bib29","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/0006-2952(79)90445-3","article-title":"Heme oxygenase activity, drug metabolism, and ascorbic acid distribution in the livers of ascorbic aciddeficient guinea pigs","volume":"28","author":"Omaye","year":"1979","journal-title":"Biochem. Pharmacol"},{"key":"10.1093\/jn\/116.11.2278_bib30","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1016\/0006-2952(79)90412-X","article-title":"Degradation of cytochrome P-450 heme in ascorbic acid-deficient guinea pigs","volume":"28","author":"Omaye","year":"1979","journal-title":"Biochem. Pharmacol"},{"key":"10.1093\/jn\/116.11.2278_bib31","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1749-6632.1975.tb29273.x","article-title":"Ascorbic acid requirements and metabolism in relation to organochlorine pesticides","volume":"258","author":"Street","year":"1975","journal-title":"Ann. NY Acad. Sci"},{"key":"10.1093\/jn\/116.11.2278_bib32","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/0041-008X(71)90184-0","article-title":"Ascorbic acid deficiency and induction of hepatic microsomal hydroxylative enzymes by organochlorine pesticides","volume":"19","author":"Wagstaff","year":"1971","journal-title":"Toxicol. Appl. Pharmacol"},{"key":"10.1093\/jn\/116.11.2278_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0006-2952(83)90658-5","article-title":"Dietary ascorbic acid and hepatic mixed function oxidase activity in the guinea pig","volume":"32","author":"Peterson","year":"1983","journal-title":"Biochem. Pharmacol"},{"key":"10.1093\/jn\/116.11.2278_bib34","unstructured":"Basu, T. K. (1981) The influence of drugs with particular reference to aspirin on the bioavailability of vitamin C. (Counsell, J. N. & Homig, D. H., eds.) pp. 273-281, Applied Science Publishers Ltd., London."},{"key":"10.1093\/jn\/116.11.2278_bib35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/ajcn\/26.2.191","article-title":"Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature woman","volume":"26","author":"McLeroy","year":"1973","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/116.11.2278_bib36","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/ajcn\/35.6.1408","article-title":"Effect of oral contraceptive agents on ascorbic acid metabolism in the rhesus monkey","volume":"35","author":"Weininger","year":"1982","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/116.11.2278_bib37","first-page":"895","article-title":"Oral contraceptives, norethindrone and mestranol: effect on oxidation, excretion and tissue distribution of L-[U-14C]ascorbic acid in guinea pigs","volume":"31","author":"Young","year":"1985","journal-title":"Nutr. Rep. Int"},{"key":"10.1093\/jn\/116.11.2278_bib38","first-page":"156","article-title":"Vitamin C and cigarette smokers","volume":"258","author":"Pelletier","year":"1975","journal-title":"Ann. NY Acad. Sci"},{"key":"10.1093\/jn\/116.11.2278_bib39","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1093\/ajcn\/34.7.1347","article-title":"On the requirements of ascorbic acid in man: steady-state turnover and body pool in smokers","volume":"34","author":"Kallner","year":"1981","journal-title":"Am. J. Clin. Nutr"},{"key":"10.1093\/jn\/116.11.2278_bib40","first-page":"254","article-title":"Studies on the protective effects of L-ascorbic acid in chronic chlordane toxicity","volume":"51","author":"Chatterjee","year":"1981","journal-title":"Int. J. Vitam. Nutr. Res"},{"key":"10.1093\/jn\/116.11.2278_bib41","first-page":"448","article-title":"Effects of high dose application of lindane to rats and influence of L-ascorbic acid supplementation","volume":"52","author":"Tiwari","year":"1982","journal-title":"Int. J. Vitam. Nutr. Res"},{"key":"10.1093\/jn\/116.11.2278_bib42","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1093\/jn\/111.10.1727","article-title":"Effect of dietary level of ascorbic acid on the growth, hepatic lipid peroxidation, and serum lipids in guinea pigs fed polychlorinated byphenyls","volume":"111","author":"Kato","year":"1981","journal-title":"J. Nutr"}],"container-title":["The Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623079981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022316623079981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/academic.oup.com\/jn\/article-pdf\/116\/11\/2278\/23996348\/jn1160112278.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T13:39:41Z","timestamp":1751204381000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022316623079981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,11]]},"references-count":42,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1986,11]]}},"alternative-id":["S0022316623079981"],"URL":"https:\/\/doi.org\/10.1093\/jn\/116.11.2278","relation":{},"ISSN":["0022-3166"],"issn-type":[{"type":"print","value":"0022-3166"}],"subject":[],"published":{"date-parts":[[1986,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ascorbic Acid Requirement for the Induction of Microsomal Drug-Metabolizing Enzymes in a Rat Mutant Unable to Synthesize Ascorbic Acid","name":"articletitle","label":"Article Title"},{"value":"The Journal of Nutrition","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1093\/jn\/116.11.2278","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 1986 American Society for Nutrition. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}